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home:special:pregnancy [10.26.2018] – [Related publications and presentations] sallieqhome:special:pregnancy [09.14.2022] (current) – external edit 127.0.0.1
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 ===== MP may restore fertility ===== ===== MP may restore fertility =====
  
-For 60 years, doctors have believed women were born with all the eggs they'll ever have. Recently Harvard scientists are challenging that dogma, saying they've discovered the ovaries of young women harbor very rare stem cells capable of producing new eggs.(({{pubmed>long:22844256}})) This work suggests that formation of oocytes is driven by the biochemical environment, as is all stem cell activity.+For 60 years, doctors have believed women were born with all the eggs they'll ever have. Recently Harvard scientists are challenging that dogma, saying they've discovered the ovaries of young women harbor very rare stem cells capable of producing new eggs.(({{pmid>long:22844256}})) This work suggests that formation of oocytes is driven by the biochemical environment, as is all stem cell activity.
  
 The MP is a curative therapy. As the MP resolves inflammation, this healing will likely restore sexual capability and fertility. Any or all aspects of the MP, including avoiding vitamin D and sunlight/bright lights, may contribute to hormonal changes which lead to restoration of health and fertility in men or women. The MP is a curative therapy. As the MP resolves inflammation, this healing will likely restore sexual capability and fertility. Any or all aspects of the MP, including avoiding vitamin D and sunlight/bright lights, may contribute to hormonal changes which lead to restoration of health and fertility in men or women.
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-[{{ :home:pathogenesis:microbiota:gestationalage.gif|**Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery.** This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[http://www.ncbi.nlm.nih.gov/pubmed/18725970|DiGulio et al.]]}}]+[{{ :home:pathogenesis:microbiota:gestationalage.gif|**Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery.** This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[https://www.ncbi.nlm.nih.gov/pubmed/18725970|DiGulio et al.]]}}]
  
  
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 Microbes play an important factor in whether a woman will carry a pregnancy to term. Microbes play an important factor in whether a woman will carry a pregnancy to term.
  
-Using molecular tools to quantify bacterial count in pregnant women's amniotic fluid, DiGiulio //et al.// showed that the number of bacterial sequences found was inversely correlated with length of pregnancy.(({{pubmed>long:18725970}}))+Using molecular tools to quantify bacterial count in pregnant women's amniotic fluid, DiGiulio //et al.// showed that the number of bacterial sequences found was inversely correlated with length of pregnancy.(({{pmid>long:18725970}}))
  
-Also underscoring the importance of microbes in premature delivery is a 2010 paper showing that the injection of lipopolysaccharides (endotoxins) could create a mouse model for preterm labor.(({{pubmed>long:19995880}})) The release of endotoxins are well known byproducts of the immunopathological response, which is generated when gram-negative bacteria are destroyed.+Also underscoring the importance of microbes in premature delivery is a 2010 paper showing that the injection of lipopolysaccharides (endotoxins) could create a mouse model for preterm labor.(({{pmid>long:19995880}})) The release of endotoxins are well known byproducts of the immunopathological response, which is generated when gram-negative bacteria are destroyed.
  
-In recent years, the incidence of preterm deliveries has increased in the U.S. The National Center for Health Statistics (Centers for Disease Control and Prevention) has reported a 20% increase (from 10.6% to 12.7%) in the percentage of preterm deliveries during the years 1990–2005.(({{pubmed>long:18772340}}))+In recent years, the incidence of preterm deliveries has increased in the U.S. The National Center for Health Statistics (Centers for Disease Control and Prevention) has reported a 20% increase (from 10.6% to 12.7%) in the percentage of preterm deliveries during the years 1990–2005.(({{pmid>long:18772340}}))
 ==== Sarcoidosis ==== ==== Sarcoidosis ====
 The following describes some of the effects of sarcoidosis on pregnancy:  The following describes some of the effects of sarcoidosis on pregnancy: 
  
-  * Women with sarcoidosis report feeling better when they are pregnant. Sarcoidosis involves a Th1-activated immune system response. The NF-kappaB/IkappaB signaling pathway is down-regulated in T cells in pregnancy, shifting the immune system away from Th1 and toward a Th2 immune response.(({{pubmed>long:15034076}})) There are other factors to consider, especially vitamin D and sunlight exposure. These play a role in activation of NF-kappaB and the Th1 immune response. +  * Women with sarcoidosis report feeling better when they are pregnant. Sarcoidosis involves a Th1-activated immune system response. The NF-kappaB/IkappaB signaling pathway is down-regulated in T cells in pregnancy, shifting the immune system away from Th1 and toward a Th2 immune response.(({{pmid>long:15034076}})) There are other factors to consider, especially vitamin D and sunlight exposure. These play a role in activation of NF-kappaB and the Th1 immune response. 
-  * Pregnancy in women with sarcoidosis usually goes to term with no problems. Pregnant women diagnosed with sarcoidosis need to be aware, however, that some of the drug therapies (methotrexate, anti-malarials, Thalidomide, etc.) normally used for sarcoidosis are contraindicated in pregnancy. (({{pubmed>long:10637902}})) +  * Pregnancy in women with sarcoidosis usually goes to term with no problems. Pregnant women diagnosed with sarcoidosis need to be aware, however, that some of the drug therapies (methotrexate, anti-malarials, Thalidomide, etc.) normally used for sarcoidosis are contraindicated in pregnancy. (({{pmid>long:10637902}})) 
-  * Oral corticosteroids increase the risk of cleft palate.(({{pubmed>long:11091360}}))+  * Oral corticosteroids increase the risk of cleft palate.(({{pmid>long:11091360}}))
   * Regarding cesarian section versus vaginal delivery, consider that sarcoidosis inflammation is known to have an affinity for scar tissue.   * Regarding cesarian section versus vaginal delivery, consider that sarcoidosis inflammation is known to have an affinity for scar tissue.
  
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 ===== Risk of pre-term birth for expectant mothers taking multivitamins ===== ===== Risk of pre-term birth for expectant mothers taking multivitamins =====
  
-Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pubmed>long:20353456}})) +Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pmid>long:20353456}})) 
  
  
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-Santiago //et al.// collected swabs of vaginal microflora from 17 women over the course of two consecutive menstrual cycles. Researchers noted a rise in Gram positive cocci during menses.(({{pubmed>long:22140538}}))+Santiago //et al.// collected swabs of vaginal microflora from 17 women over the course of two consecutive menstrual cycles. Researchers noted a rise in Gram positive cocci during menses.(({{pmid>long:22140538}}))
 ===== Patients experiences ===== ===== Patients experiences =====
  
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 {{tag>Special_issues  special pregnancy}}  {{tag>Special_issues  special pregnancy}} 
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum32/2362.html f24 +    * https://www.marshallprotocol.com/forum32/2362.html f24 
-    * http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=37167#p37167 s39+    * https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=37167#p37167 s39
  
  
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 PMID: 19939856</blockquote> PMID: 19939856</blockquote>
  
-===== References =====+===== References =====</nodisp> 
home/special/pregnancy.txt · Last modified: 09.14.2022 by 127.0.0.1
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