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5. Schwerbrock NM, et al. J Nutr. 2009; | 5. Schwerbrock NM, et al. J Nutr. 2009; | ||
+ | < | ||
+ | Omega-3 linked to aggressive prostate cancer | ||
+ | By Laura Dean | ||
+ | 05 May 2011 | ||
+ | Am J Epidemiol 2011; Advance online publication | ||
+ | MedWire News: High levels of omega 3 (n-3) fatty acids, which are considered beneficial for coronary artery disease prevention, may increase the risk for high-grade prostate cancer, US research shows. | ||
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+ | In contrast, trans-fatty acids (TFAs), abundant in processed foods that contain partially hydrogenated vegetable oils and considered harmful, may reduce high-grade prostate cancer risk, report Theodore Brasky (Fred Hutchinson Cancer Research Center, Seattle, Washington) and colleagues. | ||
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+ | "We were stunned to see these results and we spent a lot of time making sure the analyses were correct," | ||
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+ | Brasky and team examined the association between inflammation-related phospholipid fatty acids (n-3, n-6, and TFAs) and prostate cancer risk because chronic inflammation is known to increase the risk of several cancers, and n-3 fatty acids, found primarily in fish and fish oil supplements, | ||
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+ | They conducted a case-control analysis of 3461 men (1658 cases and 1803 controls) aged 55-84 years, who participated in the Prostate Cancer Prevention Trial between 1994 and 2003. | ||
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+ | As reported in the American Journal of Epidemiology, | ||
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+ | In contrast, men with the highest levels of TFA 18:1 (>2.08% of total fatty acid) and TFA 18:2 (>0.26% of fatty acid) had a respective 45% and 52% lower risk for cancer than those with the lowest levels (<1.29% and <0.18% of total fatty acid, respectively). | ||
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+ | Of note, no other fatty acids were associated with high-grade prostate cancer risk, and none were associated with low-grade prostate cancer risk (Gleason scores 2-7). | ||
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+ | In spite of the findings, the researchers do not recommend that men should stop taking fish oil supplements or eating oily fish. " | ||
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+ | "A comprehensive understanding of the effects of nutrients on a broad range of diseases will be necessary before making recommendations for dietary changes or use of individual dietary supplements for disease prevention," | ||
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