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home:symptoms:neurological [09.01.2019] – [Mental and neurological conditions] sallieqhome:symptoms:neurological [09.14.2022] (current) – external edit 127.0.0.1
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 Looking out for friends and loved ones is an important part of preventing suicide. You can call to speak with a crisis worker on behalf of someone you are concerned about. The crisis workers have access to local resources, and can help you identify ways to get help to your loved ones.  Looking out for friends and loved ones is an important part of preventing suicide. You can call to speak with a crisis worker on behalf of someone you are concerned about. The crisis workers have access to local resources, and can help you identify ways to get help to your loved ones. 
  
-To find out more about the difference you can make in a friend or loved one's life, visit [[http://www.suicidepreventionlifeline.org/GetHelp/WhatIfSomeoneIKnowNeedsHelp.aspx|What If Someone I Know Needs Help]].</note> +To find out more about the difference you can make in a friend or loved one's life, visit [[https://www.suicidepreventionlifeline.org/GetHelp/WhatIfSomeoneIKnowNeedsHelp.aspx|What If Someone I Know Needs Help]].</note> 
  
 ====== Mental and neurological conditions ====== ====== Mental and neurological conditions ======
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 ==== Olmesartan and the brain ==== ==== Olmesartan and the brain ====
  
-At least one early study has suggested that olmesartan is neuroprotective. A 2002 //in vitro// study by Iwasaki //et al.// found that olmesartan improved regrowth of neurons in cultures of ventral spinal cord. On this basis, the team concluded that olmesartan has promise in treating diseases that involve degeneration and death of motor neurons, such as motor neuropathy and amyotrophic lateral sclerosis.(({{pubmed>long:12117316}}))  +At least one early study has suggested that olmesartan is neuroprotective. A 2002 //in vitro// study by Iwasaki //et al.// found that olmesartan improved regrowth of neurons in cultures of ventral spinal cord. On this basis, the team concluded that olmesartan has promise in treating diseases that involve degeneration and death of motor neurons, such as motor neuropathy and amyotrophic lateral sclerosis.(({{pmid>long:12117316}}))  
  
 ===== Blood-brain barrier is leaky ===== ===== Blood-brain barrier is leaky =====
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 The existence of a blood-brain barrier has been historically touted as a reason why microbes could not possibly have caused any number of neurological diseases. However, with the accumulation of additional evidence, this concept has progressively lost meaning.  The existence of a blood-brain barrier has been historically touted as a reason why microbes could not possibly have caused any number of neurological diseases. However, with the accumulation of additional evidence, this concept has progressively lost meaning. 
  
-  * **cytokines traverse the blood-brain barrier** – Until recently, it was commonly assumed that cytokines, signaling molecules released by the immune system in response to infection, are too large to pass freely through the blood-brain barrier. However, recent studies have shown that they can enter through naturally occurring leaky regions and via specialized channels. They can also affect nerves that transmit signals into the brain. There is growing evidence that cytokines associated with inflammation can cause depression. For instance, if you inject a healthy person with interferon-alpha, an antiviral drug that prompts the release of inflammatory cytokines, they will begin to show symptoms of depression.(({{pubmed>long:18793712}})) +  * **cytokines traverse the blood-brain barrier** – Until recently, it was commonly assumed that cytokines, signaling molecules released by the immune system in response to infection, are too large to pass freely through the blood-brain barrier. However, recent studies have shown that they can enter through naturally occurring leaky regions and via specialized channels. They can also affect nerves that transmit signals into the brain. There is growing evidence that cytokines associated with inflammation can cause depression. For instance, if you inject a healthy person with interferon-alpha, an antiviral drug that prompts the release of inflammatory cytokines, they will begin to show symptoms of depression.(({{pmid>long:18793712}})) 
-  * **microbes traverse the blood-brain barrier** – According to a //Nature Reviews Microbiology// paper, microbes can cross the blood-brain barrier transcellularly, paracellularly and/or in infected phagocytes – the so-called Trojan-horse mechanism.(({{pubmed>long:18604221}}))+  * **microbes traverse the blood-brain barrier** – According to a //Nature Reviews Microbiology// paper, microbes can cross the blood-brain barrier transcellularly, paracellularly and/or in infected phagocytes – the so-called Trojan-horse mechanism.(({{pmid>long:18604221}}))
  
