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home:lifestyle:light:photosensitivity [01.11.2019] – [Resolution of photosensitivity] sallieqhome:lifestyle:light:photosensitivity [09.14.2022] (current) – external edit 127.0.0.1
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 ======Photosensitivity====== ======Photosensitivity======
  
-Abnormal sensitivity to sunlight and bright lights is known as photosensitivity and sometimes referred to as "sun flare" or photophobia. In the context of the MP, the ultimate cause of photosensitivity is the Th1 inflammatory disease process –  [[home:mp:immunopathology#necessity_of_immunopathology|not the treatment itself]]. Exposure to natural or bright artificial light in a photosensitive person can lead to flares of internal disease activity, including exacerbation of any inflammatory disease symptoms. +Abnormal sensitivity to sunlight and bright lights is known as photosensitivity and sometimes referred to as "sun flare" or photophobia. In the context of the MP, the ultimate cause of photosensitivity is the Th1 inflammatory disease process –  [[home:mp:immunopathology#necessity_of_immunopathology|not the treatment itself]]. Exposure to natural or bright artificial light in a photosensitive person can lead to flares of internal disease activity, including exacerbation of any inflammatory disease symptoms. Neurological phenomena also occur since the amygdala has nerves connecting it to a number of important brain centers, including the neocortex and visual cortex. 
  
 Photosensitivity can occur either when the skin is exposed to bright natural light or the eyes are exposed to either natural or artificial light. Photosensitivity symptoms can occur immediately after exposure or begin 1 to 3 days later, sometimes persisting 5 days or more.  Photosensitivity can occur either when the skin is exposed to bright natural light or the eyes are exposed to either natural or artificial light. Photosensitivity symptoms can occur immediately after exposure or begin 1 to 3 days later, sometimes persisting 5 days or more. 
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-Even though the exact mechanisms by which Th1 disease leads to photosensitivity remains clouded, photosensitivity is well associated with Th1 disease. Examples of photoaggravated diseases include lupus erythematosus, erythema multiforme, atopic eczema, psoriasis, viral exanthemata, pemphigus, dermatitis herpetiformis, rosacea, and multiple sclerosis.(({{pubmed>long:11744394}})) (({{pubmed>long:17893968}})) (({{pubmed>long:19906495}}))  Even so, the variety of [[home:diseases|MP treatable illnesses]] for which there is a photosensitivity component and the severity of the photosensitivity reaction is widely underestimated by the majority of clinicians and researchers. This may be due to the time window for an adverse reaction, which is often hours or days after light exposure.+Even though the exact mechanisms by which Th1 disease leads to photosensitivity remains clouded, photosensitivity is well associated with Th1 disease. Examples of photoaggravated diseases include lupus erythematosus, erythema multiforme, atopic eczema, psoriasis, viral exanthemata, pemphigus, dermatitis herpetiformis, rosacea, and multiple sclerosis.(({{pmid>long:11744394}})) (({{pmid>long:17893968}})) (({{pmid>long:19906495}}))  Even so, the variety of [[home:diseases|MP treatable illnesses]] for which there is a photosensitivity component and the severity of the photosensitivity reaction is widely underestimated by the majority of clinicians and researchers. This may be due to the time window for an adverse reaction, which is often hours or days after light exposure.
  
 The photosensitivity observed among the MP patient cohort is not due to the medications. It is part of the healing process. The photosensitivity observed among the MP patient cohort is not due to the medications. It is part of the healing process.
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-Note that photosensitivity occurs with sufficient frequency that it is [[http://www.rxlist.com/benicar-hct-drug.htm|listed as an adverse side effect]] for patients who take at least one form of Benicar, Benicar HCT, a form which contains [[home:othertreatments:diuretics|thiazide]], a diuretic which is contraindicated for MP patients. The reason why it is not more common is that people who take Benicar irregularly (by MP standards) have not taken it consistently enough for a full Benicar blockade to be in place.+Note that photosensitivity occurs with sufficient frequency that it is [[https://www.rxlist.com/benicar-hct-drug.htm|listed as an adverse side effect]] for patients who take at least one form of Benicar, Benicar HCT, a form which contains [[home:othertreatments:diuretics|thiazide]], a diuretic which is contraindicated for MP patients. The reason why it is not more common is that people who take Benicar irregularly (by MP standards) have not taken it consistently enough for a full Benicar blockade to be in place.
  
