Differences

This shows you the differences between two versions of the page.

--- home:symptoms:skin [11.15.2011] – paulalbert
+++ home:symptoms:skin [08.30.2012] – [Skin microbiome] paulalbert
@@ Line 12: / Line 12: @@
+===== Skin microbiome =====
+A decade ago, Chiller //et al.// concluded, “The skin is a poor media for bacteria given the large number of inherent defense mechanisms.”(({{pubmed>long:11924823}})) This assessment was undermined seven years later by Fierer //et al//.’s work, which found that the average human palm harbors at least 150 bacterial species – an order of magnitude greater than previous estimates.(({{pubmed>long:19004758}})) A 2009 //Science// study expanded on this understanding of microbial diversity in skin, showing that forearms and underarms, though located just a short distance apart, are as “ecologically dissimilar as rainforests are to deserts.”(({{pubmed>long:19478181}})) Trillions of bacteria, fungi, viruses, archaea, and small arthropods colonize the skin surface, collectively comprising the skin microbiome.(({{pubmed>long:22189793}})) One prominent researcher [[http://news.bbc.co.uk/1/hi/health/6333137.stm|called]] human skin a "virtual zoo of bacteria."(({{pubmed>long:17293459}}))
+Novel insights are being revealed about the extent to which skin microbiota affects health. For example, odors produced by skin microbiota are attractive to mosquitoes as shown by //in vitro// studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans.(({{pubmed>long:20840217}}))
@@ Line 27: / Line 33: @@
 Patients experiences
+===== Atopic dermatitis =====
+<blockquote>
+.
+Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin.
+Gambichler T, Skrygan M, Tomi NS, Othlinghaus N, Brockmeyer NH, Altmeyer P, Kreuter A.
+Int Arch Allergy Immunol. 2008;147(1):17-24. Epub 2008 Apr 30.
+PMID: 18446049 [PubMed - indexed for MEDLINE]
+Related citations Remove from clipboard
+The role of antimicrobial peptides in human skin and in skin infectious diseases.
+Schittek B, Paulmann M, Senyürek I, Steffen H.
+Infect Disord Drug Targets. 2008 Sep;8(3):135-43. Review.
+PMID: 18782030 [PubMed - indexed for MEDLINE]
+</blockquote>
@@ Line 41: / Line 71: @@
+===== Comorbidities =====
 <blockquote>
@@ Line 78: / Line 107: @@
-{{tag>symptoms incomplete}}
+===== Cutaneous manifestations of immunopathology =====
-===== Notes and comments =====
-REVISE
-  * Legacy content
-s290:
-Cutaneous manifestations of Th1 inflammation
 Cutaneous immunopathology
@@ Line 112: / Line 132: @@
 Cosmetics may help cover a discoloration. Use moisturizers as needed and avoid sunlight and extreme heat. Consult your physician if you continue to have concerns.
-Lupus pernio
+===== Lupus pernio =====
 Lesions on the face that occur or exacerbate when it's cold or windy can be what is called lupus pernio. Lupus Pernio is a skin manifestation of sarcoidosis. Lupus Pernio is not another disease (and is not related to lupus), it's simply a name for the red-to purplish lesions that can appear on the nose, face, ears or hands of sarcoidosis patients. These lesions can occur when the nose, face or hands are exposed to cold or wind, so it's a good idea for sarcies to keep these areas protected from wind and cold. Avoiding exposure to bright lights is also an important preventative measure.
@@ Line 126: / Line 146: @@
 Lupus pernio is said to be the skin lesion most characteristic (a diagnostic indicator) of sarcoidosis, but not all sarcoidosis patients have these skin lesions.
--My experience with lupus pernio is that it flares with exposure to light plus cold and wind. I suspect you have still been having a good bit of cool wind and weather in your part of the world. You may need to keep your nose better protected. I know that's hard to do, so if nothing else, you can stay indoors during daytime as much as possible and wrap a scarf around your nose if it is cool or windy.
