Aging and Olmesartan

Some of the documented protective effects of ARBs

include the ability to:

  • decrease the incidence and progression of Alzheimer's disease and dementia1)
  • prevent migraines2)
  • inhibit liver fibrosis and aid liver healing3)
  • reduce insulin resistance in rats4)
  • 6 mg/kg olmesartan reduces the inflammatory process and bone loss in rats5)
  • protect the mitochondria from age-associated damage from oxidation6)
  • play a protective role against proliferative diabetic retinopathy 7)
  • reduce liver fibrosis8)
  • treatment of anxiety and stress-related disorders9)
  • reduce oxidative damage10) and limit aging 11) 12)

Olmesartan and other ARBs have been used

to block various bad effects of Angiotensin II, including heart failure. In this regard, olmesartan has been shown to:


80mg single dose vs 6hrlydosing
4 hourly compared to 6 hourly dosing

In August 2002, Trevor Marshall and Frances Marshall published a NetPrint about valsartan (Diovan), in which they reported that the once daily dosing of the ARBA drug which is an angiotensin receptor blocker. One of the ARBs is olmesartan (Benicar). Not all ARBs activate the Vitamin D Receptor. caused psychedelic dreams and psychotic events in two sarcoidosis patients. On the theory that these symptoms were caused by changes in plasma concentration, the frequency of the dosing of ARB was increased, which ended up reducing symptoms of disease including psychedelic dreams. This early insight into ARBs anti-inflammatory effects led Marshall to conclude that for an ARB to provide symptomatic relief, it was necessary to use more frequent dosing than typical. Professor Marshall would later go on to recommend frequent dosing of another ARB, olmesartan.

In rats, Olmesartan at 6 mg/kg optimally reduced the inflammatory process and bone loss22). That would be 9-10 tablets of Olmetec daily for a 64 Kg human

Olmesartan has also been shown to

  • prevent or delay left ventricular remodeling and hypertrophy in patients with type 2 diabetes 23)
  • reduce the volume of atherosclerotic plaques24) 25)
  • mildly reduce the risk of stroke in people at high risk for strokes (cerebrovascular events).26)
  • significantly remodel and destiffen the arterial wall material during long-term treatment 27)

A number of studies have found

that olmesartan and other ARBs possess various ways of protecting the kidneys from the effects of inflammation and cytokineAny of various protein molecules secreted by cells of the immune system that serve to regulate the immune system. damage:

  • in circadian rhythms between HR and MAP in CKD: Synchronization between the two rhythms was progressively lost as renal function deteriorated, and Olmesartan partly restored the synchronization 28)
  • in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition 29)
  • results suggest olmesartan can help decrease plasma AGE levels in patients on HD 30)
  • renal protective effects of olmesartan may be better than those of other ARBs 31)
  • olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects 32)

Recent studies showed

  • treatment with olmesartan inhibited bone loss 33)
  • olmesartan protects endothelial cells against oxidative stress-mediated cellular injury 34)
  • decreases viability of malignant cell lines35)
  • carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced the volume of larger atherosclerotic plaques 36)
  • improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan 37)
  • improvement of glycemic control & insulin resistance was only observed in olmesartan group 38)
  • OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes 39)
  • prevention of microalbuminuria in patients with type 2 diabetes and hypertension 40)

Long term treatment

Data suggest 40 & 80 mg olmesartan are able to significantly remodel & destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg. hyper.ahajournals.org/content/early/2014/07/07/HYPERTENSIONAHA.114.03282.reprint 41)

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