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**Type:** Conference presentation\\ | **Type:** Conference presentation\\ | ||
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+ | ===== Abstract ===== | ||
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+ | Although early-stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR Nuclear Receptor, which is at the heart of the human innate immune system. Only in Homo sapiens is the VDR responsible for expression of the Cathelicidin anti-microbial peptide, the primary defense of the intra-phagocytic innate immune system. The VDR is also responsible for expression of TLR2 and TACO and a number of other endogenous anti-microbials. Pathogens already known to persist by dysregulating the VDR include EBV, Mycobacteria, | ||
===== Transcript ===== | ===== Transcript ===== | ||
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- | Vitamin D affects the immune system at many levels and by a number of mechanisms .. Vitamin D has multiple immunosuppressant properties .. On the whole, vitamin D confers an immunosuppressive effect.(({{pubmed> | + | Vitamin D affects the immune system at many levels and by a number of mechanisms .. Vitamin D has multiple immunosuppressant properties .. On the whole, vitamin D confers an immunosuppressive effect.(({{pmid> |
- | The possible involvement of vitamin D // | + | The possible involvement of vitamin D // |
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- | Vitamin D is important because it's associated with a nuclear receptor called the VDR. The VDR is a nuclear receptor which is diagrammatically shown here as just one element inside a cell. You have a macrophage. Here a nucleus cytoplasm. All of the things going on in the cytoplasm. If you want more details you can look on Wikipedia, or you can look in Nature Clinical Practice at this citation here.(({{pubmed> | + | Vitamin D is important because it's associated with a nuclear receptor called the VDR. The VDR is a nuclear receptor which is diagrammatically shown here as just one element inside a cell. You have a macrophage. Here a nucleus cytoplasm. All of the things going on in the cytoplasm. If you want more details you can look on Wikipedia, or you can look in Nature Clinical Practice at this citation here.(({{pmid> |
The VDR is important both for adaptive immunity, the T and B lymphocyte function outside the macrophage. And it's particularly important for innate immunity. It transcribes cathelicidin, | The VDR is important both for adaptive immunity, the T and B lymphocyte function outside the macrophage. And it's particularly important for innate immunity. It transcribes cathelicidin, | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
Add this to heading after the PDF is completed: | Add this to heading after the PDF is completed: | ||
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- | <a href="http:// | + | <a href="https:// |
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- | ===== References ===== | + | ===== References =====</ |