+==== Patients experiences ====
+<blockquote>My experience with lupus pernio is that it flares with exposure to light plus cold and wind. I suspect you have still been having a good bit of cool wind and weather in your part of the world. You may need to keep your nose better protected. I know that's hard to do, so if nothing else, you can stay indoors during daytime as much as possible and wrap a scarf around your nose if it is cool or windy.
+Warning of the risk of scarring, whether on the skin or in the lungs, is a common tactic to pressure patients to use the treatment a physician prefers. Lupus pernio has a reputation for being difficult to treat. In reality, the doctor has no way to know whether you will scar. Certainly I sustained no scars from my winter bouts with lupus pernio.
+//**Belinda**, MarshallProtocol.com//</blockquote>
-Warning of the risk of scarring, whether on the skin or in the lungs, is a common tactic to pressure patients to use the treatment a physician prefers. Lupus pernio has a reputation for being difficult to treat. In reality, the doctor has no way to know whether you will scar. Certainly I sustained no scars from my winter bouts with lupus pernio. ~Belinda
 Skin rash
@@ Line 188: / Line 216: @@
 Sarcoid skin lesions can be painful, itchy, oozy or dry and peeling. They can also make your hair fall out. You can find more information and lots of pictures of skin sarcoidosis (to compare with your rashes) in the thread "Skin Sarc, What Does it Look Like?" or Images of cutanenous sarcoidosis.
-Members' experiences
--Ive been on the MP now for 1 year this month. I have skin lesions on my face and i noticed them get better, texture and inflammation wise, when i started the the first meds, olmersartan and then the first antibiotic. Now texture has greatly improved, lesions were very dry, inflamed and flakey and hurt alot when touched before starting MP. A few months ago i noticed, not only have they impoved in texture but some are actually starting to fade on some sides. I've gotten a few new lesions since starting but there also improving. None have actually completely gone or disappeared but i think now there starting to show signs of great improvement ahead and i feel that  from the improvements i have witnessed that they will fade away and leave no marks, some time in the near future. I havent yet reached the the optimal level of all antibiotics yet but hopeful will in November and then stay at that optimal level for the next 12-24 months, so im sure i will see more improvement and disappearance of the lesion. ~sd
+===== Skin lesions =====
-Last edited on Thu Oct 23rd, 2008 02:40 by
+==== Patients experiences ====
+<blockquote>Ive been on the MP now for 1 year this month. I have skin lesions on my face and i noticed them get better, texture and inflammation wise, when i started the the first meds, olmersartan and then the first antibiotic. Now texture has greatly improved, lesions were very dry, inflamed and flakey and hurt alot when touched before starting MP. A few months ago i noticed, not only have they impoved in texture but some are actually starting to fade on some sides. I've gotten a few new lesions since starting but there also improving. None have actually completely gone or disappeared but i think now there starting to show signs of great improvement ahead and i feel that  from the improvements i have witnessed that they will fade away and leave no marks, some time in the near future. I havent yet reached the the optimal level of all antibiotics yet but hopeful will in November and then stay at that optimal level for the next 12-24 months, so im sure i will see more improvement and disappearance of the lesion.
+//**sd**, MarshallProtocol.com//</blockquote>
-    * s290
-f217:
-The lumps under my skin are worse. Will the MP make them go away?
 The lumps under my skin are worse. Will the MP make them go away?
@@ Line 216: / Line 244: @@
 and Why Does the Body Make Granulomas?
-My lymph nodes are growing. Is this normal? has Member experiences also.
---------------------------------------------------------------------------------
-Generated from this source: http://www.marshallprotocol.com/forum32/7631.html
-WARNING:  THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.
-Migration code: F217
-    * f217
-f92:
-  Posted: Thu Jan 24th, 2008 15:50
-Quote
-Reply
-[filelink]
-Improvements in skin conditions
--Another great thing that is happening to me is my granulomatous raised red skin lesions that had covered 80% of by body has literally cleared up. It's flattened out and browned back to nearly my original olive skin colour.
