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home:food:aim_health:aging [04.10.2020] – [Dosage] sallieq | home:food:aim_health:aging [09.14.2022] (current) – external edit 127.0.0.1 | ||
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===== with additional studies ===== | ===== with additional studies ===== | ||
- | Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. | + | Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. |
- | | + | |
- | The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease. (({{pubmed> | + | The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease. (({{pmid> |
- | | + | |
- | Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. | + | Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. |
- | Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pubmed> | + | Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pmid> |
- | Administration of olmesartan suppressed the accumulation of macrophages in brachiocephalic atherosclerotic plaque. (in mice) (({{pubmed> | + | Administration of olmesartan suppressed the accumulation of macrophages in brachiocephalic atherosclerotic plaque. (in mice) (({{pmid> |
- | Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (**3 mg/kg**) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat) (({{pubmed> | + | Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (**3 mg/kg**) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat) (({{pmid> |
- | Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats. (({{pubmed> | + | Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats. (({{pmid> |
- | Replacing candesartan with olmesartan decreased LVMI in association with a sustained decrease of plasma Ang II over a 12-month period without changing blood pressure or plasma aldosterone in patients with essential hypertension. (({{pubmed> | + | Replacing candesartan with olmesartan decreased LVMI in association with a sustained decrease of plasma Ang II over a 12-month period without changing blood pressure or plasma aldosterone in patients with essential hypertension. (({{pmid> |
- | Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation. (({{pubmed> | + | Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation. (({{pmid> |
- | Therapeutic and supratherapeutic OLM doses had no clinically significant effect on cardiac repolarization and were well tolerated. (({{pubmed> | + | Therapeutic and supratherapeutic OLM doses had no clinically significant effect on cardiac repolarization and were well tolerated. (({{pmid> |
- | In conclusion, there is no robust signal for harm with olmesartan use. (({{pubmed> | + | In conclusion, there is no robust signal for harm with olmesartan use. (({{pmid> |
==== General research on aging ==== | ==== General research on aging ==== | ||
- | Holistic vitamin D supplementation with or without calcium is unlikely to be an effective primary prevention strategy for falls or fracture. There has also been high-quality evidence that vitamin D, daily or as a bolus, does not reduce the risk of cardiovascular events. (({{pubmed> | + | Holistic vitamin D supplementation with or without calcium is unlikely to be an effective primary prevention strategy for falls or fracture. There has also been high-quality evidence that vitamin D, daily or as a bolus, does not reduce the risk of cardiovascular events. (({{pmid> |
- | When using off-label Olmesartan, patients are observed to need fewer other pharmaceutical preparations to maintain and improve health status. | + | When using off-label Olmesartan, patients are observed to need fewer other pharmaceutical preparations to maintain and improve health status. |
==== Some of the documented protective effects of ARBs ==== | ==== Some of the documented protective effects of ARBs ==== | ||
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- | * decrease the incidence and progression of Alzheimer' | + | * decrease the incidence and progression of Alzheimer' |
- | * prevent migraines(({{pubmed> | + | * prevent migraines(({{pmid> |
- | * inhibit liver fibrosis and aid liver healing(({{pubmed> | + | * inhibit liver fibrosis and aid liver healing(({{pmid> |
- | * reduce insulin resistance in rats(({{pubmed> | + | * reduce insulin resistance in rats(({{pmid> |
- | * **6 mg/kg** olmesartan reduces the inflammatory process and bone loss in rats(({{pubmed> | + | * **6 mg/kg** olmesartan reduces the inflammatory process and bone loss in rats(({{pmid> |
- | * protect | + | * protect mitochondria from age-associated damage from oxidation(({{pmid> |
- | * play a protective role against proliferative diabetic retinopathy (({{pubmed> | + | * play a protective role against proliferative diabetic retinopathy (({{pmid> |
- | * reduce liver fibrosis(({{pubmed> | + | * reduce liver fibrosis(({{pmid> |
- | * treatment of anxiety and stress-related disorders(({{pubmed> | + | * treatment of anxiety and stress-related disorders(({{pmid> |
- | * reduce oxidative damage(({{pubmed> | + | * reduce oxidative damage(({{pmid> |
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to block various bad effects of Angiotensin II, including heart failure. In this regard, olmesartan has been shown to: | to block various bad effects of Angiotensin II, including heart failure. In this regard, olmesartan has been shown to: | ||
- | * protect the heart from damage from inflammation in myocarditis(({{pubmed> | + | * protect the heart from damage from inflammation in myocarditis(({{pmid> |
- | * ameliorate acute experimental autoimmune myocarditis, | + | * ameliorate acute experimental autoimmune myocarditis, |
- | * prevent acute left ventricular dysfunction(({{pubmed> | + | * prevent acute left ventricular dysfunction(({{pmid> |