 <blockquote>A range of bacteria and bacterial toxins... establish intimate interactions with endothelial cells [cells that comprise the membrane], triggering inflammatory responses and coagulation processes and modifying endothelial cell plasma membranes and junctions to adhere to their surfaces and then invade, cross and even disrupt the endothelial barrier. <blockquote>A range of bacteria and bacterial toxins... establish intimate interactions with endothelial cells [cells that comprise the membrane], triggering inflammatory responses and coagulation processes and modifying endothelial cell plasma membranes and junctions to adhere to their surfaces and then invade, cross and even disrupt the endothelial barrier.
  
-//**E. Lemichez** et al., Breaking the wall: targeting of the endothelium by pathogenic bacteria// (({{pubmed>long:20040916}}))</blockquote>+//**E. Lemichez** et al., Breaking the wall: targeting of the endothelium by pathogenic bacteria// (({{pmid>long:20040916}}))</blockquote>
  
-One prominent example of a microbe that passes the blood-brain barrier is //Borrelia//.(({{pubmed>long: 15664945}}))+One prominent example of a microbe that passes the blood-brain barrier is //Borrelia//.(({{pmid>long: 15664945}}))
  
  
-The brain immune system, which consists mainly of astrocytes, microglia and infiltrating immune cells, is quiescent normally, but it is activated in response to pathophysiological events such as ischemia, trauma, inflammation and infection.  (({{pubmed>long:    16125796}}))+The brain immune system, which consists mainly of astrocytes, microglia and infiltrating immune cells, is quiescent normally, but it is activated in response to pathophysiological events such as ischemia, trauma, inflammation and infection.  (({{pmid>long:    16125796}}))
  
- Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading to blood brain barrier (BBB) dysfunction.  (({{pubmed>long:    30837844}}))  + Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading to blood brain barrier (BBB) dysfunction.  (({{pmid>long:    30837844}}))  
  
  
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 <blockquote>One of the striking features of a variety of neuropsychiatric diseases (e.g., affective disorders) is their variance, with differences observed across individuals in terms of their susceptibility, in the combination of systems that are disturbed, and in the therapeutic and adverse responses to various medications. [We put forth] the possibility that the microbiome represents a source of this observed variance. <blockquote>One of the striking features of a variety of neuropsychiatric diseases (e.g., affective disorders) is their variance, with differences observed across individuals in terms of their susceptibility, in the combination of systems that are disturbed, and in the therapeutic and adverse responses to various medications. [We put forth] the possibility that the microbiome represents a source of this observed variance.
  
-//**A. Gonzalez**, The mind-body-microbial continuum//(({{pubmed>long:21485746}}))+//**A. Gonzalez**, The mind-body-microbial continuum//(({{pmid>long:21485746}}))
 </blockquote> </blockquote>
  
