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home:pathogenesis:familial_aggregation [06.09.2010] – paulalbert | home:pathogenesis:familial_aggregation [06.09.2010] – paulalbert | ||
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The reigning explanation for familial aggregation is that people pass down faulty genes to their offspring. | The reigning explanation for familial aggregation is that people pass down faulty genes to their offspring. | ||
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- | ===== Th1 pathogens are passed among family members | + | ===== Families |
< | < | ||
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The Th1 pathogens gradually mutate genetic pathways and cause disease by a process known as successive infection. | The Th1 pathogens gradually mutate genetic pathways and cause disease by a process known as successive infection. | ||
- | ==== Spouses | + | |
+ | ==== Spouses | ||
Several studies have shown that spouses have a greater chance of developing the same disease as their partners - a phenomenon that can best be explained if familial aggregation has an infectious cause. | Several studies have shown that spouses have a greater chance of developing the same disease as their partners - a phenomenon that can best be explained if familial aggregation has an infectious cause. | ||
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* **sarcoidosis** – A six-year study of the Th1 disease sarcoidosis, | * **sarcoidosis** – A six-year study of the Th1 disease sarcoidosis, | ||
* **hypertension** – Researchers at Queens Medical School in England found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects persisted after adjustment for other variables such as diet. (({{pubmed> | * **hypertension** – Researchers at Queens Medical School in England found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects persisted after adjustment for other variables such as diet. (({{pubmed> | ||
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==== Family members develop the same diseases ==== | ==== Family members develop the same diseases ==== | ||