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- | < | + | ====== Skin conditions ====== |
- | ====== Skin conditions | + | The Marshall Protocol is a therapy designed to activate the body's innate immune response against persistent infections. The treatment generates a healing response known as immunopathology. Immunopathology can manifest in a variety of ways including a temporary rise in markers of inflammation. For patients with skin disease, this may mean an increase in existing symptoms. |
- | * edema (swelling) | + | Patients whose cutaneous immunopathology is intolerable may wish to ignore it, or treat it palliatively until it resolves, while continuing the MP. Relief of immunopathology symptoms may be obtained by adhering to the standard methods for reducing immunopathology including adjusting olmesartan or antibiotics. At least several MP patients have been treated for the following skin conditions: |
- | * lumps | + | |
- | * pruritus (itchiness) | + | |
- | * rash | + | |
- | * vitilligo | + | |
- | * shingles | + | |
- | * odor | + | |
+ | * **atopic dermatitis** – involves scaly and itchy rashes | ||
+ | * **edema** – swelling | ||
+ | * **erythema nodosum** – involves tender, red bumps (nodules) under the skin | ||
+ | * < | ||
+ | * **moles** | ||
+ | * **psoriasis** – a common skin condition that causes skin redness and irritation. Most people with psoriasis have thick, red skin with flaky, silver-white patches called scales. Discussed at length in the Psoriasis article. | ||
+ | * **pruritus** – rash and itching | ||
+ | * **skin tags (acrochordons)** – common, acquired, benign skin growths that look like a small piece of soft, hanging ski | ||
+ | * **shingles** – a painful, blistering skin rash due to the varicella-zoster virus | ||
+ | * **vitilligo** – loss of brown color (pigment) from areas of skin, resulting in irregular white patches that feel like normal skin | ||
- | ===== Skin microbiome ===== | ||
- | < | + | ===== Skin microbiome ===== |
- | Authors: | + | A decade ago, Chiller //et al.// concluded, “The skin is a poor media for bacteria given the large number of inherent defense mechanisms.”(({{pubmed> |
- | Verhulst, NO; Takken, W; Dicke, M; Schraa, G; Smallegange, RC | + | |
- | Author Full Names: | + | Novel insights are being revealed about the extent to which skin microbiota affects health. For example, odors produced by skin microbiota are attractive to mosquitoes as shown by //in vitro// studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans.(({{pubmed> |
- | Verhulst, Niels O.; Takken, Willem; Dicke, Marcel; Schraa, Gosse; Smallegange, | + | |
- | Source: | ||
- | FEMS MICROBIOLOGY ECOLOGY 74 (1): 1-9 OCT 2010 | ||
- | Language: | + | ===== Immune response and skin disease ===== |
- | English | + | |
- | Document Type: | + | In human skin antimicrobial peptide (AMP) are produced mainly by keratinocytes, |
- | Review | + | |
- | Author Keywords: | ||
- | skin microbiota; disease vectors; HLA; volatiles; odours; Anopheles gambiae | ||
- | KeyWords Plus: | + | ===== Immunopathology in the skin ===== |
- | HUMAN AXILLARY ODOR; COMPLETE GENOME SEQUENCE; HUMAN-BODY ODOR; GAS CHROMATOGRAPHY/ | + | |
- | Abstract: | + | The Marshall Protocol |
- | Microbiota on the human skin plays a major role in body odour production. | + | |
- | </ | + | |
- | + | ||
- | < | + | |
- | A diversity profile of the human skin microbiota. | + | |
- | Grice EA, Kong HH, Renaud G, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA. | + | |
- | Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. | + | |
- | Abstract | + | |
- | The many layers and structures of the skin serve as elaborate hosts to microbes, including | + | |
- | PMID: 18502944 | + | |
- | + | ||
- | Many lines of evidence suggest a role for microorganisms even in noninfectious skin diseases, such as atopic dermatitis (AD; eczema), rosacea, psoriasis, and acne (Holland et al. 1977; Thomsen et al. 1980;Till et al. 2000; Paulino et al. 2006).</ | + | |
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- | ===== Types ===== | + | |
- | * psoriasis | + | |
- | * vitilligo | + | |
- | * lupus pernio | + | |
- | – rash and itching | + | |
- | – lumps | + | |
- | + | ||
- | Evidence of infectious cause | + | |
- | | + | |
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- | Management | + | |
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- | Patients experiences | + | |
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- | ===== Atopic dermatitis ===== | + | |
- | + | ||
- | < | + | |
- | 4. | + | |
- | Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin. | + | |
- | Gambichler T, Skrygan M, Tomi NS, Othlinghaus N, Brockmeyer NH, Altmeyer P, Kreuter A. | + | |
- | Int Arch Allergy Immunol. 2008; | + | |
- | PMID: 18446049 [PubMed - indexed for MEDLINE] | + | |