-All this has made me contact the skin and cancer foundation of Australia where I originally went and got my diagnosis of Sarcoid 8 years ago. I spoke to them and told them about all this. It flew over there heads but they are willing to see me because my case was very interesting for them at the time and I think they want to know how all this stuff works because I'm the living proof of the MP working.~Simon Elrahi
-I had many skin lesions come and go in first year of MP, and just two month ago had a large raised lesion (AK) just slough off and disappear. ~ P.B.
-I have had some interesting changes in areas where I had sun damaged skin. Particularly my neckline and the backs of my hands. At first, the MP seemed to exacerbate the redness in these areas, especially my neckline. For the first two years the skin was very red and irritated. But recently, I've started to notice it feeling much softer to the touch. There seems to be a new layer of fat making the skin feel much softer and the irritation has disappeared. I find myself constantly wanting to touch this skin it is so soft...it is an amazing difference.~ Aunt Diana
-    * f92
-f89:
-I've developed a rash/itching/skin problem. What should I do?
+===== Managing skin symptoms =====
 "Skin eruptions" is listed in this article as a common adverse reaction to tetracyclines. People on the Marshall Protocol have reported exacerbation of skin lesions or acne, minor skin rashes and severe cutaneous reactions. These can be similar to previous skin rashes or entirely new.
@@ Line 290: / Line 286: @@
 You may get relief from intolerable itching with Cyproheptadine, a prescription antihistamine with a side effect of drowsiness.
+===== Other treatments =====
+==== Steroids ====
 Topical steroids
@@ Line 323: / Line 321: @@
 See also:
-Candidiasis (yeast infection)
-Scroll down for information about other skin problems and suggested remedies.
+===== Over the counter remedies =====
-Last edited on Sun Jul 27th, 2008 00:52 by Meg Mangin R.N.
+==== Itchy skin ====
-____________________
+<blockquote>Benadryl cream helps the bits that aren't raw.  A little hydrocortisone on a few places to make life bearable, but as little as possible.  Zyrtec daily helps the itch, especially at night.
-Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
-    * f89
-f90:
+//**Julia**, MarshallProtocol.com//</blockquote>
-Other skin problems and suggestions for OTC remedies
+<blockquote>The thing that finally calmed my face itch down was washing with soap and water and a cream called Florasone (homeopathic for eczema).
+//**Prugg21**, MarshallProtocol.com//</blockquote>
-Itchy skin
+<blockquote>I have had a skin rash on my hands a couple of times since starting the MP, that was similar to yours by the sound of it.  I found that a low dose of antihistamine helped to reduce the itching.  I also used a natural moisturiser containing oatmeal, apparently oats are quite soothing for skin rashes.  You can put some oats in a small cloth bag (or an old sock/pantyhose) and put it in the bath, or use it under the shower.
-Benadryl cream helps the bits that aren't raw.  A little hydrocortisone on a few places to make life bearable, but as little as possible.  Zyrtec daily helps the itch, especially at night. ~Julia
+//**Mel (shadowfeet)**, MarshallProtocol.com//</blockquote>
-The thing that finally calmed my face itch down was washing with soap and water and a cream called Florasone (homeopathic for eczema). ~Prugg21
+<blockquote>I have been using a honey & blackberry soap (from Walmart: in the dish soap area for sensitive skin) My skin sensitivity has eased some and the skin issues that I was having on the backs of my knees have disappeared... no more itching!
