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home:lifestyle:light:photosensitivity [01.11.2019] – [Resolution of photosensitivity] sallieq | home:lifestyle:light:photosensitivity [09.01.2019] – [Neurological symptoms] sallieq | ||
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======Photosensitivity====== | ======Photosensitivity====== | ||
- | Abnormal sensitivity to sunlight and bright lights is known as photosensitivity and sometimes referred to as "sun flare" or photophobia. In the context of the MP, the ultimate cause of photosensitivity is the Th1 inflammatory disease process – [[home: | + | Abnormal sensitivity to sunlight and bright lights is known as photosensitivity and sometimes referred to as "sun flare" or photophobia. In the context of the MP, the ultimate cause of photosensitivity is the Th1 inflammatory disease process – [[home: |
Photosensitivity can occur either when the skin is exposed to bright natural light or the eyes are exposed to either natural or artificial light. Photosensitivity symptoms can occur immediately after exposure or begin 1 to 3 days later, sometimes persisting 5 days or more. | Photosensitivity can occur either when the skin is exposed to bright natural light or the eyes are exposed to either natural or artificial light. Photosensitivity symptoms can occur immediately after exposure or begin 1 to 3 days later, sometimes persisting 5 days or more. | ||
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==== Neurological symptoms ==== | ==== Neurological symptoms ==== | ||
- | The optic nerve directly connects each eye to the brain, possibly the body's most sensitive organ. Thus, light is transmitted to the brain via the eyes. Coursing through the portion of the brain known as the amygdala are nerves connecting it to a number of important brain centers, including the neocortex and visual cortex. Many types of angiotensin receptors are known to be active in the brain. This can have the profound effect of stimulating portions of the brain to cause significant neurological symptoms. | + | The optic nerve directly connects each eye to the brain, possibly the body's most sensitive organ. Thus light is transmitted to the brain via the eyes. Coursing through the portion of the brain known as the amygdala are nerves connecting it to a number of important brain centers, including the neocortex and visual cortex. Many types of angiotensin receptors are known to be active in the brain. This can have the profound effect of stimulating portions of the brain to cause significant neurological symptoms. |
This stimulation of the brain causes many of the neurological symptoms that are so bothersome to individuals with Th1 inflammation. Neurological symptoms include fatigue, irritability, | This stimulation of the brain causes many of the neurological symptoms that are so bothersome to individuals with Th1 inflammation. Neurological symptoms include fatigue, irritability, | ||
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===== Immunopathology or photosensitivity symptoms? ===== | ===== Immunopathology or photosensitivity symptoms? ===== | ||
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+ | This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, | ||