- | Related citations Remove from clipboard | + | |
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- | The role of antimicrobial peptides in human skin and in skin infectious diseases. | + | |
- | Schittek B, Paulmann M, Senyürek I, Steffen H. | + | |
- | Infect Disord Drug Targets. 2008 Sep; | + | |
- | PMID: 18782030 [PubMed - indexed for MEDLINE] | + | |
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- | + | ||
- | </ | + | |
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- | ===== Vitiligo ===== | + | |
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- | The skin symptom of vitilligo has been reported by persons on the MP. Some have reported improvement while on the MP. It may simply be another symptom of autoimmune disease. | + | |
- | + | ||
- | * [[http:// | + | |
- | * [[http:// | + | |
- | * [[http:// | + | |
- | * [[http:// | + | |
- | * | + | |
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- | ===== Comorbidities ===== | + | |
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- | < | + | |
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- | Link between thyroid autoimmunity and acne uncovered | + | |
- | By Helen Albert | + | |
- | 06 May 2011 | + | |
- | J Eur Acad Dermatol Venereol 2011: Advance online publication | + | |
- | MedWire News: Women with acne may be more likely to have thyroid autoimmunity than healthy controls, suggest study results. | + | |
- | Thyroid hormones are thought to have an effect on the sebaceous glands, but the role the thyroid gland and its hormones may play in | + | |
- | the pathogenesis of acne is not entirely clear. | + | |
- | Theognosia Vergou (Athens University School of Medicine, Greece) therefore investigated whether 107 adult women with acne were | + | |
- | more or less likely than 60 healthy controls to have a dysfunctional thyroid. The women were aged 24.5 years on average. | + | |
- | Following measurement of C-reactive protein (CRP) and various thyroid hormones and antibodies, the team found that significantly | + | |
- | more of the women with acne had raised (>40 U/ml) antithyroglobulin antibodies (anti-TG) than the controls, at 25.2% versus 8.3%. | + | |
- | This translated to a significant 3.89-fold increase in risk for having high levels of anti-TG in acne patients versus healthy controls | + | |
- | independent of age. | + | |
- | Of note, all except one of the women with acne and high-TG also had higher levels of CRP than the median value for all the acne | + | |
- | patients of 0.57 mg/dl. | + | |
- | Levels of other thyroid hormones and antibodies, namely, triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone, free T3, | + | |
- | free T4, and anti-thyroid peroxidase antibodies, did not differ significantly between the two groups. Thyroid ultrasound findings were | + | |
- | also similar between acne patients and controls. | + | |
- | "One possible mechanism that could explain the observed associations would be through the involvement of cytokines," | + | |
- | authors, | + | |
- | " | + | |
- | observed association of anti-TG autoantibodies with the presence of acne in adult women might point to an involvement of the | + | |
- | inflammatory process in both entities," | + | |
- | "It is likely that thyroid autoimmunity might be more frequent in the adult acne patients … and this should be kept in mind when | + | |
- | screening adult women with acne," conclude Vergou and co-authors in the Journal of the European Academy of Dermatology and | + | |
- | Venereology. | + | |
- | MedWire (www.medwire-news.md) is an independent clinical news service provided by Springer Healthcare Limited. © Springer | + | |
- | Healthcare Ltd; 201</ | + | |
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- | ===== Cutaneous manifestations of immunopathology | + | |
- | + | ||
- | Cutaneous immunopathology | + | |
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- | The body of folks with systemic Th1 infection severe enough to cause sarcoid granuloma is going to exhibit wierd physical phenomena as it heals. These include spots on the skin which are often red. Although these manifestations | + | |
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- | Pigmentation | + | |
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- | As the skin recovers from inflammation, | + | |
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- | Post-Inflammatory Hyperpigmentation | + | |
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- | Darker skin that develops at the site of inflammation is called hyperpigmentation may remain in the area that was injured or inflamed. The darker skin will have a mottled appearance or indistinct border. | + | |
- | + | ||
