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home:diseases:scleroderma [02.07.2019] – [Notes and comments] sallieqhome:diseases:scleroderma [09.14.2022] (current) – external edit 127.0.0.1
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 Source: Source:
  
-http://www.ncbi.nlm.nih.gov/pubmed/19758208+https://www.ncbi.nlm.nih.gov/pubmed/19758208
 </blockquote> </blockquote>
  
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-Hypodermitis sclerodermiformis. Successful treatment with ultrasound.  (({{pubmed>long:7082022}}))  +Hypodermitis sclerodermiformis. Successful treatment with ultrasound.  (({{pmid>long:7082022}}))  
  
 ===== A Guide to Antibiotic Therapy ===== ===== A Guide to Antibiotic Therapy =====
- 
  
 Bacterial Infection as the Cause of Scleroderma: Bacterial Infection as the Cause of Scleroderma:
  
-by Dr. Alan Cantwell MD, Pat Ganger +Dr. Cantwell reported finding pleomorphic bacteria in the skin of scleroderma patients over 20 years ago. (({{pmid>long:6724767}}))
- +
-This easy-read article (with pictures) is intended as an Internet guide to considering this disease for antibiotic therapy, and a review of supporting literature. Dr Cantwell's illuminating microscopic work and understanding of CWD pathogens occupies the first half of the article. Pat Ganger completes the article as she describes her use of The Road Back therapy in the mid 1980's and how it saved her life (A 1995 Canadian study by Abu-Shakra and Lee showed 61% of systemic scleroderma patients died within 9 years). +
- +
-Pat Ganger continues to take minocycline today, 23 years later. (MPer's might see this as a complementary, but limited antibiotic therapy by today's MP standards, but also, there was no MP in 1985.) +
- +
-Dr. Cantwell reported finding pleomorphic bacteria in the skin of scleroderma patients over 20 years ago. (({{pubmed>long:6724767}}))+
  
 Member joanbpass: Scleroderma: Assessing my improvements Member joanbpass: Scleroderma: Assessing my improvements
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 ===== Recent research  ===== ===== Recent research  =====
  
-Assessment and management of patients with juvenile localised scleroderma (({{pubmed>long:30563543}}))  +Assessment and management of patients with juvenile localised scleroderma (({{pmid>long:30563543}}))  
  
-Autologous Stem-Cell Transplantation for Severe Scleroderma.(({{pubmed>long:29298160}})) +Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.  (({{pmid>long:30687318}}))
  
-Position Statement from the American Society for Blood and Marrow Transplantation (({{pubmed>long:29953945}})) +Autologous Stem-Cell Transplantation for Severe Scleroderma.(({{pmid>long:29298160}})) 
  
-Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival (({{pubmed>long:30409830}}))  +Position Statement from the American Society for Blood and Marrow Transplantation (({{pmid>long:29953945}})) 
  
-There are many factors to be taken under consideration with SSc onset, although a strong correlation has been established for only a few. The most distinct factors are: crystalline silica and organic solvents (such as white spirit, aromatic, aliphatic-chain, chlorinated solvents, ketones, welding fumes). For other factors, which include abstestos, air pollution, other chemicals, silicone breast implants, tobacco smoking, drug reactions, diet influence and exposure to heavy metals, the jury is still out, and their position in SSc onset needs further studies.  (({{pubmed>long:30586984}}))  +Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival (({{pmid>long:30409830}}))  
  
-Data suggest naltrexone could be helpful in the treatment of pruritus and a variety of inflammatory and acantholytic skin diseases refractory to other treatments. At higher doses, liver function tests should be monitored on a periodic basis.(({{pubmed>long:30582992}})) +There are many factors to be taken under consideration with SSc onset, although a strong correlation has been established for only a few. The most distinct factors are: crystalline silica and organic solvents (such as white spirit, aromatic, aliphatic-chain, chlorinated solvents, ketones, welding fumes). For other factors, which include abstestos, air pollution, other chemicals, silicone breast implants, tobacco smoking, drug reactions, diet influence and exposure to heavy metals, the jury is still out, and their position in SSc onset needs further studies.  (({{pmid>long:30586984}}))  
  
