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home:food:folic [01.12.2019] – [Excess folic acid can allow bacteria to proliferate] sallieq | home:food:folic [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | Folate naturally in foods is [[http:// | + | Folate naturally in foods is [[https:// |
* 1 µg of dietary folate equivalent = 0.6 µg of folic acid from fortified food, or | * 1 µg of dietary folate equivalent = 0.6 µg of folic acid from fortified food, or | ||
* 1 µg of food folate = 0.5 µg of a supplement taken on an empty stomach | * 1 µg of food folate = 0.5 µg of a supplement taken on an empty stomach | ||
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Folic acid is converted by the body into DHFR (DiHydro-Folate Reductase), which can be used by parasitic bacteria to form the nucleic acids, which are at the basis of their survival and reproductive cycles. | Folic acid is converted by the body into DHFR (DiHydro-Folate Reductase), which can be used by parasitic bacteria to form the nucleic acids, which are at the basis of their survival and reproductive cycles. | ||
- | So important is folic acid to the growth of bacteria that many therapies for infections slow disease progress by blocking activity of folic acid. A conventional treatment for sarcoidosis confirms that folic acid does indeed affect the activity of L-form bacteria. Some patients with sarcoidosis are prescribed [[http:// | + | So important is folic acid to the growth of bacteria that many therapies for infections slow disease progress by blocking activity of folic acid. A conventional treatment for sarcoidosis confirms that folic acid does indeed affect the activity of L-form bacteria. Some patients with sarcoidosis are prescribed [[https:// |
< | < | ||
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===== Clinical evidence ===== | ===== Clinical evidence ===== | ||
- | A 2009 combined analysis and extended follow-up of participants from two randomized, double-blind, | + | A 2009 combined analysis and extended follow-up of participants from two randomized, double-blind, |
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fortification (1992–1996) and after (2001–2004) — and found a significant | fortification (1992–1996) and after (2001–2004) — and found a significant | ||
increase in reported cases of colon cancer. The increase was 162% in people | increase in reported cases of colon cancer. The increase was 162% in people | ||
- | 45 to 64 years and 190% in people 65 to 79 years.(({{pubmed> | + | 45 to 64 years and 190% in people 65 to 79 years.(({{pmid> |
A pair of commentaries appearing in the November 2007 issue of //Nutrition Reviews// argue that folic acid benefits some and harms others. | A pair of commentaries appearing in the November 2007 issue of //Nutrition Reviews// argue that folic acid benefits some and harms others. | ||
- | Dr. Solomons, author of one of the review commentaries, | + | Dr. Solomons, author of one of the review commentaries, |
- | Dr. Young-In Kim authored the second commentary: “Folic Acid Fortification and Supplementation—Good for Some but Not So Good for Others.”(({{pubmed> | + | Dr. Young-In Kim authored the second commentary: “Folic Acid Fortification and Supplementation—Good for Some but Not So Good for Others.”(({{pmid> |
- | A 2010 study by House //et al.// has shown substantial adverse outcomes associated with high-dose B vitamins in patients with advanced diabetic nephropathy.(({{pubmed> | + | A 2010 study by House //et al.// has shown substantial adverse outcomes associated with high-dose B vitamins in patients with advanced diabetic nephropathy.(({{pmid> |
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===== Read more ===== | ===== Read more ===== | ||
- | * [[http:// | + | * [[https:// |
- | * [[http:// | + | * [[https:// |
{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | was broke [[http:// | + | was broke [[https:// |
* Legacy content | * Legacy content | ||
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
* | * | ||
- | [[http:// | + | [[https:// |
+ | |||
+ | ===== References =====</ | ||
- | ===== References ===== |