- | There are two possible causes thought to be responsible for this sort of hyperpigmentation. When the skin looks dirty brown, it is because inflammation and the healing process deranged some of the cells producing melanin to color (pigment) the skin. If the skin is reddish brown, it may be due to deposits of haemosiderin | + | |
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- | Post-inflammatory Hypopigmentation | + | |
- | + | ||
- | Lighter skin found in place following healing from inflammation is called hypopigmentation. It develops because the cells that produce melanin have been injured or destroyed in the healing process. | + | |
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- | Care of Hyperpigmented or Hypopigmented Skin | + | |
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- | Cosmetics may help cover a discoloration. Use moisturizers as needed and avoid sunlight and extreme heat. Consult your physician if you continue to have concerns. | + | |
- | + | ||
- | ===== Lupus pernio ===== | + | |
- | + | ||
- | Lesions on the face that occur or exacerbate when it's cold or windy can be what is called lupus pernio. Lupus Pernio is a skin manifestation of sarcoidosis. Lupus Pernio is not another disease (and is not related to lupus), it's simply a name for the red-to purplish lesions that can appear on the nose, face, ears or hands of sarcoidosis patients. These lesions can occur when the nose, face or hands are exposed to cold or wind, so it's a good idea for sarcies to keep these areas protected from wind and cold. Avoiding exposure to bright lights is also an important preventative measure. | + | |
- | + | ||
- | Lupus pernio, first described by Ernest Besnier, is the most characteristic of all sarcoid lesions. Lupus Pernio is a skin manifestation of sarcoidosis. Lupus Pernio is not another disease (and is not related to lupus), it's simply a name for the red-to purplish lesions that can appear on the nose, face, ears or hands of sarcoidosis patients. These lesions can occur when the nose, face or hands are exposed to cold or wind, so it's a good idea for sarcies to keep these areas protected from wind and cold. Avoiding exposure to bright lights is also an important preventative measure. | + | |
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- | Sometimes lupus pernio lesions will have an appearance of small " | + | |
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- | Like some other cutaneous sarcoidosis lesions, lupus pernio can appear at sites of old scars or trauma. | + | |
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- | Lupus pernio lesions, like other sarcoid manifestations | + | |
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- | Lupus pernio is said to be the skin lesion most characteristic (a diagnostic indicator) | + | |
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- | ==== Patients experiences ==== | + | |
- | + | ||
- | < | + | |
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- | Warning of the risk of scarring, whether on the skin or in the lungs, is a common tactic to pressure | + | |
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- | // | + | |
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- | Skin rash | + | |
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- | This article by a practicing dermatologist explains that both " | + | |
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- | Erythema nodosum | + | |
- | + | ||
- | Erythema Nodosum is a common manifestation of acute sarcoidosis. | + | |
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- | Subcutaneous Nodules | + | |
- | + | ||
- | Subcutaneous nodular sarcoid lesions are sometimes called Darier-Roussy sarcoidosis, named for the French physicians Darier and Roussy who described these subcutaneous nodules in 1904. | + | |
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- | Skin tags | + | |
- | + | ||
- | Here is a photo of skin tags. | + | |
- | + | ||
- | According to this source, alternate names for skin tags are: | + | |
- | * Acrochordons | + | |
- | * Papillomas | + | |
- | * Soft fibromas | + | |
- | * Pedunculated (this means they are on a stalk) | + | |
- | * Filiform (this means they are thread-like) | + | |
- | + | ||
- | "Skin tags develop in both men and women as they grow older. They are skin coloured or darker and range in size from 1mm to 5cm. They are most often found in the skin folds (neck, armpits, groin). They tend to be more numerous in obese persons and in those with type 2 diabetes mellitus." | + | |
- | + | ||
- | Sarcoidosis manifests in a wide variety of skin lesions. You can find links to photos of cutaneous sarcoidosis on this SarcInfo thread. Here is a photo of sarc lesions around the eye. | + | |
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- | Lesions | + | |
- | + | ||
- | Some of the types of skin lesions encountered in sarcoidosis, | + | |