  
 The following offers the evidence to support such statements:  The following offers the evidence to support such statements: 
-  * **[[home:diseases:alzheimers_dementia|Alzheimer's disease and dementia]]** – Alzheimer's caregivers are more likely to get sick,((Norton MC, Smith KR, Øÿstbye T, Tschanz JT, Corcoran C, Schwartz S, et al. [[http://www3.interscience.wiley.com/journal/123421692/abstract?CRETRY=1&SRETRY=0|Greater Risk of Dementia When Spouse Has Dementia? The Cache County Study]]. //Journal of the American Geriatrics Society//. 2010;58(5):895-900.)) and "peripheral" infections can hasten the onset and progression of the condition.(({{pubmed>long:12754353}})) Perhaps the most striking of this evidence is that amyloid-beta, the protein which builds up in the brains of Alzheimer's patients, is an antimicrobial petide.  +  * **[[home:diseases:alzheimers_dementia|Alzheimer's disease and dementia]]** – Alzheimer's caregivers are more likely to get sick,((Norton MC, Smith KR, Øÿstbye T, Tschanz JT, Corcoran C, Schwartz S, et al. [[https://www3.interscience.wiley.com/journal/123421692/abstract?CRETRY=1&SRETRY=0|Greater Risk of Dementia When Spouse Has Dementia? The Cache County Study]]. //Journal of the American Geriatrics Society//. 2010;58(5):895-900.)) and "peripheral" infections can hasten the onset and progression of the condition.(({{pmid>long:12754353}})) Perhaps the most striking of this evidence is that amyloid-beta, the protein which builds up in the brains of Alzheimer's patients, is an antimicrobial petide.  
-  * **[[home:diseases:anxiety|anxiety]]** – Lab mice dosed with //Campylobacter jejuni//, bacteria that are commonly a cause of food poisoning, are more anxious than control mice. One team concluded that the vagus nerve, which extends into the colon, was probably transmitting the news of a gut infection to the brain areas involved in emotions. Further, anxiety often exhibited by victims of bowel disorders may operate on the same network, which is not under conscious control.(({{pubmed>long:17428636}})) Another team also concluded that germ-free mice exhibit reduced anxiety.(({{pubmed>long:21054680}})) +  * **[[home:diseases:anxiety|anxiety]]** – Lab mice dosed with //Campylobacter jejuni//, bacteria that are commonly a cause of food poisoning, are more anxious than control mice. One team concluded that the vagus nerve, which extends into the colon, was probably transmitting the news of a gut infection to the brain areas involved in emotions. Further, anxiety often exhibited by victims of bowel disorders may operate on the same network, which is not under conscious control.(({{pmid>long:17428636}})) Another team also concluded that germ-free mice exhibit reduced anxiety.(({{pmid>long:21054680}})) 
-  * **[[home:diseases:autism|autism spectrum disorder]]** – Growing evidence exists to conclude that autism spectrum disorder is driven by microbial pathogens. Patients with autism tend to suffer from severe gastrointestinal problems and have different bacteria in their GI tract. Children with ASD exhibit fewer characteristic autistic behaviors during fever, a change which was unrelated to fever severity.(({{pubmed>long:18055656}})) This provocative change in behavior may be due to the fact that acute infections such as those which cause fevers may temporarily delay immunopathology. In the absence of immunopathology, autistic children display less behaviors characteristic of autism and consistent with die-off of chronic bacteria. +  * **[[home:diseases:autism|autism spectrum disorder]]** – Growing evidence exists to conclude that autism spectrum disorder is driven by microbial pathogens. Patients with autism tend to suffer from severe gastrointestinal problems and have different bacteria in their GI tract. Children with ASD exhibit fewer characteristic autistic behaviors during fever, a change which was unrelated to fever severity.(({{pmid>long:18055656}})) This provocative change in behavior may be due to the fact that acute infections such as those which cause fevers may temporarily delay immunopathology. In the absence of immunopathology, autistic children display less behaviors characteristic of autism and consistent with die-off of chronic bacteria. 
-  * **[[home:symptoms:neurological:cognitive|cognitive dysfunction (brain fog)]]** – The decline in brain function associated with disease and old age could be due to the decline in the function of immune cells, which is likely caused by (sub-clinical) infection. Whether certain animal studies(({{pubmed>long:15141078}})) (({{pubmed>long:20439540}})) illustrating this are relevant to human learning and memory remains unclear, but there is some indirect evidence to support it. For example, many chemotherapy drugs suppress the immune system, which might explain why some people with cancer develop "chemobrain." Also, cognitive and functional decline often follow severe sepsis. Following severe sepsis hospitalization, but not nonsepsis general hospitalization, there was a significant increase in the odds of developing both cognitive and physical dysfunction that persisted throughout the 8-year follow-up period.(({{pubmed>long:20978262}})) +  * **[[home:symptoms:neurological:cognitive|cognitive dysfunction (brain fog)]]** – The decline in brain function associated with disease and old age could be due to the decline in the function of immune cells, which is likely caused by (sub-clinical) infection. Whether certain animal studies(({{pmid>long:15141078}})) (({{pmid>long:20439540}})) illustrating this are relevant to human learning and memory remains unclear, but there is some indirect evidence to support it. For example, many chemotherapy drugs suppress the immune system, which might explain why some people with cancer develop "chemobrain." Also, cognitive and functional decline often follow severe sepsis. Following severe sepsis hospitalization, but not nonsepsis general hospitalization, there was a significant increase in the odds of developing both cognitive and physical dysfunction that persisted throughout the 8-year follow-up period.(({{pmid>long:20978262}})) 
