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home:pathogenesis:vitamind:metabolism [06.07.2017] – [Mechanisms by which bacteria affect levels of 25-D and 1,25-D] sallieq | home:pathogenesis:vitamind:metabolism [01.01.2019] – [Metabolism of vitamin D and the Vitamin D Receptor] sallieq | ||
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Located in the nucleus of a variety of cells including immune cells, the VDR is a control system of sorts. When exposed to infection and damage, especially that which is caused by pathogens, the body begins to convert the inactive form 25-D into the active form, 1,25-D. As cellular concentrations of 1,25-D increase, 1,25-D activates the VDR, turning on any number of genes the receptor transcribes. | Located in the nucleus of a variety of cells including immune cells, the VDR is a control system of sorts. When exposed to infection and damage, especially that which is caused by pathogens, the body begins to convert the inactive form 25-D into the active form, 1,25-D. As cellular concentrations of 1,25-D increase, 1,25-D activates the VDR, turning on any number of genes the receptor transcribes. | ||
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According to a 2010 analysis, the VDR significantly affects 229 human genes. Many of these genes have long been associated with autoimmune diseases and cancers including, for example, the genes IRF8 (linked to multiple sclerosis), and PTPN2 (connected to Crohn' | According to a 2010 analysis, the VDR significantly affects 229 human genes. Many of these genes have long been associated with autoimmune diseases and cancers including, for example, the genes IRF8 (linked to multiple sclerosis), and PTPN2 (connected to Crohn' | ||
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- | * **synovial fluid surrounding the joints of patients with rheumatoid arthritis** – Mawer //et al// found that 1,25-D levels were particulary | + | * **synovial fluid surrounding the joints of patients with rheumatoid arthritis** – Mawer //et al// found that 1,25-D levels were particularly |
* **immune cells including macrophages** – Research has also shown that 1,25-D is synthesized in cells of the immune system, including the T cells and antigen-presenting cells(({{pubmed> | * **immune cells including macrophages** – Research has also shown that 1,25-D is synthesized in cells of the immune system, including the T cells and antigen-presenting cells(({{pubmed> | ||
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+ | ===== Read more research ===== | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
home/pathogenesis/vitamind/metabolism.txt · Last modified: 09.14.2022 by 127.0.0.1
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