- | Papules (little bumps) resembling | + | |
- | Granulomatous rosacea | + | |
- | Acne | + | |
- | Benign appendageal tumors | + | |
- | + | ||
- | Plaques resembling | + | |
- | Psoriasis | + | |
- | Lichen planus | + | |
- | Nummular eczema | + | |
- | Discoid lupus | + | |
- | erythematosus | + | |
- | Granuloma annulare | + | |
- | Cutaneous T-cell lymphoma | + | |
- | Kaposi' | + | |
- | Secondary syphilis | + | |
- | + | ||
- | Lupus pernio resembling | + | |
- | Scar | + | |
- | Discoid lupus erythematosus | + | |
- | (more info on lupus pernio can be found in a later post) | + | |
- | + | ||
- | Erythema nodosum resembling | + | |
- | Cellulitis | + | |
- | Furunculosis | + | |
- | Other inflammatory panniculitis | + | |
- | + | ||
- | Sarcoid skin lesions can be painful, itchy, oozy or dry and peeling. They can also make your hair fall out. You can find more information and lots of pictures of skin sarcoidosis (to compare with your rashes) in the thread "Skin Sarc, What Does it Look Like?" or Images of cutanenous sarcoidosis. | + | |
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- | ===== Skin lesions ===== | + | |
- | + | ||
- | ==== Patients experiences ==== | + | |
- | + | ||
- | < | + | |
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- | //**sd**, MarshallProtocol.com//</ | + | |
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- | The lumps under my skin are worse. Will the MP make them go away? | + | |
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- | Q: I have noticed additional granulomas forming and they seem to be getting larger (just under the skin) and very painful. Will the formation of these stop while on the MP? Sure hope so. I am not going to get any more injections into the sites because that seems to only have more form within just a month or two. | + | |
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- | A: Firm, tender lumps under the skin are usually called nodules. Sarcoid granulomas are microscopic, | + | |
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- | It is not unusual to experience | + | |
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- | Belinda | + | |
- | + | ||
- | For more information about granulomas see Diagnosis in the SARCOIDOSIS thread. | + | |
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- | and Why Does the Body Make Granulomas? | + | |
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- | ===== Managing skin symptoms ===== | + | |
- | + | ||
- | "Skin eruptions" | + | |
- | + | ||
- | Dr Marshall says of the skin: "Every Th1 patient has inflammation in their skin. Dr Alan Cantwell observed many years ago that these bacteria loved the sweat glands, and suggested that a punch biopsy ought to be good enough to confirm Th1 inflammation. Take a look at: | + | |
- | + | ||
- | " | + | |
- | Shingles (Click on link to see information) | + | |
- | + | ||
- | Immunopathology | + | |
- | + | ||
- | Since we know that we are dealing with intracellular bacteria in the Th1 diseases, the logical reason for these ' | + | |
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- | Immunopathology is expected to cause fluctuations in your blood tests. It is expected and encouraged that patients on the MP will be monitored by their primary care provider who will order tests appropriate to monitor general health. You may like to ask Dr to keep an eye on your thyroid levels. | + | |
- | + | ||
- | This SarcInfo thread, Skin sarc, what does it look like? has many links to photos of skin lesions. | + | |
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- | Neurological immunpathology that affects the brain can cause various skin sensations. | + | |
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- | Reduce immunopathology | + | |
- | + | ||
- | Relief of immunopathology symptoms is obtained by increasing the frequency of Benicar and discontinuing or altering the antibiotic schedule. Please see My immune reaction is too strong. What should I do? | + | |
- | + | ||
- | Or you may need to proceed more slowly with lower doses of antibiotics. Let us know if you need help modifying your antibiotics regime or Benicar schedule in order to manage your immune system reactions. I'm eager to get well. How can I speed up my progress on the MP? | + | |
- | + | ||
- | Quercetin: may be helpful once established on MP | + | |
- | + | ||
- | If your cutaneous immunopathology is tolerable, you can ignore it, or, you may wish to treat it palliatively until it resolves, while continuing the MP. | + | |
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- | Over the counter relief of itching | + | |