-  * **intelligence** – Venkataramani [[http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1679164|studied]] the effect of malaria on IQ in a sample of Mexicans. Exposure during the birth year to malaria eradication was associated with increases in IQ. The author suggests that this may be one explanation for the substantial increase in average scores on intelligence tests all over the world (known as the Flynn effect) and that this may be an important explanation for the link between national malaria burden and economic development. In this vein, Eppig //et al.// performed a broad analysis of the relationship between average intelligence and parasite load. Using three measures of average national intelligence quotient (IQ), the team found a robust worldwide (as well as within five of six world regions) inverse correlation between intelligence and infectious burden. According to their analysis, infectious disease remains the most powerful predictor of average national IQ when temperature, distance from Africa, gross domestic product per capita and several measures of education are controlled for. The team theorizes, "From an energetics standpoint, a developing human will have difficulty building a brain and fighting off infectious diseases at the same time, as both are very metabolically costly tasks" and that "the Flynn effect may be caused in part by the decrease in the intensity of infectious diseases as nations develop."(({{pubmed>long:20591860}})) +  * **intelligence** – Venkataramani [[https://papers.ssrn.com/sol3/papers.cfm?abstract_id=1679164|studied]] the effect of malaria on IQ in a sample of Mexicans. Exposure during the birth year to malaria eradication was associated with increases in IQ. The author suggests that this may be one explanation for the substantial increase in average scores on intelligence tests all over the world (known as the Flynn effect) and that this may be an important explanation for the link between national malaria burden and economic development. In this vein, Eppig //et al.// performed a broad analysis of the relationship between average intelligence and parasite load. Using three measures of average national intelligence quotient (IQ), the team found a robust worldwide (as well as within five of six world regions) inverse correlation between intelligence and infectious burden. According to their analysis, infectious disease remains the most powerful predictor of average national IQ when temperature, distance from Africa, gross domestic product per capita and several measures of education are controlled for. The team theorizes, "From an energetics standpoint, a developing human will have difficulty building a brain and fighting off infectious diseases at the same time, as both are very metabolically costly tasks" and that "the Flynn effect may be caused in part by the decrease in the intensity of infectious diseases as nations develop."(({{pmid>long:20591860}})) 
-  *  **obsessive-compulsive disorder (OCD) and pediatric autoimmune neuropsychiatric disorders (PANDAS)** – Both PANDAS and OCD are associated with streptococcal infections.(({{pubmed>long:15820236}})) (({{pubmed>long:21486169}})) +  *  **obsessive-compulsive disorder (OCD) and pediatric autoimmune neuropsychiatric disorders (PANDAS)** – Both PANDAS and OCD are associated with streptococcal infections.(({{pmid>long:15820236}})) (({{pmid>long:21486169}})) 
-  * **[[home:diseases:schizophrenia|schizophrenia]]** – According to Alan S. Brown of Columbia University, "Accumulating evidence suggests that prenatal exposure to infection contributes to the etiology of schizophrenia." In a 2006 study, Brown showed that prenatal infections such as rubella, influenza, and toxoplasmosis are all associated with higher incidence of schizophrenia.(({{pubmed>long:16469941}})) Brown found a seven-fold increased risk of schizophrenia when mothers were exposed to influenza in the first trimester of gestation. This work was echoed by a 2009 paper by Sørensen //et al.// who showed that bacterial infections (upper respiratory tract and gonococcal infections) were associated with elevated risk of the disease.(({{pubmed>long:18832344}}))+  * **[[home:diseases:schizophrenia|schizophrenia]]** – According to Alan S. Brown of Columbia University, "Accumulating evidence suggests that prenatal exposure to infection contributes to the etiology of schizophrenia." In a 2006 study, Brown showed that prenatal infections such as rubella, influenza, and toxoplasmosis are all associated with higher incidence of schizophrenia.(({{pmid>long:16469941}})) Brown found a seven-fold increased risk of schizophrenia when mothers were exposed to influenza in the first trimester of gestation. This work was echoed by a 2009 paper by Sørensen //et al.// who showed that bacterial infections (upper respiratory tract and gonococcal infections) were associated with elevated risk of the disease.(({{pmid>long:18832344}}))
  