-Genetic overlap "we performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3477 systemic sclerosis (SSc), and 6670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET." (({{pubmed>long:30572963}}))  +Data suggest naltrexone could be helpful in the treatment of pruritus and a variety of inflammatory and acantholytic skin diseases refractory to other treatments. At higher doses, liver function tests should be monitored on a periodic basis.(({{pmid>long:30582992}})) 
  
-To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis.  A good correlation was observed between distinctive quantitative and qualitative NVC features with lung functional parameters such as FVC and DLCO. It is suggested that vasculopathy could play a role (({{pubmed>long:30567570}}))  +Genetic overlap "we performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3477 systemic sclerosis (SSc), and 6670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET." (({{pmid>long:30572963}}))  
  
-The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage.  (({{pubmed>long:30554308}}))  +To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis.  A good correlation was observed between distinctive quantitative and qualitative NVC features with lung functional parameters such as FVC and DLCO. It is suggested that vasculopathy could play a role (({{pmid>long:30567570}}))  
  
-Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma patterns ('early', 'active' and 'late') with future severe clinical involvement in a systemic sclerosis (SSc) population. (({{pubmed>long:22402146}}))  +The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage.  (({{pmid>long:30554308}}))  
  
-This capillaroscopic score may represent a feasible and simple tool in SSc patients' assessment. The routinely use of this parameter might permit to recognize and to preventively treat SSc patients at high risk to develop digital ulcers.  (({{pubmed>long:18854881}}))  +Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma patterns ('early', 'active' and 'late') with future severe clinical involvement in a systemic sclerosis (SSc) population. (({{pmid>long:22402146}}))   
 + 
 +This capillaroscopic score may represent a feasible and simple tool in SSc patients' assessment. The routinely use of this parameter might permit to recognize and to preventively treat SSc patients at high risk to develop digital ulcers.  (({{pmid>long:18854881}}))  
  
 ===== Interview ===== ===== Interview =====
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 scleroderma scleroderma
  
-Read the [[http://bacteriality.com/2007/09/cantwell/|interview]]+Read the [[https://bacteriality.com/2007/09/cantwell/|interview]]
  
 <html></div></div> <html></div></div>
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 //Prof M// Scleroderma is a Th1 disease. It is suspected to be due to inappropriate activity of the collagen oligomeric matrix protein (COMP) during the formation of the skin. COMP is a protein which relies upon Vitamin D, at least in part, for its stability. You might even see improvement when you cut your daughter's 25-D down to more reasonable levels, but I don't want to raise your hopes too much just yet:) Scleroderma is unlikely to to go away overnight:) //Prof M// Scleroderma is a Th1 disease. It is suspected to be due to inappropriate activity of the collagen oligomeric matrix protein (COMP) during the formation of the skin. COMP is a protein which relies upon Vitamin D, at least in part, for its stability. You might even see improvement when you cut your daughter's 25-D down to more reasonable levels, but I don't want to raise your hopes too much just yet:) Scleroderma is unlikely to to go away overnight:)
  
-Dr Alan Cantwell spent a lot of his professional life looking at the links between Th1 bacteria and Scleroderma. You will find one of his papers on the subject at http://www.JOIMR.org (search for 'scleroderma' on that page)+Dr Alan Cantwell spent a lot of his professional life looking at the links between Th1 bacteria and Scleroderma. You will find one of his papers on the subject at https://www.JOIMR.org (search for 'scleroderma' on that page)
  
  
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 broken link removed broken link removed
-[[http://www.joimr.org/phorum/read.php?f=2&i=109&t=109|Bacterial Infection as the Cause of Scleroderma:+[[https://www.joimr.org/phorum/read.php?f=2&i=109&t=109|Bacterial Infection as the Cause of Scleroderma:
 A Guide to Antibiotic Therapy]] A Guide to Antibiotic Therapy]]
 by Dr. Alan Cantwell MD, Pat Ganger by Dr. Alan Cantwell MD, Pat Ganger
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   * legacy content   * legacy content
-  * http://www.marshallprotocol.com/view_topic.php?id=2697&forum_id=37&jump_to=54780#p54780 e247+  * https://www.marshallprotocol.com/view_topic.php?id=2697&forum_id=37&jump_to=54780#p54780 e247 
  
  
 +===== References =====</nodisp>
  
-===== References ===== 
home/diseases/scleroderma.txt · Last modified: 09.14.2022 by 127.0.0.1
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