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home:food:folic [01.12.2019] – [Excess folic acid can allow bacteria to proliferate] sallieqhome:food:folic [09.14.2022] (current) – external edit 127.0.0.1
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-Folate naturally in foods is [[http://books.nap.edu/openbook.php?isbn=0309065542&page=196#pagetop|not bio-equivalent]] to synthetic sources. The equivalency is as follows (ug = microgram):+Folate naturally in foods is [[https://books.nap.edu/openbook.php?isbn=0309065542&page=196#pagetop|not bio-equivalent]] to synthetic sources. The equivalency is as follows (ug = microgram):
   * 1 µg of dietary folate equivalent = 0.6 µg of folic acid from fortified food, or   * 1 µg of dietary folate equivalent = 0.6 µg of folic acid from fortified food, or
   * 1 µg of food folate = 0.5 µg of a supplement taken on an empty stomach   * 1 µg of food folate = 0.5 µg of a supplement taken on an empty stomach
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 Folic acid is converted by the body into DHFR (DiHydro-Folate Reductase), which can be used by parasitic bacteria to form the nucleic acids, which are at the basis of their survival and reproductive cycles. Folic acid is converted by the body into DHFR (DiHydro-Folate Reductase), which can be used by parasitic bacteria to form the nucleic acids, which are at the basis of their survival and reproductive cycles.
  
-So important is folic acid to the growth of bacteria that many therapies for infections slow disease progress by blocking activity of folic acid. A conventional treatment for sarcoidosis confirms that folic acid does indeed affect the activity of L-form bacteria. Some patients with sarcoidosis are prescribed [[http://en.wikipedia.org/wiki/Methotrexate|methotrexate (MTX)]], a drug that temporarily slows progression of the disease by blocking the activity of folic acid and subsequently the activity of DHFR. Another drug that blocks the activity of DHFR is the antibiotic Trimethoprim, which is used to create the drug Bactrim. The antibiotic Bactrim was formerly used as part of the Marshall Protocol.+So important is folic acid to the growth of bacteria that many therapies for infections slow disease progress by blocking activity of folic acid. A conventional treatment for sarcoidosis confirms that folic acid does indeed affect the activity of L-form bacteria. Some patients with sarcoidosis are prescribed [[https://en.wikipedia.org/wiki/Methotrexate|methotrexate (MTX)]], a drug that temporarily slows progression of the disease by blocking the activity of folic acid and subsequently the activity of DHFR. Another drug that blocks the activity of DHFR is the antibiotic Trimethoprim, which is used to create the drug Bactrim. The antibiotic Bactrim was formerly used as part of the Marshall Protocol.
  
 <blockquote>It is commonly accepted that bacteria synthesize all their DiHydro-Folate directly and do not require folic acid in order to generate the nucleic acids (for DNA and RNA and protein transcription). <blockquote>It is commonly accepted that bacteria synthesize all their DiHydro-Folate directly and do not require folic acid in order to generate the nucleic acids (for DNA and RNA and protein transcription).
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 ===== Clinical evidence ===== ===== Clinical evidence =====
  
-A 2009 combined analysis and extended follow-up of participants from two randomized, double-blind, placebo-controlled clinical trials found that treatment with folic acid plus vitamin B(12) was associated with increased cancer outcomes and all-cause mortality in patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods.(({{pubmed>long:19920236}}))+A 2009 combined analysis and extended follow-up of participants from two randomized, double-blind, placebo-controlled clinical trials found that treatment with folic acid plus vitamin B(12) was associated with increased cancer outcomes and all-cause mortality in patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods.(({{pmid>long:19920236}}))
  
  
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 fortification (1992–1996) and after (2001–2004) — and found a significant fortification (1992–1996) and after (2001–2004) — and found a significant
 increase in reported cases of colon cancer. The increase was 162% in people increase in reported cases of colon cancer. The increase was 162% in people
-45 to 64 years and 190% in people 65 to 79 years.(({{pubmed>long:19190501}}))+45 to 64 years and 190% in people 65 to 79 years.(({{pmid>long:19190501}}))
  
 A pair of commentaries appearing in the November 2007 issue of //Nutrition Reviews// argue that folic acid benefits some and harms others. A pair of commentaries appearing in the November 2007 issue of //Nutrition Reviews// argue that folic acid benefits some and harms others.
  