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- | Itching is the most common complaint with a skin rash. Benadryl is an over-the-counter antihistamine that will relieve itchiness. The oral medication causes sleepiness so it might be contraindicated during the daytime but it can be particularly useful at bedtime. | + | |
- | + | ||
- | -Over-the-counter topical preparations to reduce itching are sometimes helpful. | + | |
- | -Benadryl cream has worked better for some than cortisone cream for just about any kind of skin lesion, whether it's something that " | + | |
- | -If using a hydrocortisone OTC use it sparingly. Tissues treated with steroids do not heal well and all steroids are absorbed systemically. | + | |
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- | Prescription oral medication to relieve itching | + | |
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- | You may get relief from intolerable itching with Cyproheptadine, | + | |
- | + | ||
- | ===== Other treatments ===== | + | |
- | + | ||
- | ==== Steroids ==== | + | |
- | Topical steroids | + | |
- | + | ||
- | Topical steroid creams are available OTC and may be needed to relieve intolerable itching. Use them sparingly. | + | |
- | + | ||
- | If intolerable itching is not helped by OTC steroid cream, talk to your doctor about a prescription strength topical corticosteroid preparation and use it sparingly. | + | |
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- | All topical corticosteroids are absorbed through the skin and enter the circulation. See for example this report of a person who lost their femoral head joint (hip) due to steroidal cream being applied to the face: | + | |
- | http:// | + | |
- | + | ||
- | All steroids are bad in high dose - they differ only in their efficacy vs dose characteristics. So if you have to use them, then please do it very sparingly. Additionally, | + | |
- | ..Trevor.. | + | < |
- | Itching due to liver disease | + | //**Trevor Marshall, PhD**//</ |
- | I remember when I was a child, my grandma used to tell me not to scratch my skinned knees but to be happy the itching was a sign of healing. | ||
- | You may not have realized that intense itching can be secondary to liver disease. That doesn' | + | ===== Managing skin symptoms ===== |
- | Here is some interesting information from a researcher who is investigating how liver-related itching is mediated in the brain. | + | Patients whose cutaneous immunopathology |
+ | ==== Topical steroids ==== | ||
- | Avoid toxic exposures | + | As is the case with other immunosuppressive medications, |
- | I would suggest that the patient ensure that they avoid any other toxic exposure such as cleaning products, chemicalized foods, unnecessary meds supplements etc. plus adjust lifestyle | + | < |
- | The MP will resolve | + | All topical corticosteroids are absorbed through the skin and enter the circulation. See for example this report of a person who lost their femoral head joint (hip) due to steroidal cream being applied to the face.(({{pubmed> |
- | It is not just the collagen | + | All steroids are bad in high dose – they differ only in their efficacy vs dose characteristics. So if you have to use them, then please do it very sparingly. Additionally, |
- | See also: | + | //**Trevor Marshall**//</ |
+ | ==== Over the counter remedies ==== | ||
- | ===== Over the counter | + | Benadryl is an over-the-counter |
+ | < | ||
- | ==== Itchy skin ==== | + | // |
- | < | + | < |
// | // | ||
- | < | + | < |
// | // | ||
- | < | + | < |
//**Mel (shadowfeet)**, | //**Mel (shadowfeet)**, | ||
- | < | + | < |
//**Gail**, MarshallProtocol.com//</ | //**Gail**, MarshallProtocol.com//</ | ||
+ | < | ||
+ | // | ||
- | ==== Dry skin ==== | ||
- | < | + | < |
//**Meg**, MarshallProtocol.com//</ | //**Meg**, MarshallProtocol.com//</ | ||
- | < | + | < |
//**Joy**, MarshallProtocol.com//</ | //**Joy**, MarshallProtocol.com//</ | ||
- | < | + | < |
//**Aunt Diana**, MarshallProtocol.com//</ | //**Aunt Diana**, MarshallProtocol.com//</ | ||
- | ==== Itchy scalp ==== | + | ==== Lotions and ointments |
- | < | ||
- | //****, MarshallProtocol.com// | + | < |
+ | Although the skin problem is likely due to immunopathology, | ||
+ | For years, I have been using 100% pure glycerin (from a drug store or health food store). This is the part of many of the best moisturizers that really does the most effective moisturizing. I then add about 1/3 to ½ part water and it makes a nice soothing moisturizer. | ||
- | I had lots of itching and breaking out (skin sarcs) got worse...all herx sxs. Benadryl cream (slathered entire areas) and 2% Ketoconzole cream (treated spots only) worked great to relieve | + | Another place with good products for the sensitive is Special Foods (visit the [[http:// |
