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--- home:tests:kidney [10.12.2018] – [Comment] sallieq
+++ home:tests:kidney [09.14.2022] (current) – external edit 127.0.0.1
@@ Line 24: / Line 24: @@
 Olmesartan has two key properties: Vitamin D Receptor agonist and potent anti-inflammatory. While it may seem logical to discontinue olmesartan given that it stimulates the immune response, leading to immunopathology and subsequently elevated kidney values, abruptly withdrawing olmesartan can be dangerous.
-By reducing inflammation, olmesartan offers ongoing protection to the kidneys even while it is stimulating the VDR.(({{pubmed>long:13679467}})) (({{pubmed>long:16601581}})) When the medication is discontinued, the patient's symptoms of disease can become significantly worse as olmesartan's anti-inflammatory protection is withdrawn. This is because while the drop in inflammation is immediate, the immune response which has been accelerated by olmesartan will continue to be strong even days, weeks, or months after [[home:mp:break#weaning_olmesartan_when_necessary|discontinuing olmesartan]].
+By reducing inflammation, olmesartan offers ongoing protection to the kidneys even while it is stimulating the VDR.(({{pmid>long:13679467}})) (({{pmid>long:16601581}})) When the medication is discontinued, the patient's symptoms of disease can become significantly worse as olmesartan's anti-inflammatory protection is withdrawn. This is because while the drop in inflammation is immediate, the immune response which has been accelerated by olmesartan will continue to be strong even days, weeks, or months after [[home:mp:break#weaning_olmesartan_when_necessary|discontinuing olmesartan]].
 Instead of discontinuing olmesartan, physicians are advised to work with their patients to employ [[home:mp:managing_immunopathology|one of several strategies]] to reduce the immunopathological response. Reducing, but not discontinuing entirely, antibiotics has often proven helpful.
@@ Line 33: / Line 33: @@
 The benefits of olmesartan on patients with kidney inflammation include:
-  * decreased insulin resistance, fewer symptoms of the metabolic syndrome, and decreased inflammation in patients with chronic kidney disease.(({{pubmed>long:17130263}}))
+  * decreased insulin resistance, fewer symptoms of the metabolic syndrome, and decreased inflammation in patients with chronic kidney disease.(({{pmid>long:17130263}}))
-  * the ability to ameliorate renal injury and fibrosis in rats when taken at ultrahigh doses.(({{pubmed>long:16755152}}))
+  * the ability to ameliorate renal injury and fibrosis in rats when taken at ultrahigh doses.(({{pmid>long:16755152}}))
-  * decreased (intra)renal vascular resistance, increased renal perfusion, and significantly reduced oxidative stress in patients with type 2 diabetes(({{pubmed>long:15716329}}))
+  * decreased (intra)renal vascular resistance, increased renal perfusion, and significantly reduced oxidative stress in patients with type 2 diabetes(({{pmid>long:15716329}}))
-  * protection of the kidneys in diabetic nephropathy(({{pubmed>long:16755152}}))
+  * protection of the kidneys in diabetic nephropathy(({{pmid>long:16755152}}))
-  * offer a survival benefit in hemodialysis patients, may help in preservation of renal function in predialysis patient, and  affect the tissue repair process, reducing renal fibrosis(({{pubmed>long:20540037}}))
+  * offer a survival benefit in hemodialysis patients, may help in preservation of renal function in predialysis patient, and  affect the tissue repair process, reducing renal fibrosis(({{pmid>long:20540037}}))
 ===== Recent studies of Olmesartan in patients =====
@@ Line 46: / Line 46: @@
 For MP patients with disease involvement in the kidneys, kidney-specific metabolites may increase in a way that is consistent with an active or activated immune response. The following research support this idea:
-  * **BUN** – One study found that hemodialysis patients who had high serum values of urea nitrogen (BUN) were less likely to have the acute infection, //Helicobacter pylori//.(({{pubmed>long:14696511}})) This suggests that temporary markers of kidney stress such as BUN may correlate with a robust and successful immune response.
+  * **BUN** – One study found that hemodialysis patients who had high serum values of urea nitrogen (BUN) were less likely to have the acute infection, //Helicobacter pylori//.(({{pmid>long:14696511}})) This suggests that temporary markers of kidney stress such as BUN may correlate with a robust and successful immune response.