  
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 //**Trevor Marshall, PhD**// </blockquote> //**Trevor Marshall, PhD**// </blockquote>
  
-In patients who get enough natural light on their skin on a regular basis, 1,25-D can elevate high enough to become immunosuppressive and stop bacterial killing. A study of frequent tanners found that the practice has an addictive quality – an effect which, according to the Marshall Pathogenesis, is due to systematic immunosuppression of high levels of 1,25-D.(({{pubmed>long:16546596}})) +In patients who get enough natural light on their skin on a regular basis, 1,25-D can elevate high enough to become immunosuppressive and stop bacterial killing. A study of frequent tanners found that the practice has an addictive quality – an effect which, according to the Marshall Pathogenesis, is due to systematic immunosuppression of high levels of 1,25-D.(({{pmid>long:16546596}})) 
  
 However, most MP patients do //not// get enough regular continuous light exposure on their skin to offset the olmesartan (Benicar) blockade. They can, however, get a surge of natural light exposure that causes an increase in symptoms due to rapid fluctuation of hormones including 1,25-D. However, most MP patients do //not// get enough regular continuous light exposure on their skin to offset the olmesartan (Benicar) blockade. They can, however, get a surge of natural light exposure that causes an increase in symptoms due to rapid fluctuation of hormones including 1,25-D.
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 === Skin may not be the major producer of 25-D ===  === Skin may not be the major producer of 25-D === 
  
-A recent study in mice cast doubt upon the skin as a major producer of 25-D, even though they it was shown that UV exposure on the skin likely does suppress the immune system through multiple pathways.(({{pubmed>long:20308557}})) It is possible the effect on the body is to cause the catalysis of 25-D systemically, although nobody seems quite sure of that just yet.+A recent study in mice cast doubt upon the skin as a major producer of 25-D, even though they it was shown that UV exposure on the skin likely does suppress the immune system through multiple pathways.(({{pmid>long:20308557}})) It is possible the effect on the body is to cause the catalysis of 25-D systemically, although nobody seems quite sure of that just yet.
  
  
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 ==== Neurological symptoms ==== ==== Neurological symptoms ====
  
-The optic nerve directly connects each eye to the brain, possibly the body's most sensitive organ. Thus, light is transmitted to the brain via the eyes. Coursing through the portion of the brain known as the amygdala are nerves connecting it to a number of important brain centers, including the neocortex and visual cortex. Many types of angiotensin receptors are known to be active in the brain. This can have the profound effect of stimulating portions of the brain to cause significant neurological symptoms.+The optic nerve directly connects each eye to the brain, possibly the body's most sensitive organ. Thus light is transmitted to the brain via the eyes. Coursing through the portion of the brain known as the amygdala are nerves connecting it to a number of important brain centers, including the neocortex and visual cortex. Many types of angiotensin receptors are known to be active in the brain. This can have the profound effect of stimulating portions of the brain to cause significant neurological symptoms.
  
 This stimulation of the brain causes many of the neurological symptoms that are so bothersome to individuals with Th1 inflammation. Neurological symptoms include fatigue, irritability, aggressiveness, lack of concentration, brain fog, loss of memory, poor judgement, confusion, anger (Lyme rage), mood swings, anxiety, inattentiveness, poor problem-solving, fear, neurosis and even psychosis. This stimulation of the brain causes many of the neurological symptoms that are so bothersome to individuals with Th1 inflammation. Neurological symptoms include fatigue, irritability, aggressiveness, lack of concentration, brain fog, loss of memory, poor judgement, confusion, anger (Lyme rage), mood swings, anxiety, inattentiveness, poor problem-solving, fear, neurosis and even psychosis.
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 ===== Immunopathology or photosensitivity symptoms? ===== ===== Immunopathology or photosensitivity symptoms? =====
  
 +This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction.  (({{pmid>long:30405625}})) 
  
