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Osteoarthritis

Introduction

Mayo clinic

Usefulness of broad-range PCR for the diagnosis of osteoarticular infections.1)

Evidence of infectious cause

Since studies are now showing that tetracycline can slow down the OA process, this suggests that this process is impacted by bacteria. I suspect that lost cartilage will not be replaced but that eliminating CWD bacteria might halt the degenerative process.

The almost universal use of methotrexate and the rapid development of potent biologic agents have eclipsed the potential usage of TETs for RA. Ironically, it is in osteoarthritis, where there has only been one clinical trial which essentially failed, that the best potential exists for use of an MMP-inhibiting TET. 2)

Accepted knowledge

This osteoarthritis (degenerative arthritis) website states:

Research scientists have found that doxycycline, a tetracycline drug, has been shown to slow the progression of cartilage degeneration in the knees of patients with osteoarthritis. This effect seems to be a result of the drug's effect on enzymes that destroy cartilage rather than on their properties as antibiotics. More studies are needed to determine the significance of this interesting work.

-Osteoarthritis (OA) is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints.

-Osteoarthritis occurs more frequently as we age. Primary osteoarthritis is mostly related to aging.

-Most cases of osteoarthritis have no known cause and are referred to as primary osteoarthritis.

-Osteoarthritis occasionally can be found in multiple members of the same family.

-Unlike many other forms of arthritis that are systemic illnesses, such as rheumatoid arthritis and systemic lupus, osteoarthritis does not affect other organs of the body.

-common x-ray findings of osteoarthritis include loss of joint cartilage, narrowing of the joint space between adjacent bones, and bone spur formation.

MP comment

I am having more and more difficulty accepting any disease or symptom are merely being part of the 'normal' aging process. How often do patients diagnosed with OA have undiagnosed systemic Th1 inflammationThe complex biological response of vascular tissues to harmful stimuli such as pathogens or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue.?

Management

Is aquatic exercise more effective than land-based exercise for knee osteoarthritis? 3)

Research

Why does hyaline cartilage fail to repair? 4)

a comprehensive review on recent literature describing signal pathways in the hypertrophy of MSCs-derived in vitroA technique of performing a given procedure in a controlled environment outside of a living organism - usually a laboratory. differentiated chondrocytes and chondrocytes, with an emphasis on the crosstalk between these pathways. 5)

Cytokines such as IL-1 and TNF-alphaA cytokine critical for effective immune surveillance and is required for proper proliferation and function of immune cells. produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression. Cytokines also blunt chondrocyte compensatory synthesis pathways required to restore the integrity of the degraded extrecellular matrix (ECM). Moreover, in OA synovium, a relative deficit in the production of natural antagonists of the IL-1 receptor (IL-1Ra) has been demonstrated, and could possibly be related to an excess production of nitric oxide in OA tissues. 6)

Altogether, our data show that tetracyclines have no inhibitory potential on any proteoglycanolytic activities within mild or moderately affected human OA cartilage at therapeutic achievable plasma levels. 7)

Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.

We detected CP in the plasma of healthy subjects and surprisingly found that CP was increased in both patients with eOA and eRA whereas anti-CCP antibodies were predominantly present in eRA. A 4-class diagnostic algorithm combining plasma/serum CP, anti-CCP antibody and hydroxyproline applied to a cohort gave specific and sensitive detection and discrimination of eOA, eRA, other non-RA inflammatory joint diseases and good skeletal health.8)

After adjusting for all the covariates, the relative odds (95% confidence interval) of developing definite knee OA per increment of 1 SD (20.7 ng/mL) in winter season 25(OH)D was 1.57 (1.10-2.27), whereas for summer season sera the corresponding rate was 0.53 (0.28-1.00). CONCLUSION: The results do not support the hypothesis that a low level of serum 25(OH)D contributes to the development of OA. 9)

Notes and comments

Somewhere I think I have seen the idea that microbes multipy with ease in damged tissu… if only i knew where (sigh) — Sallie Q 02.17.2019

broken link broken promise ?? The Promise of a Tetracycline Antibiotic for Treating Osteoarthritis An Antibiotic to Slow Osteoarthritis

<DiseaseHierarchy>

http://www.webmd.com/osteoarthritis/news/20101108/vitamin-d-fails-osteoarthritis-test?ecd=wnl_art_111910

References

1)
Usefulness of broad-range PCR for the diagnosis of osteoarticular infections.
Fenollar F, Lévy PY, Raoult D
Curr Opin Rheumatol20p463-70(2008 Jul)
3)
Is aquatic exercise more effective than land-based exercise for knee osteoarthritis?
Dong R, Wu Y, Xu S, Zhang L, Ying J, Jin H, Wang P, Xiao L, Tong P
Medicine (Baltimore)97pe13823(2018 Dec)
4)
Articular fibrocartilage - Why does hyaline cartilage fail to repair?
Armiento AR, Alini M, Stoddart MJ
Adv Drug Deliv Revp(2018 Dec 31)
5)
The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes.
Zhong L, Huang X, Karperien M, Post JN
Int J Mol Sci16p19225-47(2015 Aug 14)
6)
The role of cytokines in osteoarthritis pathophysiology.
Fernandes JC, Martel-Pelletier J, Pelletier JP
Biorheology39p237-46(2002)
8)
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.
Ahmed U, Anwar A, Savage RS, Costa ML, Mackay N, Filer A, Raza K, Watts RA, Winyard PG, Tarr J, Haigh RC, Thornalley PJ, Rabbani N
Sci Rep5p9259(2015 Mar 19)
9)
Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study.
Konstari S, Paananen M, Heliövaara M, Knekt P, Marniemi J, Impivaara O, Arokoski J, Karppinen J
Scand J Rheumatol41p124-31(2012 Mar)
home/diseases/osteoarthritis.txt · Last modified: 02.18.2019 by sallieq
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