-  * **creatinine** – According to Goldstein, clinicians caring for patients with acute kidney injury (AKI) have been hindered by the reliance on serum creatinine or decreased urine output, both kidney function markers, to make the AKI diagnosis. Even more vexing is the fact that similar serum creatinine changes can occur without kidney damage, for example in the context of dehydration, nephrotic syndrome or hepatorenal syndrome.(({{pubmed>long:22189039}}))
+  * **creatinine** – According to Goldstein, clinicians caring for patients with acute kidney injury (AKI) have been hindered by the reliance on serum creatinine or decreased urine output, both kidney function markers, to make the AKI diagnosis. Even more vexing is the fact that similar serum creatinine changes can occur without kidney damage, for example in the context of dehydration, nephrotic syndrome or hepatorenal syndrome.(({{pmid>long:22189039}}))
-In a 2011 study appearing in //Kidney International//, Agarwal //et al.// gave 16 patients with chronic kidney disease daily doses of paricalcitol, an orally active vitamin D receptor (VDR) activator.(({{pubmed>long:21716260}})) (Note that the VDR plays a key role in innate immunity.) The vitamin D analog was stopped after four days, and measurements were continued for three. During therapy, researchers found that subjects' serum creatinine significantly increased at a rate of 0.010 mg/dl/day and urine creatinine at a rate of 17.6 mg/day. Researchers also found a small increase in blood levels of BUN.
+In a 2011 study appearing in //Kidney International//, Agarwal //et al.// gave 16 patients with chronic kidney disease daily doses of paricalcitol, an orally active vitamin D receptor (VDR) activator.(({{pmid>long:21716260}})) (Note that the VDR plays a key role in innate immunity.) The vitamin D analog was stopped after four days, and measurements were continued for three. During therapy, researchers found that subjects' serum creatinine significantly increased at a rate of 0.010 mg/dl/day and urine creatinine at a rate of 17.6 mg/day. Researchers also found a small increase in blood levels of BUN.
@@ Line 55: / Line 55: @@
 In conclusion, VDR activation may alter creatinine metabolism. An increase in creatinine generation may lead to an increase in serum creatinine and, if eGFR is used to measure kidney function, it may give the appearance that kidney function is declining when truly it may not be altered.
-//**Rajiv Agarwal** et al.//(({{pubmed>long:21716260}}))
+//**Rajiv Agarwal** et al.//(({{pmid>long:21716260}}))
 </blockquote>
@@ Line 111: / Line 111: @@
  <blockquote>when used between 10–100 mM, suppression of growth and killing of all bacterial species were observed including not only drug-resistant strains, such as methicillin-resistant Staphylococcus aureus, but also uncharacterized environmental bacterial strains as well. The mechanism of action is as yet unclear.
-Creatinine inhibits bacterial replication //Thomas McDonald, Kristen M Drescher, Annika Weber and Steven Tracy//  2012  (({{pubmed>long:22293916}}))</blockquote>
+Creatinine inhibits bacterial replication //Thomas McDonald, Kristen M Drescher, Annika Weber and Steven Tracy//  2012  (({{pmid>long:22293916}}))</blockquote>
+[{{home:tests:kidney_tests.gif}}]
 {{tag>tests kidneys}}
+<nodisp>
 ===== Notes and comments =====
@@ Line 121: / Line 127: @@
 This article talks about how bacteria can lead to release of nitric oxide:
-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC118062/
+https://www.ncbi.nlm.nih.gov/pmc/articles/PMC118062/
-Blood Urea Nitrogen test is [[http://labtestsonline.org/understanding/analytes/bun/test.html|described here]].
+Blood Urea Nitrogen test is [[https://labtestsonline.org/understanding/analytes/bun/test.html|described here]].
@@ Line 156: / Line 162: @@
-<blockquote>http://www.medicalnewstoday.com/releases/231646.php
+<blockquote>https://www.medicalnewstoday.com/releases/231646.php
-http://www.cell.com/cell-host-microbe/abstract/S1931-3128(11)00194-6
+https://www.cell.com/cell-host-microbe/abstract/S1931-3128(11)00194-6
@@ Line 178: / Line 184: @@
 It is not uncommon for creatinine levels to rise while having immunopathology during the MP. All of the usual methods for [[:home:mp:managing_immunopathology|managing immunopathology]] should be employed.
-The creatinine test is [[http://labtestsonline.org/understanding/analytes/creatinine/test.html|described here]].
+The creatinine test is [[https://labtestsonline.org/understanding/analytes/creatinine/test.html|described here]].
