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home:lifestyle:light:photosensitivity [09.01.2019] – [Neurological symptoms] sallieq | home:lifestyle:light:photosensitivity [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | Even though the exact mechanisms by which Th1 disease leads to photosensitivity remains clouded, photosensitivity is well associated with Th1 disease. Examples of photoaggravated diseases include lupus erythematosus, | + | Even though the exact mechanisms by which Th1 disease leads to photosensitivity remains clouded, photosensitivity is well associated with Th1 disease. Examples of photoaggravated diseases include lupus erythematosus, |
The photosensitivity observed among the MP patient cohort is not due to the medications. It is part of the healing process. | The photosensitivity observed among the MP patient cohort is not due to the medications. It is part of the healing process. | ||
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- | Note that photosensitivity occurs with sufficient frequency that it is [[http:// | + | Note that photosensitivity occurs with sufficient frequency that it is [[https:// |
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//**Trevor Marshall, PhD**// </ | //**Trevor Marshall, PhD**// </ | ||
- | In patients who get enough natural light on their skin on a regular basis, 1,25-D can elevate high enough to become immunosuppressive and stop bacterial killing. A study of frequent tanners found that the practice has an addictive quality – an effect which, according to the Marshall Pathogenesis, | + | In patients who get enough natural light on their skin on a regular basis, 1,25-D can elevate high enough to become immunosuppressive and stop bacterial killing. A study of frequent tanners found that the practice has an addictive quality – an effect which, according to the Marshall Pathogenesis, |
However, most MP patients do //not// get enough regular continuous light exposure on their skin to offset the olmesartan (Benicar) blockade. They can, however, get a surge of natural light exposure that causes an increase in symptoms due to rapid fluctuation of hormones including 1,25-D. | However, most MP patients do //not// get enough regular continuous light exposure on their skin to offset the olmesartan (Benicar) blockade. They can, however, get a surge of natural light exposure that causes an increase in symptoms due to rapid fluctuation of hormones including 1,25-D. | ||
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=== Skin may not be the major producer of 25-D === | === Skin may not be the major producer of 25-D === | ||
- | A recent study in mice cast doubt upon the skin as a major producer of 25-D, even though they it was shown that UV exposure on the skin likely does suppress the immune system through multiple pathways.(({{pubmed> | + | A recent study in mice cast doubt upon the skin as a major producer of 25-D, even though they it was shown that UV exposure on the skin likely does suppress the immune system through multiple pathways.(({{pmid> |
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===== Immunopathology or photosensitivity symptoms? ===== | ===== Immunopathology or photosensitivity symptoms? ===== | ||
- | This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, | + | This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, |
- | In the case of immunopathology – which is generated during the MP and a key part of the recovery process – inflammation from intracellular bacteria affects many areas of the brain, making it difficult to differentiate between neurological symptoms from light stimulation and from immunopathology. Dr. Brian Fallon' | + | In the case of immunopathology – which is generated during the MP and a key part of the recovery process – inflammation from intracellular bacteria affects many areas of the brain, making it difficult to differentiate between neurological symptoms from light stimulation and from immunopathology. Dr. Brian Fallon' |
There are two different and independent phenomena, which occur when one is on the MP, both of which are correlated with a temporary rapid rise in 1,25-D: photosensitivity symptoms and [[home: | There are two different and independent phenomena, which occur when one is on the MP, both of which are correlated with a temporary rapid rise in 1,25-D: photosensitivity symptoms and [[home: | ||
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===== Read more ===== | ===== Read more ===== | ||
- | * [[http:// | + | * [[https:// |
- | * [[http:// | + | * [[https:// |
{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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Legacy content | Legacy content | ||
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
- | < | + | < |
Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. | Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. | ||
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PMID: 20062053 | PMID: 20062053 | ||
- | http:// | + | https:// |
https:// | https:// | ||
- | http:// | + | https:// |
- | < | + | < |
Depressed people actually ' | Depressed people actually ' | ||
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- | ===== References ===== | + | ===== References =====</ |