This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revision | |||
home:diseases:anorexia_bulimia [08.12.2019] – [Patient experiences] sallieq | home:diseases:anorexia_bulimia [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 4: | Line 4: | ||
Discussion in The Economist print edition 29 Sep 2005 | Discussion in The Economist print edition 29 Sep 2005 | ||
- | [[http:// | + | [[https:// |
===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | The intrinsic ability of bacteria to regulate their growth and to maintain their population within the gut suggests that gut bacteria can interfere with molecular pathways controlling energy balance in the host. (({{pubmed> | + | The intrinsic ability of bacteria to regulate their growth and to maintain their population within the gut suggests that gut bacteria can interfere with molecular pathways controlling energy balance in the host. (({{pmid> |
===== Immune overload ===== | ===== Immune overload ===== | ||
Line 21: | Line 21: | ||
An immune overload hypothesis would suggest that compensating withdrawal from some activities would help recovery from eating disorders, and certainly a reduction of unnecessary parental pressure may be needed. | An immune overload hypothesis would suggest that compensating withdrawal from some activities would help recovery from eating disorders, and certainly a reduction of unnecessary parental pressure may be needed. | ||
- | [[http:// | + | [[https:// |
< | < | ||
Line 89: | Line 89: | ||
===== Further Research | ===== Further Research | ||
- | We found significantly altered correlations between alpha-MSH autoAb levels and the total Eating Disorder Inventory-2 score, as well as most of its subscale dimensions in AN and BN patients vs. controls. Remarkably, these correlations were opposite in AN vs. BN patients. In contrast, levels of autoAbs reacting with adrenocorticotropic hormone, OT, or VP had only few altered correlations with the Eating Disorder Inventory-2 subscale dimensions in AN and BN patients. Thus, our data reveal that core psychobehavioral abnormalities characteristic for eating disorders correlate with the levels of autoAbs against alpha-MSH, suggesting that AN and BN may be associated with autoAb-mediated dysfunctions of primarily the melanocortin system. | + | We found significantly altered correlations between alpha-MSH autoAb levels and the total Eating Disorder Inventory-2 score, as well as most of its subscale dimensions in AN and BN patients vs. controls. Remarkably, these correlations were opposite in AN vs. BN patients. In contrast, levels of autoAbs reacting with adrenocorticotropic hormone, OT, or VP had only few altered correlations with the Eating Disorder Inventory-2 subscale dimensions in AN and BN patients. Thus, our data reveal that core psychobehavioral abnormalities characteristic for eating disorders correlate with the levels of autoAbs against alpha-MSH, suggesting that AN and BN may be associated with autoAb-mediated dysfunctions of primarily the melanocortin system. |
- | Hypovolemia-induced obesity and diabetes. (({{pubmed> | + | Hypovolemia-induced obesity and diabetes. (({{pmid> |
- | Imaging studies reveal[[http:// | + | Imaging studies reveal[[https:// |
- | [[http:// | + | [[https:// |
- | Famine may affect the microbiome in a lasting way(({{pubmed> | + | Famine may affect the microbiome in a lasting way(({{pmid> |
- | [[http:// | + | [[https:// |
- | in New Insights in Anorexia Nervosa (({{pubmed> | + | in New Insights in Anorexia Nervosa (({{pmid> |
P. Gorwood, J. Epelbaum and colleagues assemble seven possible models, each accompanied by illustrative figures. | P. Gorwood, J. Epelbaum and colleagues assemble seven possible models, each accompanied by illustrative figures. | ||
Line 109: | Line 109: | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
Line 175: | Line 176: | ||
* legacy content | * legacy content | ||
- | * [[http:// | + | * [[https:// |
(//Paul and/or Amy// ??) I'm not sure I can completely tease out the significance of this study, but this sort of result suggests that famine may affect the microbiome in a lasting way: | (//Paul and/or Amy// ??) I'm not sure I can completely tease out the significance of this study, but this sort of result suggests that famine may affect the microbiome in a lasting way: | ||
- | [[http:// | + | [[https:// |
Final point: IMO, we should all be careful not to define the chain of events. What if a disruption in the microbiome preceded anorexia and the anorexia " | Final point: IMO, we should all be careful not to define the chain of events. What if a disruption in the microbiome preceded anorexia and the anorexia " | ||
- | ===== References ===== | + | ===== References =====</ |