-A good article to review is "[[http://bacteriality.com/2008/02/23/misconceptions/#6|Misconception #6:  If my blood work (particularly that which pertains to kidney function) goes out of range after starting the MP, that’s a bad sign.]]" by Amy Proal.
+A good article to review is "[[https://bacteriality.com/2008/02/23/misconceptions/#6|Misconception #6:  If my blood work (particularly that which pertains to kidney function) goes out of range after starting the MP, that’s a bad sign.]]" by Amy Proal.
 Also, for more information, see Dr. Marshall's [[home:publications:marshall_westchina_2008|talk to doctors at West China Hospital]], where he addresses this particular test.
@@ Line 199: / Line 205: @@
 "Elevations in serum creatinine with RAAS blockade: why isn't it a sign of kidney injury?"
-http://www.ncbi.nlm.nih.gov/pubmed/18695383
+https://www.ncbi.nlm.nih.gov/pubmed/18695383
 From Gary's progress (garyv).
-http://www.marshallprotocol.com/view_topic.php?id=12517&forum_id=35&jump_to=199982#p199982
+https://www.marshallprotocol.com/view_topic.php?id=12517&forum_id=35&jump_to=199982#p199982
 (Gary does not report any ill health. He works an IT job and actively maintains his farm while on the MP.)
 Lab results (2010):
@@ Line 218: / Line 224: @@
 From CaptBubba's progress.
-http://www.marshallprotocol.com/view_topic.php?id=12474&forum_id=17&jump_to=198938#p198938
+https://www.marshallprotocol.com/view_topic.php?id=12474&forum_id=17&jump_to=198938#p198938
 (She posts in the medical professional's forum. She reports plans for taking a 10-day vacation with her husband to Alaska the week following these lab results.)
 Lab results (2010):
@@ Line 233: / Line 239: @@
 From Claire's progress (Her health condition remains stable.)
-http://marshallprotocol.com/view_topic.php?id=8979&forum_id=35&jump_to=186714#p186714
+https://marshallprotocol.com/view_topic.php?id=8979&forum_id=35&jump_to=186714#p186714
 Lab results:
                                Sept'09   Nov'09
@@ Line 243: / Line 249: @@
 From Freddie's progress. (He just turned 71 years old and reports continued improvements in health after 5+ years on MP.)
-http://www.marshallprotocol.com/view_topic.php?id=5422&forum_id=35&jump_to=200005#p200005
+https://www.marshallprotocol.com/view_topic.php?id=5422&forum_id=35&jump_to=200005#p200005
 Lab results:                              Mar'09   Jan'10   Aug'10
 BUN                             37       40       61      (ref 6-20) //highest was 106//
@@ Line 259: / Line 265: @@
 From: Dr Trevor Marshall
 Date: 2010-09-06 16:15:30
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=13865
+Reply: https://www.marshallprotocol.com/reply.php?topic_id=13865
-Verena, even though eGFR values frequently drop into the twenties, and occasionally into the teens, there has been no kidney failure. Nobody has needed dialysis, and it would be ludicrous for anybody to have been biopsied under these circumstances.
+Varia, even though eGFR values frequently drop into the twenties, and occasionally into the teens, there has been no kidney failure. Nobody has needed dialysis, and it would be ludicrous for anybody to have been biopsied under these circumstances.
 We have seen really high Creatinine, we should dig out these values and put them in the MPKB. I don't recall the values off the top of my head...
-http://mpkb.org/home/protocol/olmesartan/kidney_disease
+https://mpkb.org/home/protocol/olmesartan/kidney_disease
@@ Line 283: / Line 289: @@
-<blockquote>In certain cases, improved clinical outcomes are associated with elevated kidney metabolites. A recent Japanese four-year follow up study of 877 men found that lower serum creatinine was significantly associated with an increased risk of type 2 diabetes.(({{pubmed>long:19074997}}))
+<blockquote>In certain cases, improved clinical outcomes are associated with elevated kidney metabolites. A recent Japanese four-year follow up study of 877 men found that lower serum creatinine was significantly associated with an increased risk of type 2 diabetes.(({{pmid>long:19074997}}))
 </blockquote>
@@ Line 352: / Line 358: @@
 </blockquote>
-===== References =====
+===== References =====</nodisp>

home/tests/kidney.txt · Last modified: 09.14.2022 by 127.0.0.1