  
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 Other evidence includes: Other evidence includes:
  
-  * **patients injected with bacterial endotoxin show mental disturbances** – In a double-blind, crossover study, 20 healthy male volunteers completed psychological questionnaires and neuropsychological tests 1, 3, and 9 hours after intravenous injection of //Salmonella abortus equi// endotoxin (0.8 ng/kg) or saline in 2 experimental sessions. While the endotoxin group did not experience physical sickness symptoms including change in blood pressure or heart rate, there was a significant increase in anxiety, depressed mood, and decreases in memory performance.(({{pubmed>long:11343523}}))+  * **patients injected with bacterial endotoxin show mental disturbances** – In a double-blind, crossover study, 20 healthy male volunteers completed psychological questionnaires and neuropsychological tests 1, 3, and 9 hours after intravenous injection of //Salmonella abortus equi// endotoxin (0.8 ng/kg) or saline in 2 experimental sessions. While the endotoxin group did not experience physical sickness symptoms including change in blood pressure or heart rate, there was a significant increase in anxiety, depressed mood, and decreases in memory performance.(({{pmid>long:11343523}}))
  
 ==== Gut-brain axis ==== ==== Gut-brain axis ====
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 <blockquote>Infection and inflammation lead to changes in mood and cognition. Although the "classic" sickness behavior syndrome, involving fatigue, social withdrawal, and loss of appetites are most familiar, other emotional responses accompany immune activation, including anxiety. Recent studies have shown that gastrointestinal bacterial infections lead to enhanced anxiety-like behavior in mice. The bacteria-induced signal is most likely carried by vagal sensory neurons, and occurs early on (within 6h) during the infection. These signals induce evidence of activation in brain regions that integrate viscerosensory information with mood, and potentiate activation in brain regions established as key players in fear and anxiety.  <blockquote>Infection and inflammation lead to changes in mood and cognition. Although the "classic" sickness behavior syndrome, involving fatigue, social withdrawal, and loss of appetites are most familiar, other emotional responses accompany immune activation, including anxiety. Recent studies have shown that gastrointestinal bacterial infections lead to enhanced anxiety-like behavior in mice. The bacteria-induced signal is most likely carried by vagal sensory neurons, and occurs early on (within 6h) during the infection. These signals induce evidence of activation in brain regions that integrate viscerosensory information with mood, and potentiate activation in brain regions established as key players in fear and anxiety. 
  
-//**L.E. Goehler** et al.//(({{pubmed>long:17428636}}))</blockquote>+//**L.E. Goehler** et al.//(({{pmid>long:17428636}}))</blockquote>
  
-The 100 trillion bacteria which together make up the intestinal microbiome are engaged in all the complex interactions with each other and the local tissue and in a balanced manner maintain normal homeostasis. They synthesize a vast array of biologically and neuroactive molecules including an almost complete array of neurotransmitters such as GABA, and through fermentation, a panoply of short chain fatty acids all of which have known and unknown effects on the nervous system. The direct and indirect effects of the intestinal microbiome on the intestinal epithelium, the local mucosal immune system and their cytokines, as well as the enteric nervous system, conspire to affect the afferent neuronal pathways to the brain. In turn, through complex interactional effects upon the HPA axis and especially central nervous system target structures affected by tractus solitarius activation in the brain stem, increasing evidence is pointing towards an influence by the intestinal microbiota upon cognition and mood.(({{pubmed>long:19481599}}))+The 100 trillion bacteria which together make up the intestinal microbiome are engaged in all the complex interactions with each other and the local tissue and in a balanced manner maintain normal homeostasis. They synthesize a vast array of biologically and neuroactive molecules including an almost complete array of neurotransmitters such as GABA, and through fermentation, a panoply of short chain fatty acids all of which have known and unknown effects on the nervous system. The direct and indirect effects of the intestinal microbiome on the intestinal epithelium, the local mucosal immune system and their cytokines, as well as the enteric nervous system, conspire to affect the afferent neuronal pathways to the brain. In turn, through complex interactional effects upon the HPA axis and especially central nervous system target structures affected by tractus solitarius activation in the brain stem, increasing evidence is pointing towards an influence by the intestinal microbiota upon cognition and mood.(({{pmid>long:19481599}}))
  
-Collectively, the human gut microbiome contributes 36% of the small molecules that are found in human blood.(({{pubmed>long:22674329}}))+Collectively, the human gut microbiome contributes 36% of the small molecules that are found in human blood.(({{pmid>long:22674329}}))
  
