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home:tests:125d [10.12.2018] – [Read more] sallieqhome:tests:125d [09.14.2022] (current) – external edit 127.0.0.1
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 <relatedarticles> [[home:tests:25d|Test: 25-D]], [[home:pathogenesis:vitamind:metabolism|Metabolism of vitamin D and the Vitamin D Receptor]] </article> <relatedarticles> [[home:tests:25d|Test: 25-D]], [[home:pathogenesis:vitamind:metabolism|Metabolism of vitamin D and the Vitamin D Receptor]] </article>
  
-Also known as 1,25-dihydroxyvitamin D, 1,25-D is the active form of vitamin D, binding to and activating the Vitamin D Nuclear Receptor (VDR). 1,25-D is classified as a secosteroid and is tightly regulated by the body as are all the other hormones.(({{pubmed>long:19444938}})) For example, one study showed that patients given 800 IU/day of vitamin D for six weeks did not show any increase in blood levels of 1,25-D.(({{pubmed>long:18754003}}))+Also known as 1,25-dihydroxyvitamin D, 1,25-D is the active form of vitamin D, binding to and activating the Vitamin D Nuclear Receptor (VDR). 1,25-D is classified as a secosteroid and is tightly regulated by the body as are all the other hormones.(({{pmid>long:19444938}})) For example, one study showed that patients given 800 IU/day of vitamin D for six weeks did not show any increase in blood levels of 1,25-D.(({{pmid>long:18754003}}))
    
  
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-In the context of the Marshall Protocol (MP), a 1,25-D test is largely useful at a single point in time: prior to beginning the therapy and as a general measure of overall inflammation. After starting the MP, regular dosing of olmesartan (Benicar) cuts levels of 1,25-D by as much as 50% in a week's time.+In the context of the Marshall Protocol (MP), a 1,25-D test is largely useful at a single point in time: prior to beginning the therapy and as a general measure of overall inflammation. After starting the MP, regular dosing of olmesartan (Benicar) may cut levels of 1,25-D by as much as 50% in a week's time.
  
 ==== Of special note for women ==== ==== Of special note for women ====
  
-By their nature, levels of 1,25-D naturally fluctuate. Women who are interested in knowing their highest level of 1,25-D should have their blood drawn mid-cycle around Day 15 or so. This is at least according to one very small 1982 study, which demonstrated that the serum concentration of 1,25-D fluctuated with the menstrual cycle.(({{pubmed>long:6897337}})) Levels of 1,25-D were shown to be dramatically higher near ovulation in women not on the pill. +By their nature, levels of 1,25-D naturally fluctuate. Women who are interested in knowing their highest level of 1,25-D should have their blood drawn mid-cycle around Day 15 or so. This is at least according to one very small 1982 study, which demonstrated that the serum concentration of 1,25-D fluctuated with the menstrual cycle.(({{pmid>long:6897337}})) Levels of 1,25-D were shown to be dramatically higher near ovulation in women not on the pill. 
  
 The higher the level, the more persuasive the evidence of Th1 inflammation will be for a doctor.  The higher the level, the more persuasive the evidence of Th1 inflammation will be for a doctor. 
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-MP patients getting their 1,25-D levels tested should ensure the [[home:tests:dtesting|relevant instructions]] are closely followed including the freezing of blood samples. Over the course of at least 72 hours, 1,25-D does not appear to be degraded to any significant degree when stored at 24°C.(({{pubmed>long:7226510}}))+MP patients getting their 1,25-D levels tested should ensure the [[home:tests:dtesting|relevant instructions]] are closely followed including the freezing of blood samples. Over the course of at least 72 hours, 1,25-D does not appear to be degraded to any significant degree when stored at 24°C.(({{pmid>long:7226510}}))
  
 ===== Interpreting a 1,25-D test ===== ===== Interpreting a 1,25-D test =====
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 Larger more reliable studies have found that healthy people have lower levels of 1,25-D than standard reference ranges might otherwise suggest.  Larger more reliable studies have found that healthy people have lower levels of 1,25-D than standard reference ranges might otherwise suggest. 
-  * The largest and most reliable published study identifying a valid 1,25-D reference range is a Danish population study.(({{pubmed>long:10602348}})) For non-smokers, the average 1,25-D level was 29.0 pg/ml ± 9.5 pg/ml.  +  * The largest and most reliable published study identifying a valid 1,25-D reference range is a Danish population study.(({{pmid>long:10602348}})) For non-smokers, the average 1,25-D level was 29.0 pg/ml ± 9.5 pg/ml.  
-  * A small study confirms these lower values when reporting a mean of 23.6 ± 1.3 pg/ml for 1,25-D in controls.(({{pubmed>long:6332830}}))+  * A small study confirms these lower values when reporting a mean of 23.6 ± 1.3 pg/ml for 1,25-D in controls.(({{pmid>long:6332830}}))
  
 These ranges are consistent with levels measured from 1,700 patients at the University of Toronto and the Merck's Physicians' Handbook.  These ranges are consistent with levels measured from 1,700 patients at the University of Toronto and the Merck's Physicians' Handbook. 
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   * [[home:pathogenesis:vitamind:forms|Forms and structure of vitamin D]]   * [[home:pathogenesis:vitamind:forms|Forms and structure of vitamin D]]
 +  * Calcium signalling in cell processes(({{pmid>long:31127110}}))
  
 {{tag>tests}}   {{tag>tests}}  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
   * Legacy content    * Legacy content 
-    * http://www.curemyth1.org/view_topic.php?id=670&forum_id=2  e21+    * https://www.curemyth1.org/view_topic.php?id=670&forum_id=2  e21
     * effect of concurrent viral infection on 1,25-D f321  f343 ?     * effect of concurrent viral infection on 1,25-D f321  f343 ?
     * high initial 1,25-D mean less IP? f326     * high initial 1,25-D mean less IP? f326
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     * Quest diagnostics  e22 e26 e27     * Quest diagnostics  e22 e26 e27
  
-===== References =====+===== References =====</nodisp> 
home/tests/125d.txt · Last modified: 09.14.2022 by 127.0.0.1
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