--I have had a skin rash on my hands a couple of times since starting the MP, that was similar to yours by the sound of it.  I found that a low dose of antihistamine helped to reduce the itching.  I also used a natural moisturiser containing oatmeal, apparently oats are quite soothing for skin rashes.  You can put some oats in a small cloth bag (or an old sock/pantyhose) and put it in the bath, or use it under the shower. ~Mel (Shadowfeet)
+//**Gail**, MarshallProtocol.com//</blockquote>
--I have been using a honey & blackberry soap (from Walmart: in the dish soap area for sensitive skin) My skin sensitivity has eased some and the skin issues that I was having on the backs of my knees have disappeared...no more itching!  ~ Gail
-Dry, crusty skin
+==== Dry skin ====
-Sween makes a cream called Atrac-tain which contains urea and lactic acid to gently exfoliate the skin. It works remarkably well to remove crusty tissue and restore smooth skin. Try it on a small area first to make sure you are not sensitive to any of the ingredients. It can usually be purchase at a local pharmacy. ~Meg
+<blockquote>Sween makes a cream called Atrac-tain which contains urea and lactic acid to gently exfoliate the skin. It works remarkably well to remove crusty tissue and restore smooth skin. Try it on a small area first to make sure you are not sensitive to any of the ingredients. It can usually be purchase at a local pharmacy.
-Dry skin
+//**Meg**, MarshallProtocol.com//</blockquote>
-The Body Shop has a dry olive oil mist that comes in a spray mister....I really like it. It's not quite as oily as olive oil. You may want to try it. I got mine online at bodyshop.com . ~ Aunt Diana
+<blockquote>The Body Shop has a dry olive oil mist that comes in a spray mister....I really like it. It's not quite as oily as olive oil. You may want to try it. I got mine online at bodyshop.com .
-The chlorine in tap water can be very drying to the skin. You can purchase, for about $45, a charcoal filter for your shower-head which will filter it out. I think it makes a world of difference, you (and anybody else with dry skin) might want to give this a try. ~ Joy
+//**Joy**, MarshallProtocol.com//</blockquote>
+<blockquote>The chlorine in tap water can be very drying to the skin. You can purchase, for about $45, a charcoal filter for your shower-head which will filter it out. I think it makes a world of difference, you (and anybody else with dry skin) might want to give this a try.
+//**Aunt Diana**, MarshallProtocol.com//</blockquote>
+==== Itchy scalp ====
+<blockquote>
+//****, MarshallProtocol.com//</blockquote>
-Itchy scalp
 I had lots of itching and breaking out (skin sarcs) got worse...all herx sxs. Benadryl cream (slathered entire areas) and 2% Ketoconzole cream (treated spots only) worked great to relieve the itching for me...also used Nizoral shampoo for an itchy scalp with total success. ~DNStog
-Psoriasis
+==== Psoriasis ====
+<blockquote>I've had lots of experience with psoriasis (which looks like sarc lesions, BTW). I've found a cream that helps it feel better. It's a combo of mango and shea butter that I buy at Walmart, made by Tree Hut. It's very soothing.
+//**Reenie**, MarshallProtocol.com//</blockquote>
+==== Raw skin lesions ====
+<blockquote>
+//****, MarshallProtocol.com//</blockquote>
-I've had lots of experience with psoriasis (which looks like sarc lesions, BTW). I've found a cream that helps it feel better. It's a combo of mango and shea butter that I buy at Walmart, made by Tree Hut. It's very soothing.  ~Reenie
-Raw skin lesions
 I've had good results applying Campho-Phenique (for lip Cold Sores) on my raw skin lesions when not able to use Benadryl. This OTC medicine stops the itching and burning fast. ~Donna
@@ Line 395: / Line 413: @@
 Many of the white areas on my skin have disappeared! ~Alayne
-See Vitiligo
 Dark pigment changes
@@ Line 493: / Line 516: @@
+===== Patients experiences =====
+==== Improvements in skin conditions ====
-<blockquote>Title:Chemical ecology of interactions between human skin microbiota and mosquitoes(({{pubmed>long:20840217}}))
+-Another great thing that is happening to me is my granulomatous raised red skin lesions that had covered 80% of by body has literally cleared up. It's flattened out and browned back to nearly my original olive skin colour.
-Authors:
+All this has made me contact the skin and cancer foundation of Australia where I originally went and got my diagnosis of Sarcoid 8 years ago. I spoke to them and told them about all this. It flew over there heads but they are willing to see me because my case was very interesting for them at the time and I think they want to know how all this stuff works because I'm the living proof of the MP working.~Simon Elrahi
-Verhulst, NO; Takken, W; Dicke, M; Schraa, G; Smallegange, RC
-Author Full Names:
+I had many skin lesions come and go in first year of MP, and just two month ago had a large raised lesion (AK) just slough off and disappear. ~ P.B.