- | ==== Psoriasis ==== | + | For a lotion, they may be rather expensive and perhaps there would be other options for hypoallergenic lotions at a health food store if you want to order it (try needs.com), or just using a hypoallergenic vegetable oil? You could try more than one option. Also, in case you might have become sensitive to the soap you are using, there is a pure glycerin unscented soap at the health food store that I like called Clearly Natural glycerin soap. |
+ | //**Joyce Waterhouse, Ph.D.**, MarshallProtocol.com//</ | ||
- | < | + | < |
+ | Trader Joe's has a Liquid Glycerin Soap and also a solid bar of Glycerin Soap. If you have a store near you, take a look for these options. | ||
- | //**Reenie**, MarshallProtocol.com//</ | + | //**Trevor Marshall, Ph.D.**, MarshallProtocol.com//</ |
- | ==== Raw skin lesions ==== | + | < |
+ | [[http:// | ||
- | < | + | //**P.B.**, MarshallProtocol.com// |
- | //****, MarshallProtocol.com//</ | ||
+ | ==== Pigmentation ==== | ||
+ | As the skin recovers from inflammation, | ||
- | I've had good results applying Campho-Phenique (for lip Cold Sores) on my raw skin lesions when not able to use Benadryl. This OTC medicine stops the itching and burning fast. ~Donna | ||
- | Scars, skin tags and moles | ||
- | I have several scars on my hands that have turned a little brown some of them even a little red. One of them has been there since I was a kid and it is even starting to level out it used to stick up a little bit. I've had fifteen or more skin tags fall off. I've had small moles disappear and my larger ones are about the size of my small ones. Mine all started improving in the higher up on phase two. I am having all kind of crazy stuff on my skin happen right now dark spots coming and going, rashes, try spots but none of it is lasting more than a couple weeks. ~Ival | ||
- | About a month ago I had a mole on my arm just turn to a sort of sludge and dissapear. It felt itchy one day and I just wiped it off with a handkerchief. It left a small hole (about 6mm by 9mm), very clean on the bottom, and that healed up quickly and looks like it will leave no scar. I'm assuming my immune system took a dislike to this mole! | + | ==== Avoid toxic exposures ==== |
- | Just FYI, the other two chronic lesions on my arms have also healed since I started | + | < |
- | A few days ago I noticed several small red, raw spots on the side of my face. I wondered how they got there. Only today did I recall that these are at the sites of some tiny moles (I prefer to call them beauty marks). ~Carol | + | //**Greg Blaney, M.D.**//</ |
- | Hypopigmentation | ||
- | My experience with skin lesions goes back to when I was age six. I often had temporary hypopigmentation as a result of bouts with rashes. | ||
- | The healing of your recent outbreak of psoriasis is a plausible explanation for your hypopigmentation. The Merk Manual explains that post-inflammatory hypopigmentation may be a result of healing of certain inflammatory disorders and spontaneous repigmentation may occur. I found that it might take a month or two, but my normal pigmentation always did return. Take heart in the fact that this is not always a permanent condition. | ||
- | While your skin is still healing, cosmetics can make the altered pigmentation less noticeable. In fact, it's much easier to cover hypopigmentation appearing on the face than if it's on the hands, arms or legs. | ||
- | I guess you will just have to wait and see, but in the early stages of healing, the hypopigmentation may look as if it is spreading. ~Belinda | + | ===== Patients experiences ===== |
- | Many of the white areas on my skin have disappeared! ~Alayne | ||
+ | ==== Bunions ==== | ||
+ | < | ||
+ | I was genuinely shocked when one day lying on the couch with my feet up and there it was... or wasn' | ||
+ | It hurt, it burnt and it got angry red from time to time but it went. | ||
+ | You have a bunion? | ||
+ | // | ||
- | Dark pigment changes | ||
- | the skin color around my jaw line and chin area was considerably darker than the rest of my face, close in color to what I've termed previously as a " | + | |
+ | ==== Discolored skin ==== | ||
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+ | The skin color around my jaw line and chin area was considerably darker than the rest of my face, close in color to what I've termed previously as a " | ||
Also need to report that the skin on the knuckles of both hands is real dark in comparison to the skin on my fingers. | Also need to report that the skin on the knuckles of both hands is real dark in comparison to the skin on my fingers. | ||
I had previously reported: Small dark spots have appeared on my lower legs with little grain-like round lumps in them. I felt what I initially thought was an insect bite. | I had previously reported: Small dark spots have appeared on my lower legs with little grain-like round lumps in them. I felt what I initially thought was an insect bite. | ||
