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--- home:diseases:depression [02.18.2019] – [Patient experience] sallieq
+++ home:diseases:depression [04.09.2020] – [Immune suppression] sallieq
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 [[https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.12198|Impact of microbiota on brain function]]
+There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced [[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222768#pone.0222768.ref012|risk of depression]].(({{pubmed>long:88888888}}))
 ===== Virtues of depression =====
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 In the research field of psychoneuroimmunology, accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. In this respect, there has been increasing interest in the putative involvement of the immune system in psychiatric disorders. Cytokines and major depression (({{pubmed>long:15694227}}))
+==== Immune suppression ====
+Two U.S. government reports from the 1970s to 1980s provide evidence for many neuropsychiatric effects of non-thermal microwave EMFs, based on occupational exposure studies.[[https://www.ncbi.nlm.nih.gov/pubmed/26300312|(EMFs) produce widespread neuropsychiatric effects including depression.]]
+In summary, then, the mechanism of action of microwave EMFs, the role of the VGCCs in the brain, the impact of non-thermal EMFs on the brain, extensive epidemiological studies performed over the past 50 years, and five criteria testing for causality, all collectively show that various non-thermal microwave EMF exposures produce diverse neuropsychiatric effects.
 ===== Immune signaling =====
 A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells (({{pubmed>long:16223770}}))
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 [[https://www.bbc.com/news/health-37166293|many don't respond to existing therapies and so some scientists are now exploring a new frontier - whether the immune system could be causing depression.]]
+[[http://www.jneuropsychiatry.org/peer-review/depression-and-inflammation-disentangling-a-clear-yet-complex-and-multifaceted-link.html|depression and inflammation seem closely connected. Specifically that patients with inflammatory diseases are more likely to have MDD,  a large number of people with major depression show inflammatory biomarkers, and patients treated with cytokines are at increased risk of developing depression. Also inflammatory mediators have been found to alter glutamate and monoamine neurotransmission, glucocorticoid receptor resistance and hippocampal neurogenesis. Also, inflammation is able to alter brain signalling patterns, to affect cognition.]]
+The 'cytokine hypothesis of depression' implies that proinflammatory cytokines, acting as neuromodulators, represent the key factor in the (central) mediation of the behavioural, neuroendocrine and neurochemical features of depressive disorders. This view is supported by various findings. Several medical illnesses, which are characterised by chronic inflammatory responses, e.g. rheumatoid arthritis, have been reported to be accompanied by depression. (({{pubmed>long:    15694227}}))

home/diseases/depression.txt · Last modified: 09.14.2022 by 127.0.0.1