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Poster - Multiple reports of symptom exacerbation on immunostimulatory treatment for autoimmune disease

Type: Poster presentation
Presented by: Paul Albert
Conference: Human MicrobiomeThe bacterial community in the human body. Many species in the microbiota contribute to the development of chronic disease. Research Conference
Location: Washington University, St. Louis
Date: August 31 - September 1, 2010
Additional Content: PDF of poster

Abstract

Over the past seven years, we have been observing patients with autoimmuneA condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body diagnoses use the VDRThe Vitamin D Receptor. A nuclear receptor located throughout the body that plays a key role in the innate immune response.-agonist olmesartanMedication taken regularly by patients on the Marshall Protocol for its ability to activate the Vitamin D Receptor. Also known by the trade name Benicar. to stimulate components of the innate immune responseThe body's first line of defense against intracellular and other pathogens. According to the Marshall Pathogenesis the innate immune system becomes disabled as patients develop chronic disease.. Nearly all of the hundreds of patient reported outcomes describe an initial increase in symptoms specific to their autoimmune diagnoses. Additionally, patients consistently report fluctuations in objective markers of inflammationThe complex biological response of vascular tissues to harmful stimuli such as pathogens or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. such as CRP, ACE, BUN, creatinine, and markers of liver function. After months of dealing with these fluctuations in disease state, symptomatic improvements begin to be reported, in some cases with objective markers indicating disease stabilization or remission. These symptomatic flares cannot easily be attributed to adverse events from olmesartan, as the drug is well known and unremarkable. Additionally, when healthy individuals have been administered the same medications, they suffer no similar symptoms. The most viable hypothesis for these symptomatic flares is that, by activating the innate immune system, olmesartan allows the body to mount an efective attack against pathogenic components of the microbiotaThe bacterial community which causes chronic diseases - one which almost certainly includes multiple species and bacterial forms.. For a century, researchers have noted that death of acute and persistent pathogens is accompanied by a surge in inflammation, endotoxin, and cytokineAny of various protein molecules secreted by cells of the immune system that serve to regulate the immune system. release. Known as Jarisch-Herxheimer, or immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed., this phenomenon has been demonstrated in numerous diseases. Olmesartan seems to be generating immunopathology. These preliminary results also indicate immunopathology may be a necessary part of reducing the metagenomic load in patients with autoimmune diagnoses.

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