- | My face is developing more pigment changes, likewise. the left side of my face, mainly forehead, brow area down to cheek is the darkest spot. I too have freckles which seem to be fading, now that I've taken a good look at them. ~Toni D | ||
- | Blue and purple marks | + | My face is developing more pigment changes, likewise. the left side of my face, mainly forehead, brow area down to cheek is the darkest spot. I too have freckles which seem to be fading, now that I've taken a good look at them. |
+ | //**Toni D.**, MarshallProtocol.com//</ | ||
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I think you are the only one Ive read about that has the blue marks appear. I had taken 9 mos of doxy before MP and had been off it quite awhile before I relapsed and that was when I had the purple marks come up all accross the back of my hand. Didn't hurt and I hadn't hit my hand. Slowly faded to a brown then go away. | I think you are the only one Ive read about that has the blue marks appear. I had taken 9 mos of doxy before MP and had been off it quite awhile before I relapsed and that was when I had the purple marks come up all accross the back of my hand. Didn't hurt and I hadn't hit my hand. Slowly faded to a brown then go away. | ||
- | Then I did MP for last two yrs. About six weeks ago I was really pushing to the max herx and had one appear on my wrist near my pulse. It too is now almost gone. I looked online and found some websites that reported people in Europe with Borrellia | + | Then I did MP for last two years. About six weeks ago I was really pushing to the max herx and had one appear on my wrist near my pulse. It too is now almost gone. I looked online and found some websites that reported people in Europe with // |
- | I found the explanation of the skin discoloration that can be from 3rd stage borrellia. See this link. I'm sorry that some of the pictures are so graphic but I wanted to show you to make sure your doctor is just thinking the skin changes you are having are just related to Mino. My purple marks occurred on knuckles of lt hand, wrist, very deliniated | + | I found the explanation of the skin discoloration that can be from third stage // |
- | Bruises, thin skin | + | // |
- | Use of prednisone results in "thin skin" which tears and bruises with even slight trauma. This side effect is covered (with photos) in the this Johns Hopkins webpage. | ||
- | Th1 inflammation can also causes bruises to heal slowly in people who are not on prednisone. | + | < |
+ | Many of the white areas on my skin have disappeared! | ||
- | those very itchy, scabby patches are completely gone. ~Adrianne | + | // |
- | Bunion | ||
- | -Ah bunions....I had a beauty on my right foot. Left foot was normal. | ||
- | I was genuinely shocked when one day lying on the couch with my feet up and there it was..... or wasn' | + | ==== Hemangioma ==== |
- | It hurt, it burnt and it got angry red from time to time but it went. | + | < |
- | You have a bunion? | + | // |
- | Hemangioma | ||
- | -In my last report I forgot to tell you the most visible improvement. I have/had haemangioma on my upper legs. Left it is a myriad of threads and spots, difficult to say how much it is decreased. On my right leg it was a big united round spot of about 70 cm2. Now it is about 7 cm2. On my under legs I had some ACA. It diminishes in the same way. ACA is seen in Europe as a very late -after 20 years or more- symptom of Borrelia Afzelii. ~Han.V Netherlands | + | ==== Lesions ==== |
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- | Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment | + | |
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- | * f90 | + | |
- | f91: | + | All this has made me contact the skin and cancer foundation of Australia where I originally went and got my diagnosis of sarcoidosis 8 years ago. I spoke to them and told them about all this. It flew over there heads but they are willing to see me because my case was very interesting for them at the time and I think they want to know how all this stuff works because I'm the living proof of the MP working. |
- | Skin products for sensitive skin | + | // |
- | Although the skin problem is likely due to immunopathology, | ||
- | For years, I have been using 100% pure glycerin (from a drug store or health food store). This is the part of many of the best moisturizers | + | < |
- | Another place with good products for the sensitive is Special Foods (web site: http://www.specialfoods.com and click on products or call 703-644-0991), | + | //**sd**, MarshallProtocol.com//</ |
- | For a lotion, they may be rather expensive and perhaps there would be other options for hypoallergenic lotions at a health food store if you want to order it (try needs.com) -- or just using a hypoallergenic vegetable oil?-- you could try more than one option. Also, in case you might have become sensitive to the soap you are using, there is a pure glycerin unscented soap at the health food store that I like called Clearly Natural glycerin soap. | ||