-The surprisingly high compositional variation in gut bacteria across individuals stands in stark contrast to the small amount of genetic diversity uncovered in the sequencing of our human genomes.(({{pubmed>long:21485746}})) Differences in our microbial communities may thus be one of the most important factors in differences in the metabolites that individuals extract from similar diets.+The surprisingly high compositional variation in gut bacteria across individuals stands in stark contrast to the small amount of genetic diversity uncovered in the sequencing of our human genomes.(({{pmid>long:21485746}})) Differences in our microbial communities may thus be one of the most important factors in differences in the metabolites that individuals extract from similar diets.
  
-2018 electron microscope study [[http://nautil.us/issue/66/clockwork/are-there-bacteria-in-your-brain|bacteria-in-your-brain]]+2018 electron microscope study [[https://nautil.us/issue/66/clockwork/are-there-bacteria-in-your-brain|bacteria-in-your-brain]]
  
  
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 ===== Read more ===== ===== Read more =====
  
-  * [[http://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect.html|Infectious moods: A depressing side effect]] +  * [[https://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect.html|Infectious moods: A depressing side effect]] 
  
  
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 {{tag>symptoms managing disease}} {{tag>symptoms managing disease}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 <blockquote>Infectious Triggers of Mental Illness <blockquote>Infectious Triggers of Mental Illness
  
-Jill Neimark wrote an article in the 25th Anniversary Issue of Discover Magazine (Frontiers of Science) on infectious triggers of mental illness. It is out on the news stands now and will soon be on the Discover website at http://www.discover.com/+Jill Neimark wrote an article in the 25th Anniversary Issue of Discover Magazine (Frontiers of Science) on infectious triggers of mental illness. It is out on the news stands now and will soon be on the Discover website at https://www.discover.com/
  
-http://msnbc.msn.com/id/3540627/+https://msnbc.msn.com/id/3540627/
  
 Diseases of the Mind Diseases of the Mind
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   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum32/4972.html#p45660 f178  +    * https://www.marshallprotocol.com/forum32/4972.html#p45660 f178  
-    * http://www.marshallprotocol.com/view_topic.php?id=4972&forum_id=32&jump_to=86108#p86108 f180  +    * https://www.marshallprotocol.com/view_topic.php?id=4972&forum_id=32&jump_to=86108#p86108 f180  
-    * http://www.marshallprotocol.com/forum37/4243.html#p37976 s58  +    * https://www.marshallprotocol.com/forum37/4243.html#p37976 s58  
-    * http://www.marshallprotocol.com/forum37/4243.html#p56240 s65  +    * https://www.marshallprotocol.com/forum37/4243.html#p56240 s65  
-    * http://www.marshallprotocol.com/view_topic.php?id=4243&forum_id=37&jump_to=85543#p85543 s69  +    * https://www.marshallprotocol.com/view_topic.php?id=4243&forum_id=37&jump_to=85543#p85543 s69  
-    * http://www.marshallprotocol.com/forum32/3558.html#p31834 f272+    * https://www.marshallprotocol.com/forum32/3558.html#p31834 f272
  
 Neurological symptoms may include: Neurological symptoms may include:
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   * poor problem-solving   * poor problem-solving
   * fear   * fear
-  * [[http://en.wikipedia.org/wiki/Anxiety|anxiety]]+  * [[https://en.wikipedia.org/wiki/Anxiety|anxiety]]
   * depressive disorders   * depressive disorders
-  * [[http://en.wikipedia.org/wiki/Psychosis|psychosis]]+  * [[https://en.wikipedia.org/wiki/Psychosis|psychosis]]
   * insomnia   * insomnia
  
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 <blockquote>I guess the simple reply to the “science” behind these symptoms is that our brains, cranial nerves, spinal cord and nerves emerging from our cord; as well as peripheral nerves(the whole dang system) are infected with CWD organisms. I suspect there are a number of errant feedback loops and “short circuits” in our brains as well as primary nerve involvement. There is a neurologic syndrome caller Barre-Lieou that involves pinched or inflamed nerves in the cervical spine having effects on the rest of the system.  <blockquote>I guess the simple reply to the “science” behind these symptoms is that our brains, cranial nerves, spinal cord and nerves emerging from our cord; as well as peripheral nerves(the whole dang system) are infected with CWD organisms. I suspect there are a number of errant feedback loops and “short circuits” in our brains as well as primary nerve involvement. There is a neurologic syndrome caller Barre-Lieou that involves pinched or inflamed nerves in the cervical spine having effects on the rest of the system. 
  