-In the case of immunopathology – which is generated during the MP and a key part of the recovery process – inflammation from intracellular bacteria affects many areas of the brain, making it difficult to differentiate between neurological symptoms from light stimulation and from immunopathology. Dr. Brian Fallon's study on Lyme found from SPECT data that the main metabolic changes in the brain were in the region of the parahippocampal gyrus.(({{pubmed>long:12928508}})) This area is responsible for receiving sensory input from the outside world, integrating it, and projecting it onto the hippocampus, which controls memory, and the amygdala, which is in charge of fear, aggression, and mood. Negative symptoms associated with memory, fear, aggression, and mood can certainly be exacerbated by light.+ 
 +In the case of immunopathology – which is generated during the MP and a key part of the recovery process – inflammation from intracellular bacteria affects many areas of the brain, making it difficult to differentiate between neurological symptoms from light stimulation and from immunopathology. Dr. Brian Fallon's study on Lyme found from SPECT data that the main metabolic changes in the brain were in the region of the parahippocampal gyrus.(({{pmid>long:12928508}})) This area is responsible for receiving sensory input from the outside world, integrating it, and projecting it onto the hippocampus, which controls memory, and the amygdala, which is in charge of fear, aggression, and mood. Negative symptoms associated with memory, fear, aggression, and mood can certainly be exacerbated by light.
  
 There are two different and independent phenomena, which occur when one is on the MP, both of which are correlated with a temporary rapid rise in 1,25-D: photosensitivity symptoms and [[home:mp:immunopathology|immunopathology]]. Differentiating between immunopathology and photosensitivity symptoms is very important as the former is necessary for progress on the treatment and the latter is not.  There are two different and independent phenomena, which occur when one is on the MP, both of which are correlated with a temporary rapid rise in 1,25-D: photosensitivity symptoms and [[home:mp:immunopathology|immunopathology]]. Differentiating between immunopathology and photosensitivity symptoms is very important as the former is necessary for progress on the treatment and the latter is not. 
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 ===== Read more ===== ===== Read more =====
  
-  * [[http://en.wikipedia.org/wiki/Photophobia|Photophobia (Wikipedia)]] – lists diseases associated with light sensitivity +  * [[https://en.wikipedia.org/wiki/Photophobia|Photophobia (Wikipedia)]] – lists diseases associated with light sensitivity 
-  * [[http://www.livescience.com/6018-bright-light-worsens-migraine-headache-pain.html|Why Bright Light Worsens Migraine Headache Pain]]+  * [[https://www.livescience.com/6018-bright-light-worsens-migraine-headache-pain.html|Why Bright Light Worsens Migraine Headache Pain]]
  
  
 {{tag>Lifestyle_modifications light symptoms neurological}} {{tag>Lifestyle_modifications light symptoms neurological}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 Legacy content Legacy content
  
-  * http://www.marshallprotocol.com/forum2/1743.html +  * https://www.marshallprotocol.com/forum2/1743.html 
-  * http://www.marshallprotocol.com/view_topic.php?id=4&forum_id=2&jump_to=41820#p41820+  * https://www.marshallprotocol.com/view_topic.php?id=4&forum_id=2&jump_to=41820#p41820
  
  
  
-<blockquote>A neural mechanism for exacerbation of headache by light.(({{pubmed>long:20062053}}))+<blockquote>A neural mechanism for exacerbation of headache by light.(({{pmid>long:20062053}}))
  
 Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R.
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 PMID: 20062053 PMID: 20062053
  
-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818758/+https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818758/
  
 https://wiki.brown.edu/confluence/download/attachments/36634630/News+and+Views.pdf https://wiki.brown.edu/confluence/download/attachments/36634630/News+and+Views.pdf
  
-http://www.boston.com/news/health/articles/2010/01/11/light_worsens_migraines_in_blind_patients/</blockquote>+https://www.boston.com/news/health/articles/2010/01/11/light_worsens_migraines_in_blind_patients/</blockquote>
  
  
-<blockquote>http://www.drugs.com/news/depressed-see-gray-world-25712.html+<blockquote>https://www.drugs.com/news/depressed-see-gray-world-25712.html
  
 Depressed people actually 'see' the world around them in shades of gray, at least subconsciously, a new study suggests. Depressed people actually 'see' the world around them in shades of gray, at least subconsciously, a new study suggests.
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-===== References =====+===== References =====</nodisp> 
home/lifestyle/light/photosensitivity.1547239029.txt.gz · Last modified: 01.11.2019 by sallieq
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