- | Joyce Waterhouse, Ph.D. | + | < |
- | .......................................................................... | + | //**P.B.**, MarshallProtocol.com//</ |
- | Trader Joe's has a Liquid Glycerin Soap and also a solid bar of Glycerin Soap. If you have a store near you, take a look for these options. ..Trevor.. | ||
- | ............................................................................. | + | ==== Lupus pernio ==== |
- | Aubrey Organics http:// | + | < |
- | ............................................................................ | + | Warning of the risk of scarring, whether on the skin or in the lungs, is a common tactic to pressure patients to use the treatment a physician prefers. < |
- | See Unscented Products for those with MCS | + | //**Belinda**, MarshallProtocol.com//</ |
- | MCS improvements | + | |
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- | e248: | ||
- | The skin symptom Vitiligo may simply be another symptom of your disease. Some of us have had this depigmentation effect, too. We offer these citations for consideration. | ||
- | http:// | + | ==== Scars ==== |
- | Autoimmune aspects of depigmentation in vitiligo. | + | |
- | http:// | ||
- | Subcutaneous sarcoidosis associated with vitiligo, pernicious anaemia and autoimmune thyroiditis. | ||
- | http:// | + | < |
- | Cutaneous manifestations | + | |
- | NALP1 in Vitiligo-Associated Multiple Autoimmune Disease | + | //**Aunt Diana**, MarshallProtocol.com//</ |
- | Conclusions DNA sequence variants in the NALP1 region are associated with the risk of several epidemiologically associated autoimmune and autoinflammatory diseases, implicating the innate immune system in the pathogenesis of these disorders. http:// | ||
- | ____________________ | + | < |
- | Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| 24+ years not Dx| MP Aug04 | + | |
- | | + | //**Ival**, MarshallProtocol.com//</ |
- | + | ||
- | ===== Patients experiences ===== | + | < |
- | ==== Improvements in skin conditions ==== | + | Just FYI, the other two chronic lesions on my arms have also healed since I started the MP (they were sores that scarred up, then they would crack open and bleed spontaneously and then erode to a sore again, over and over for about 3 years) There is a very little scarring there now, but it's just a mark and not the thick knob of scar that it used to form between breakouts. |
- | -Another great thing that is happening to me is my granulomatous raised red skin lesions that had covered 80% of by body has literally cleared up. It's flattened out and browned back to nearly my original olive skin colour. | + | // |
- | All this has made me contact the skin and cancer foundation of Australia where I originally went and got my diagnosis of Sarcoid 8 years ago. I spoke to them and told them about all this. It flew over there heads but they are willing to see me because my case was very interesting for them at the time and I think they want to know how all this stuff works because I'm the living proof of the MP working.~Simon Elrahi | ||
- | I had many skin lesions come and go in first year of MP, and just two month ago had a large raised lesion (AK) just slough off and disappear. ~ P.B. | + | < |
- | I have had some interesting changes in areas where I had sun damaged skin. Particularly my neckline and the backs of my hands. At first, the MP seemed to exacerbate the redness in these areas, especially my neckline. For the first two years the skin was very red and irritated. But recently, I've started to notice it feeling much softer to the touch. There seems to be a new layer of fat making the skin feel much softer and the irritation has disappeared. I find myself constantly wanting to touch this skin it is so soft...it is an amazing difference.~ Aunt Diana | + | //**Carol**, MarshallProtocol.com//</ |
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | |||
+ | < | ||
+ | Curr Pharm Des. 2006; | ||
+ | Functional genome and proteome analyses of cutaneous autoimmune diseases. | ||
+ | Trcka J, Kunz M. | ||
+ | Source | ||
+ | Department of Dermatology and Venerology, University of Rostock, 18055 Rostock, Germany. | ||
+ | Abstract | ||
+ | The use of functional genomics and proteomics technologies has dramatically increased through recent years with a special emphasis on cancer biology. However, a series of more recent reports has also addressed inflammatory diseases. These included studies on different autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus, | ||
+ | PMID: 17073677 | ||
+ | </ | ||
===== References ===== | ===== References ===== |