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--- home:diseases:ibd [03.21.2019] – [Research] sallieq
+++ home:diseases:ibd [07.23.2019] – [Research] sallieq
@@ Line 133: / Line 133: @@
 [[http://www.newswise.com/articles/view/515982|Targeted Antibiotics Lead to Long-lasting Improvement in IBS Symptoms]]
+It is apparently very rare for a patient to actually be allergic to Olmesartan (see Research below). An alternative approach where there is present a confirmed mycobacterial infection was recorded here [[http://www.mattioli1885journals.com/index.php/sarcoidosis/article/view/6769/4736|MAP Abx]] .
@@ Line 180: / Line 182: @@
 "It is increasingly apparent that bacteria are playing a role in healthy development, and need to be properly managed by the mucosal immune system to avoid inflammatory diseases" Gewirtz explained. (({{pubmed>long:22863420}})) </blockquote>
-===== Research =====
+=====  Patient interviews  =====
-Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely.  (({{pubmed>long:25023670}}))
-In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.   (({{pubmed>long:25947920}}))
+<html>
+<div class="patientinterviews">
-Development, validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium.  (({{pubmed>long:25557335}}))
+<html>
+<div class="patientinterviewboxl">
+<div class="patientinterviewimage"></html>{{:home:patients:melinda.gif?nolink|}}<html></div>
+<div class="patientinterviewtext">
+<div class="patientinterviewname"></html>Melinda Stiles<html></div></html>
-<blockquote> It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies.
+Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis
+Read the [[http://bacteriality.com/2008/02/17/interview16/|interview]]
-Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa.
+<html></div></div>
- Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly, the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation, contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment.</blockquote>
+<br clear="left" />
-'Western'-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens).   (({{pubmed>long:26011307}}))
+</div>
+</html>
-Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease.  [[https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.017541-0#tab2|microbiology research]]
-Butyric acid in functional constipation   (({{pubmed>long:24868272}}))
+Interviews of patients with other diseases are [[home:patients:patient_interviews|also available]].
-Butyric acid in irritable bowel syndrome  (({{pubmed>long:24868283}}))
+{{tag>disease }}
-[[https://www.sciencemag.org/news/2018/11/do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these gut bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]]
+===== Research =====
-[[https://www.karger.com/Article/FullText/477386|Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling]]
+Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely.  (({{pubmed>long:25023670}}))
-[{{:home:diseases:file:table_1_yang_et_al.gif|**Table 1  Yang et al **}}]
+In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.   (({{pubmed>long:25947920}}))
-=====  Patient interviews  =====
+Development, validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium.  (({{pubmed>long:25557335}}))
-<html>
+<blockquote> It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies.
-<div class="patientinterviews">
-<html>
+Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa.
-<div class="patientinterviewboxl">
-<div class="patientinterviewimage"></html>{{:home:patients:melinda.gif?nolink|}}<html></div>
-<div class="patientinterviewtext">
-<div class="patientinterviewname"></html>Melinda Stiles<html></div></html>
-Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis
+ Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly, the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation, contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment.
+</blockquote>
-Read the [[http://bacteriality.com/2008/02/17/interview16/|interview]]
+'Western'-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens).   (({{pubmed>long:26011307}}))
-<html></div></div>
+Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease.  [[https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.017541-0#tab2|microbiology research]]
+Butyric acid in functional constipation   (({{pubmed>long:24868272}}))
-<br clear="left" />
+Butyric acid in irritable bowel syndrome  (({{pubmed>long:24868283}}))
+[[https://www.sciencemag.org/news/2018/11/do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these gut bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]]
-</div>
+[[https://www.karger.com/Article/FullText/477386|Resistant Starch Regulates Gut Microbiota: Structure,
-</html>
+Biochemistry and Cell Signalling]]
+immune mechanisms and interactions between cells of the immune system and tissue environment (({{pubmed>long:28126697}}))
-Interviews of patients with other diseases are [[home:patients:patient_interviews|also available]].
+[{{:home:diseases:file:table_1_yang_et_al.gif|**Table 1  Yang et al **}}]
-{{tag>disease }}

home/diseases/ibd.txt · Last modified: 09.14.2022 by 127.0.0.1