-Dr. Solomons, author of one of the review commentaries, “Food Fortification with Folic Acid: Has the Other Shoe Dropped?”(({{pubmed>long:18038944}})) advises that a careful reconsideration of the fortification program is needed. “One size of dietary folic acid exposure does not fit all. It can be beneficial to some and detrimental to others at the same time,” writes Solomons.+Dr. Solomons, author of one of the review commentaries, “Food Fortification with Folic Acid: Has the Other Shoe Dropped?”(({{pmid>long:18038944}})) advises that a careful reconsideration of the fortification program is needed. “One size of dietary folic acid exposure does not fit all. It can be beneficial to some and detrimental to others at the same time,” writes Solomons.
  
-Dr. Young-In Kim authored the second commentary: “Folic Acid Fortification and Supplementation—Good for Some but Not So Good for Others.”(({{pubmed>long:18038943}})) According to Kim, exposure to high intakes of folic acid in early life and young adulthood may provide life-long protection from the tendency for cancer formation in different organs, such as the large intestines, whereas such exposures later in life, when cell damage has occurred, can spur on the advance of the tumor.+Dr. Young-In Kim authored the second commentary: “Folic Acid Fortification and Supplementation—Good for Some but Not So Good for Others.”(({{pmid>long:18038943}})) According to Kim, exposure to high intakes of folic acid in early life and young adulthood may provide life-long protection from the tendency for cancer formation in different organs, such as the large intestines, whereas such exposures later in life, when cell damage has occurred, can spur on the advance of the tumor.
  
-A 2010 study by House //et al.// has shown substantial adverse outcomes associated with high-dose B vitamins in patients with advanced diabetic nephropathy.(({{pubmed>long:20424250}})) These side effects included myocardial infarction, stroke, revascularization, and all-cause mortality. According to [[http://www.medscape.com/viewarticle/731177|one commentator]], unless other explanations come to light in further analyses of the study, these findings make repetition of a similar trial in this high-risk patient group unethical.+A 2010 study by House //et al.// has shown substantial adverse outcomes associated with high-dose B vitamins in patients with advanced diabetic nephropathy.(({{pmid>long:20424250}})) These side effects included myocardial infarction, stroke, revascularization, and all-cause mortality. According to [[https://www.medscape.com/viewarticle/731177|one commentator]], unless other explanations come to light in further analyses of the study, these findings make repetition of a similar trial in this high-risk patient group unethical.
  
  
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 ===== Read more ===== ===== Read more =====
  
-  * [[http://www.medscape.com/viewarticle/591111|Folic-Acid Fortification of Flour and Increased Rates of Colon Cancer]] +  * [[https://www.medscape.com/viewarticle/591111|Folic-Acid Fortification of Flour and Increased Rates of Colon Cancer]] 
-  * [[http://www.medscape.com/viewarticle/712591|Folate Supplementation Linked to Increased Cancer Incidence and Mortality]]+  * [[https://www.medscape.com/viewarticle/712591|Folate Supplementation Linked to Increased Cancer Incidence and Mortality]]
  
    
 {{tag>Food_and_drink supplements foods_to_avoid foods}} {{tag>Food_and_drink supplements foods_to_avoid foods}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
-was broke   [[http://pathmicro.med.sc.edu/mayer/antibiot.htm|activity of folic acid]]+was broke   [[https://pathmicro.med.sc.edu/mayer/antibiot.htm|activity of folic acid]]
  
   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum2/2434.html#p21787 e184  +    * https://www.marshallprotocol.com/forum2/2434.html#p21787 e184  
-    * http://www.marshallprotocol.com/view_topic.php?id=4062&forum_id=2&jump_to=36062#p36062 e252+    * https://www.marshallprotocol.com/view_topic.php?id=4062&forum_id=2&jump_to=36062#p36062 e252
     *      * 
  
  
-[[http://www.medscape.com/viewarticle/717934|High Plasma Folate Levels in Pregnancy May Increase Asthma Risk for Offspring]]+[[https://www.medscape.com/viewarticle/717934|High Plasma Folate Levels in Pregnancy May Increase Asthma Risk for Offspring]] 
 + 
 +===== References =====</nodisp>
  
-===== References ===== 
home/food/folic.1547258218.txt.gz · Last modified: by sallieq
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