-http://www.medhelp.org/forums/neuro/archive/325.html +https://www.medhelp.org/forums/neuro/archive/325.html 
  
 Some people have reported improvement with skilled osteopathic manipulation or prolotherapy if it is just a post whiplash type injury effecting the neck; but I feel the root of our problem is CWD infection. An MRI can not show cwd infection and can not cure you, but if expense is affordable it does rule out some possibilities like bulging disk and spinal stenosis (for peace of mind) But I feel the little beasties are most likely the problem.  Some people have reported improvement with skilled osteopathic manipulation or prolotherapy if it is just a post whiplash type injury effecting the neck; but I feel the root of our problem is CWD infection. An MRI can not show cwd infection and can not cure you, but if expense is affordable it does rule out some possibilities like bulging disk and spinal stenosis (for peace of mind) But I feel the little beasties are most likely the problem. 
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 Brain lesions Brain lesions
  
--It seems you are still trying to understand if the lesions indicated on your brain MRI could have been from sarcoidosis. This [[http://bjr.birjournals.org/cgi/reprint/70/836/859.pdf|article]] cited a couple of sources in stating, "MRI findings of CNS [central nervous system] sarcoidosis including white matter, periventricular, periacuaductal or leptomengial lesions, have often been reported."+-It seems you are still trying to understand if the lesions indicated on your brain MRI could have been from sarcoidosis. This [[https://bjr.birjournals.org/cgi/reprint/70/836/859.pdf|article]] cited a couple of sources in stating, "MRI findings of CNS [central nervous system] sarcoidosis including white matter, periventricular, periacuaductal or leptomengial lesions, have often been reported."
  
-Keep in mind that while inflammation is central to numerous diseases, it is also an important part of the body's repair processes.  This [[http://www.ncbi.nlm.nih.gov/pubmed/18651996|report]] says inflammation is pivitol for repair of peripheral nerve damage, for instance. So signs of inflammation can be related to disease as well as to healing and repair.+Keep in mind that while inflammation is central to numerous diseases, it is also an important part of the body's repair processes.  This [[https://www.ncbi.nlm.nih.gov/pubmed/18651996|report]] says inflammation is pivitol for repair of peripheral nerve damage, for instance. So signs of inflammation can be related to disease as well as to healing and repair.
  
-Sarcoidosis can result in brain involvement even in pediatric patients, so you are not too young. This [[http://www.ncbi.nlm.nih.gov/pubmed/18317442|abstract]] says, "Among inflammatory conditions, granulomatous diseases such as sarcoidosis have predilection for involvement of the suprasellar regions and can spread along perivascular spaces deep within the parenchyma."+Sarcoidosis can result in brain involvement even in pediatric patients, so you are not too young. This [[https://www.ncbi.nlm.nih.gov/pubmed/18317442|abstract]] says, "Among inflammatory conditions, granulomatous diseases such as sarcoidosis have predilection for involvement of the suprasellar regions and can spread along perivascular spaces deep within the parenchyma."
  
  
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 </blockquote> </blockquote>
  
-<blockquote>http://www.sciencedaily.com/releases/2011/05/110517110315.htm+<blockquote>https://www.sciencedaily.com/releases/2011/05/110517110315.htm
  
 Gut Bacteria Linked to Behavior: That Anxiety May Be in Your Gut, Not in Your Head Gut Bacteria Linked to Behavior: That Anxiety May Be in Your Gut, Not in Your Head
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 <blockquote>Early Gut Bacteria Regulate HappinessInbox <blockquote>Early Gut Bacteria Regulate HappinessInbox
  
-http://www.sciencedaily.com/releases/2012/06/120612115812.htm+https://www.sciencedaily.com/releases/2012/06/120612115812.htm
  
  
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 Linda Geddes https://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect/ Linda Geddes https://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect/
  
-===== References =====+===== References =====</nodisp> 
home/symptoms/neurological.txt · Last modified: 09.14.2022 by 127.0.0.1
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