-Verhulst, Niels O.; Takken, Willem; Dicke, Marcel; Schraa, Gosse; Smallegange, Renate C.
-Source:
+I have had some interesting changes in areas where I had sun damaged skin. Particularly my neckline and the backs of my hands. At first, the MP seemed to exacerbate the redness in these areas, especially my neckline. For the first two years the skin was very red and irritated. But recently, I've started to notice it feeling much softer to the touch. There seems to be a new layer of fat making the skin feel much softer and the irritation has disappeared. I find myself constantly wanting to touch this skin it is so soft...it is an amazing difference.~ Aunt Diana
-FEMS MICROBIOLOGY ECOLOGY 74 (1): 1-9 OCT 2010
-Language:
-English
-Document Type:
-Review
-Author Keywords:
-skin microbiota; disease vectors; HLA; volatiles; odours; Anopheles gambiae
-KeyWords Plus:
-HUMAN AXILLARY ODOR; COMPLETE GENOME SEQUENCE; HUMAN-BODY ODOR; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; MAJOR HISTOCOMPATIBILITY COMPLEX; AEDES-AEGYPTI; MATING PREFERENCES; STAPHYLOCOCCUS-AUREUS; PATTERN-RECOGNITION; MALARIA MOSQUITOS
-Abstract:
-Microbiota on the human skin plays a major role in body odour production. The human microbial and chemical signature displays a qualitative and quantitative correlation. Genes may influence the chemical signature by shaping the composition of the microbiota. Recent studies on human skin microbiota, using 16S rRNA gene sequencing, found a high inter- and intrapersonal variation in bacterial species on the human skin, which is relatively stable over time. Human body odours mediate the attraction of mosquitoes to their blood hosts. Odours produced by skin microbiota are attractive to mosquitoes as shown by in vitro studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans. Detailed knowledge of the ecology and genetics of human skin microbiota is needed in order to unravel the evolutionary mechanisms that underlie the interactions between mosquitoes and their hosts.
-</blockquote>
-<blockquote>Genome Res. 2008 Jul;18(7):1043-50. Epub 2008 May 23.
+{{tag>symptoms incomplete}}
-A diversity profile of the human skin microbiota.
-Grice EA, Kong HH, Renaud G, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA.
-Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
+===== Notes and comments =====
-Abstract
-The many layers and structures of the skin serve as elaborate hosts to microbes, including a diversity of commensal and pathogenic bacteria that contribute to both human health and disease. To determine the complexity and identity of the microbes inhabiting the skin, we sequenced bacterial 16S small-subunit ribosomal RNA genes isolated from the inner elbow of five healthy human subjects. This analysis revealed 113 operational taxonomic units (OTUs; "phylotypes") at the level of 97% similarity that belong to six bacterial divisions. To survey all depths of the skin, we sampled using three methods: swab, scrape, and punch biopsy. Proteobacteria dominated the skin microbiota at all depths of sampling. Interpersonal variation is approximately equal to intrapersonal variation when considering bacterial community membership and structure. Finally, we report strong similarities in the complexity and identity of mouse and human skin microbiota. This study of healthy human skin microbiota will serve to direct future research addressing the role of skin microbiota in health and disease, and metagenomic projects addressing the complex physiological interactions between the skin and the microbes that inhabit this environment.
-PMID: 18502944
-Many lines of evidence suggest a role for microorganisms even in noninfectious skin diseases, such as atopic dermatitis (AD; eczema), rosacea, psoriasis, and acne (Holland et al. 1977; Thomsen et al. 1980;Till et al. 2000; Paulino et al. 2006).</blockquote>
+===== References =====

home/symptoms/skin.txt · Last modified: 09.14.2022 by 127.0.0.1