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Scleroderma

Evidence of infectious cause

In the September 2009 edition of the Annals of the New York Academy of the Sciences, a study was published that had evaluated, “… the potential role infections may have on the pathogenesis of systemic scleroderma.” In this study, researchers studied serological samples taken from eighty patients of European origin with the disease (as compared to two-hundred and ninety-six healthy controls) to assess the presence of antibodies for a number of infectious agents, including, “… hepatitis B virus, hepatitis C virus, toxoplasmosis, rubella, CMV, EBV, and Treponema pallidum.” Data collected from the study revealed, “… that antibodies against CMV, HBV, and toxoplasmosis were detected more often in patients with SSc.“ Study authors concluded, “This association implies that infectious agents may have a role in disease pathogenesis and expression.”

Source:

http://www.ncbi.nlm.nih.gov/pubmed/19758208

A Guide to Antibiotic Therapy

Bacterial Infection as the Cause of Scleroderma:

by Dr. Alan Cantwell MD, Pat Ganger

This easy-read article (with pictures) is intended as an Internet guide to considering this disease for antibiotic therapy, and a review of supporting literature. Dr Cantwell's illuminating microscopic work and understanding of CWD pathogens occupies the first half of the article. Pat Ganger completes the article as she describes her use of The Road Back therapy in the mid 1980's and how it saved her life (A 1995 Canadian study by Abu-Shakra and Lee showed 61% of systemic scleroderma patients died within 9 years).

Pat Ganger continues to take minocycline today, 23 years later. (MPer's might see this as a complementary, but limited antibiotic therapy by today's MP standards, but also, there was no MP in 1985.)

Dr. Cantwell reported finding pleomorphic bacteria in the skin of scleroderma patients over 20 years ago. 1)

Member joanbpass: Scleroderma: Assessing my improvements

Recent research

Autologous Stem-Cell Transplantation for Severe Scleroderma.2)

Position Statement from the American Society for Blood and Marrow Transplantation 3)

Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival 4)

Notes and comments

broke Bacterial Infection as the Cause of Scleroderma: A Guide to Antibiotic Therapy by Dr. Alan Cantwell MD, Pat Ganger This easy-read article (with pictures) is intended as an Internet guide

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References

2)
Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.
Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE
N Engl J Med378p35-47(2018 Jan 4)
3)
Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation.
Sullivan KM, Majhail NS, Bredeson C, Carpenter PA, Chatterjee S, Crofford LJ, Georges GE, Nash RA, Pasquini MC, Sarantopoulos S, Storek J, Savani B, St Clair EW
Biol Blood Marrow Transplant24p1961-1964(2018 Oct)
4)
Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival in two independent clinical trial cohorts.
Volkmann ER, Tashkin DP, Sim M, Li N, Goldmuntz E, Keyes-Elstein L, Pinckney A, Furst DE, Clements PJ, Khanna D, Steen V, Schraufnagel DE, Arami S, Hsu V, Roth MD, Elashoff RM, Sullivan KM
Ann Rheum Disp(2018 Nov 8)
home/diseases/scleroderma.txt · Last modified: 12.05.2018 by sallieq
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