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--- home:othertreatments:efas [04.02.2010] – external 127.0.0.1
+++ home:othertreatments:efas [09.04.2010] – paulalbert
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 Greater consumption of omega 3's has been shown to reduce inflammation and immune activity.(({{pubmed>long:19359242}}))
-  * **Omega 3's contain component which suppress TNF-alpha** – Cytokines are regulatory proteins, such as TNF-alpha, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. The omega 3 fatty acids, for example, contain several components which may interfere with the activity of TNF-alpha and other important cytokines.
+  * **Omega 3's contain components which suppress TNF-alpha** – Cytokines are regulatory proteins, such as TNF-alpha, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. The omega 3 fatty acids, for example, contain several components which may interfere with the activity of TNF-alpha and other important cytokines.
 <blockquote>Arachidonic acid (AA) significantly decreased TNFalpha production.... The results show that docosahexaenoic acid (DHA) induces a Th-1-like immune response and that AA has anti-inflammatory effects by decreasing the production of TNFalpha. **Thus, the immune effects of omega3 polysaturated fatty acids are not compatible with what is expected from antidepressive substances.** The results of the present study show that treatment with fish oils, containing DHA, should be avoided in the treatment of depression. Toward this end, highly concentrated and pure EPA seems to be indicated.
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 //**M. Bouwens**// (({{pubmed>long:19515734}}))</blockquote>
+  * **EPA and DHA switch off a key receptor responsible for innate immunity in fat cells.**  Olefsky and colleagues identified a key receptor on macrophages abundantly found in obese body fat: the GPR120 receptor.(({{pubmed>long:20813258}})) The team showed that omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects. [[http://www.eurekalert.org/pub_releases/2010-09/uoc--wfo083010.php|Commenting about his work]], Olefsky said, "It's just an incredibly potent effect. The omega-3 fatty acids switch on the receptor, killing the inflammatory response."
+===== Omega 3 fatty acids may cause disease =====
+  * **Mice given omega‐3's are more susceptible to pulmonary tuberculosis** – Bonilla //et al.// showed that  transgenic mice engineered to produce omega-3's endogenously (internally) increased their susceptibility to tuberculosis, which they explained by noting the corresponding reduction in antimycobacterial responses in cells. The researchers concluded, "These data suggest that n‐3 PUFA–supplemented [dietary omega‐3 fatty acids] diets might have a detrimental effect on immunity to //M. tuberculosis// and raise concerns regarding the safety of omega‐3 dietary supplementation in humans."(({{pubmed>long:20053136}}))

home/othertreatments/efas.txt · Last modified: 09.14.2022 by 127.0.0.1