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home:symptoms:neurological:fatigue [05.02.2011] – external edit 127.0.0.1home:symptoms:neurological:fatigue [01.06.2019] – [Fatigue] sallieq
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 ====== Fatigue ====== ====== Fatigue ======
 +
 +//related article// [[home:diseases:cfs|Chronic fatigue syndrome]]
 +
 +====== Introduction ======
 +
  
 Fatigue is very common in all Th1 diseases and is unrelated to [[home:symptoms:neurological:sleep|sleep]] or rest. The symptom is believe to be caused by inflammatory cytokines, the release of which is a necessary part of immunopathology. Fatigue has been shown to resolve with the Marshall Protocol but can often take quite a while. Fatigue is very common in all Th1 diseases and is unrelated to [[home:symptoms:neurological:sleep|sleep]] or rest. The symptom is believe to be caused by inflammatory cytokines, the release of which is a necessary part of immunopathology. Fatigue has been shown to resolve with the Marshall Protocol but can often take quite a while.
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-===== Pathology of fatigue =====+===== Inflammation causes fatigue =====
  
-Most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D.+The hallmark of chronic diseases is inflammation, the body's response to infection. Inflammation plays an increasingly well-defined role in fatigue.(({{pubmed>long:18793712}}))
  
-One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pubmed>long:16361589}})) +For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pubmed>long:16361589}})) 
  
  
 <blockquote>Once on the MP, some patients report intense exacerbation of symptoms, severe lightheadedness, or profound fatigue, and are convinced that they are getting sicker. I have to assure them that what they are feeling is the natural result of their immune systems dealing with toxins, cellular debris and the remains of dead bacteria. Europeans are usually more open to the idea, but North Americans have really been brainwashed to equate symptoms with disease. In cases where people have trouble grasping this concept, the biggest hurdle is to get them through the first phase of the treatment when the immunopathology is often strongest.  <blockquote>Once on the MP, some patients report intense exacerbation of symptoms, severe lightheadedness, or profound fatigue, and are convinced that they are getting sicker. I have to assure them that what they are feeling is the natural result of their immune systems dealing with toxins, cellular debris and the remains of dead bacteria. Europeans are usually more open to the idea, but North Americans have really been brainwashed to equate symptoms with disease. In cases where people have trouble grasping this concept, the biggest hurdle is to get them through the first phase of the treatment when the immunopathology is often strongest. 
  
-~Greg Blaney, MD</blockquote>+//**Greg Blaney, MD**//</blockquote> 
 + 
 + 
 +==== Virtues of fatigue ===== 
 + 
 +From an evolutionary perspectives, the fatigue caused by inflammation may benefit a person. Andrew Miller of Emory University School of Medicine states in [[http://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect.html|New Scientist]] that "cytokines are trying to shut your body down so that you can devote your resources to healing." In a 2009 paper, he goes on to conclude that fatigue is part of healing: 
 + 
 +<blockquote>Taken together, these effects of cytokines on the brain and behavior appear to subserve competing evolutionary survival priorities that promote reduced activity to allow healing, and hypervigilance to protect against future attack. 
 + 
 +//**Andrew Miller**// 
 +</blockquote> 
 + 
 + 
 ===== Management of fatigue ===== ===== Management of fatigue =====
  
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 //~ToniD//</blockquote> //~ToniD//</blockquote>
  
-{{tag>symptoms}}+{{tag>managing symptoms}}
  
 ===== Notes and comments ===== ===== Notes and comments =====
-EDIT+
  
   *Legacy content   *Legacy content
home/symptoms/neurological/fatigue.txt · Last modified: 09.14.2022 by 127.0.0.1
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