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home:tests:25d [10.12.2018] – [Read more] sallieq | home:tests:25d [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | Lower than normal levels of 25-D have been independently associated both with all-cause mortality(({{pubmed> | + | Lower than normal levels of 25-D have been independently associated both with all-cause mortality(({{pmid> |
For this reason, low levels of 25-D can be used (in countries that supplement) as a [[home: | For this reason, low levels of 25-D can be used (in countries that supplement) as a [[home: | ||
===== Not a simple fat-soluble vitamin ===== | ===== Not a simple fat-soluble vitamin ===== | ||
- | A recent analysis concluded that surrogate markers for vitamin D exposure including age, vitamin D intake, supplement use, latitude, etc. taken together, could explain only 21 percent of the variation in vitamin D levels between people.(({{pubmed> | + | A recent analysis concluded that surrogate markers for vitamin D exposure including age, vitamin D intake, supplement use, latitude, etc. taken together, could explain only 21 percent of the variation in vitamin D levels between people.(({{pmid> |
- | As a 2010 Tasmanian study demonstrated, | + | As a 2010 Tasmanian study demonstrated, |
===== Reference range for 25-D ===== | ===== Reference range for 25-D ===== | ||
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Observational studies show that populations which avoid vitamin D consumption have naturally low levels of 25-D and remain healthy with such levels. | Observational studies show that populations which avoid vitamin D consumption have naturally low levels of 25-D and remain healthy with such levels. | ||
- | * A study which tested the level of 25-D in 90 “healthy, ambulatory Chilean women” showed that 27% of the premenopausal and 60% of the postmenopausal women had 25-D levels under 20 ng/ml. (({{pubmed> | + | * A study which tested the level of 25-D in 90 “healthy, ambulatory Chilean women” showed that 27% of the premenopausal and 60% of the postmenopausal women had 25-D levels under 20 ng/ml. (({{pmid> |
- | * A study on healthy Bangladeshi women found that approximately 80% of the women had a level of 25-D under 16 ng/ml. (({{pubmed> | + | * A study on healthy Bangladeshi women found that approximately 80% of the women had a level of 25-D under 16 ng/ml. (({{pmid> |
- | * In a 1992 study, healthy full-term infants from China had serum concentrations of 25-D ranging from an average of 5 ng/ml to 14 ng/ | + | * In a 1992 study, healthy full-term infants from China had serum concentrations of 25-D ranging from an average of 5 ng/ml to 14 ng/ |
==== Patients with chronic diseases naturally downregulate levels of 25-D ==== | ==== Patients with chronic diseases naturally downregulate levels of 25-D ==== | ||
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- | There are several molecular pathways activate in chronic inflammatory disease, which cause levels of 25-D to fall to " | + | There are several molecular pathways activate in chronic inflammatory disease, which cause levels of 25-D to fall to " |
Under such circumstances, | Under such circumstances, | ||
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- | The rate at which 25-D declines in Marshall Protocol patients tends to vary. Adams //et al.// (right) showed that the rate of at which 25-D declined among people who taken high amounts of vitamin D supplements and subsequently abstained from supplements is approximately 10.7 ± 3.0 nmol/L per month.(({{pubmed> | + | The rate at which 25-D declines in Marshall Protocol patients tends to vary. Adams //et al.// (right) showed that the rate of at which 25-D declined among people who taken high amounts of vitamin D supplements and subsequently abstained from supplements is approximately 10.7 ± 3.0 nmol/L per month.(({{pmid> |
===== Recalcitrant 25-D – why 25-D could remain high over the course of several years ===== | ===== Recalcitrant 25-D – why 25-D could remain high over the course of several years ===== | ||
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Here are several factors may play a role in contributing to unexpected levels of 25-D: | Here are several factors may play a role in contributing to unexpected levels of 25-D: | ||
- | * **Yeast may be able to produce a 25-D precursor** – Patients who have large yeast overgrowth such as //Candida// may have elevated levels of 25-D as //Candida// produces ergosterol, a Vitamin D2 precursor.(({{pubmed> | + | * **Yeast may be able to produce a 25-D precursor** – Patients who have large yeast overgrowth such as //Candida// may have elevated levels of 25-D as //Candida// produces ergosterol, a Vitamin D2 precursor.(({{pmid> |
< | < | ||
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{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | * Vitamin D: More May Not Be Better; Benefits in Healthy Adults Wear Off at Higher Doses, Research Suggests ... http:// | + | * Vitamin D: More May Not Be Better; Benefits in Healthy Adults Wear Off at Higher Doses, Research Suggests ... https:// |
"Above 21 nanograms per milliliters, | "Above 21 nanograms per milliliters, | ||
* Need to find page to put link to for the d-metabolite feedback diagram. | * Need to find page to put link to for the d-metabolite feedback diagram. | ||
* Legacy content | * Legacy content | ||
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
Question, when both D2 & D3 are measured, is the D3 result alone considered the 25D value? | Question, when both D2 & D3 are measured, is the D3 result alone considered the 25D value? | ||
- | * http:// | + | * https:// |
- | * http:// | + | * https:// |
Also, what about claims that Quest' | Also, what about claims that Quest' | ||
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I'm really surprised that this kind of thing is going on! | I'm really surprised that this kind of thing is going on! | ||
- | Zeta brought the Cannell/ | + | Zeta brought the Cannell/ |
I'm going to find out about the method used by my Lab, and Jacqueline I really appreciate that you brought this topic up again! | I'm going to find out about the method used by my Lab, and Jacqueline I really appreciate that you brought this topic up again! | ||
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Here are some of the links I checked: | Here are some of the links I checked: | ||
- | http:// | + | https:// |
- | http:// | + | https:// |
- | http:// | + | https:// |
- | http:// | + | https:// |
- | http:// | + | https:// |
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Roux-en-y gastric bypass (RYGB) surgery is associated with dramatic improvements in obesity-related comorbidity, | Roux-en-y gastric bypass (RYGB) surgery is associated with dramatic improvements in obesity-related comorbidity, | ||
- | The study discussed here: [[http:// | + | The study discussed here: [[https:// |
- | ===== References ===== | + | ===== References =====</ |