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--- home:publications:marshall_autoimmunity_2010 [06.04.2010] – joyful
+++ home:publications:marshall_autoimmunity_2010 [09.10.2010] – paulalbert
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 **Location:** Ljubljana, Slovenia\\
 **Date:**  May 2010\\
+===== Abstract =====
+Although early-stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR Nuclear Receptor, which is at the heart of the human innate immune system. Only in Homo sapiens is the VDR responsible for expression of the Cathelicidin anti-microbial peptide, the primary defense of the intra-phagocytic innate immune system. The VDR is also responsible for expression of TLR2 and TACO and a number of other endogenous anti-microbials. Pathogens already known to persist by dysregulating the VDR include EBV, Mycobacteria, Borrelia and HIV. Antibacterial therapy is difficult, as the diseased VDR cannot be simply restored by Vitamin D metabolites, as it can in healthy individuals. The drug Olmesartan functions as a VDR agonist, restoring enough immune function for patients to again become responsive to bacteriostatic antibiotics. Indeed, care must be exercised to ensure the resulting cytokine-storm does not become life-threatening. VDR dysfunction results in ripple-down effects on the Thyroid, Glucocorticoid, Androgen and Progesterone receptors, which often return to normal in earlier years of the recovery process. New in silico research methodologies, including sequencing, modeling, and molecular-dynamics, have become essential tools in developing our understanding of the metagenomic microbiota which drives autoimmune disease, and how it interacts with the human genomes transcription and DNA repair mechanisms. An accurate model of disease processes is the essential factor in quickly moving these discoveries from bench to bedside.
 ===== Transcript =====
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 Vitamin D affects the immune system at many levels and by a number of mechanisms .. Vitamin D has multiple immunosuppressant properties .. On the whole, vitamin D confers an immunosuppressive effect.(({{pubmed>long:17557889}}))
-The possible involvement of vitamin D //deficiency// in the development of autoimmune diseases has recently gained interest .. the impact of the vitamin D pathway on immune function .. its influence on both autoimmune diseases and cancer should be further elucidated. (([[www.ima.org.il/imaj/ar10mar-11.pdf|The Role of Vitamin D in Regulating Immune Responses]]))
+The possible involvement of vitamin D //deficiency// in the development of autoimmune diseases has recently gained interest .. the impact of the vitamin D pathway on immune function .. its influence on both autoimmune diseases and cancer should be further elucidated. (([[http://www.ima.org.il/imaj/ar10mar-11.pdf|The Role of Vitamin D in Regulating Immune Responses]]))
 </blockquote>

home/publications/marshall_autoimmunity_2010.txt · Last modified: 09.14.2022 by 127.0.0.1