- | * lower C-reactive protein, one of the acute phase proteins that increase during systemic inflammation(({{pubmed> | + | * lower C-reactive protein, one of the acute phase proteins that increase during systemic inflammation(({{pmid> |
- | * act as an antiarrhythmic(({{pubmed> | + | * act as an antiarrhythmic(({{pmid> |
- | * block the production of Angiotensin II, thus improving mortality rates in heart failure patients(({{pubmed> | + | * block the production of Angiotensin II, thus improving mortality rates in heart failure patients(({{pmid> |
- | * This study demonstrated that olmesartan reduced angiotensin II and aldosterone levels more effectively than azilsartan, resulting in a stable antihypertensive effect. Olmesartan also had an inhibitory effect on cardiac hypertrophy. Accordingly, | + | * This study demonstrated that olmesartan reduced angiotensin II and aldosterone levels more effectively than azilsartan, resulting in a stable antihypertensive effect. Olmesartan also had an inhibitory effect on cardiac hypertrophy. Accordingly, |
- | * Conclusion: In the present study, left ventricular hypertrophy and on arterial compliance were inhibited by a decrease in angiotensin II and aldosterone due to the change-over to olmesartan. In the future, protective effects on organs will be clarified by long-term observations. | + | * Conclusion: In the present study, left ventricular hypertrophy and on arterial compliance were inhibited by a decrease in angiotensin II and aldosterone due to the change-over to olmesartan. In the future, protective effects on organs will be clarified by long-term observations. |
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In August 2002, Trevor Marshall and Frances | In August 2002, Trevor Marshall and Frances | ||
- | In rats, Olmesartan at 6 mg/kg optimally reduced the inflammatory process and bone loss(({{pubmed> | + | In rats, Olmesartan at 6 mg/kg optimally reduced the inflammatory process and bone loss(({{pmid> |
For those with gastric issues, it is recommended that the pill be crushed and mixed with applesauce or similar to reduce impact on gastric lining. | For those with gastric issues, it is recommended that the pill be crushed and mixed with applesauce or similar to reduce impact on gastric lining. | ||
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=== Olmesartan has also been shown to === | === Olmesartan has also been shown to === | ||
- | * prevent or delay left ventricular remodeling and hypertrophy in patients with type 2 diabetes | + | * prevent or delay left ventricular remodeling and hypertrophy in patients with type 2 diabetes |
- | * reduce the volume of atherosclerotic plaques(({{pubmed> | + | * reduce the volume of atherosclerotic plaques(({{pmid> |
- | * mildly reduce the risk of stroke in people at high risk for strokes (cerebrovascular events).(({{pubmed> | + | * mildly reduce the risk of stroke in people at high risk for strokes (cerebrovascular events).(({{pmid> |
- | * significantly remodel and destiffen the arterial wall material during long-term treatment (({{pubmed> | + | * significantly remodel and destiffen the arterial wall material during long-term treatment (({{pmid> |
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that olmesartan possesses various ways of protecting the kidneys from the effects of inflammation and cytokine damage: | that olmesartan possesses various ways of protecting the kidneys from the effects of inflammation and cytokine damage: | ||
- | * in circadian rhythms between HR and MAP in CKD: Synchronization between the two rhythms was progressively lost as renal function deteriorated, | + | * in circadian rhythms between HR and MAP in CKD: Synchronization between the two rhythms was progressively lost as renal function deteriorated, |
- | * in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pubmed> | + | * in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pmid> |
- | * results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pubmed> | + | * results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pmid> |
- | * renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed> | + | * renal protective effects of olmesartan may be better than those of other ARBs (({{pmid> |
- | * olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects | + | * olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects |
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- | * treatment with olmesartan inhibited bone loss (({{pubmed> | + | * treatment with olmesartan inhibited bone loss (({{pmid> |
- | * olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pubmed> | + | * olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pmid> |
- | * decreases viability of malignant cell lines(({{pubmed> | + | * decreases viability of malignant cell lines(({{pmid> |
- | * carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced the volume of larger atherosclerotic plaques | + | * carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced the volume of larger atherosclerotic plaques |
- | * improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pubmed> | + | * improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pmid> |
- | * improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pubmed> | + | * improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pmid> |
- | * OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes | + | * OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes |
- | * prevention of microalbuminuria in patients with type 2 diabetes and hypertension | + | * prevention of microalbuminuria in patients with type 2 diabetes and hypertension |
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{{tag> | {{tag> | ||