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home:diseases:ibd [03.13.2019] – [Research] sallieqhome:diseases:ibd [03.21.2019] – [Research] sallieq
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 <blockquote> It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies.  <blockquote> It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies. 
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 Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa.  Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa. 
  
- Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly, the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation, contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment.</blockquote> + Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly, the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation, contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment. 
 +</blockquote>
  
 'Western'-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens).   (({{pubmed>long:26011307}}))  'Western'-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens).   (({{pubmed>long:26011307}})) 
  
-[[https://www.sciencemag.org/news/2018/11/do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]]+Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease.  [[https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.017541-0#tab2|microbiology research]] 
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 +Butyric acid in functional constipation   (({{pubmed>long:24868272}})) 
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 +Butyric acid in irritable bowel syndrome  (({{pubmed>long:24868283}}))
      
 +[[https://www.sciencemag.org/news/2018/11/do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these gut bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]]
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 +[[https://www.karger.com/Article/FullText/477386|Resistant Starch Regulates Gut Microbiota: Structure, 
 +Biochemistry and Cell Signalling]]
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 +[{{:home:diseases:file:table_1_yang_et_al.gif|**Table 1  Yang et al **}}]
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 =====  Patient interviews  ===== =====  Patient interviews  =====
home/diseases/ibd.txt · Last modified: 09.14.2022 by 127.0.0.1
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