This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revisionNext revision | Previous revision | ||
home:tests:kidney [01.15.2019] – [Comment] + 4 kidney test found in 2010 TM post sallieq | home:tests:kidney [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 24: | Line 24: | ||
Olmesartan has two key properties: Vitamin D Receptor agonist and potent anti-inflammatory. While it may seem logical to discontinue olmesartan given that it stimulates the immune response, leading to immunopathology and subsequently elevated kidney values, abruptly withdrawing olmesartan can be dangerous. | Olmesartan has two key properties: Vitamin D Receptor agonist and potent anti-inflammatory. While it may seem logical to discontinue olmesartan given that it stimulates the immune response, leading to immunopathology and subsequently elevated kidney values, abruptly withdrawing olmesartan can be dangerous. | ||
- | By reducing inflammation, | + | By reducing inflammation, |
Instead of discontinuing olmesartan, physicians are advised to work with their patients to employ [[home: | Instead of discontinuing olmesartan, physicians are advised to work with their patients to employ [[home: | ||
Line 33: | Line 33: | ||
The benefits of olmesartan on patients with kidney inflammation include: | The benefits of olmesartan on patients with kidney inflammation include: | ||
- | * decreased insulin resistance, fewer symptoms of the metabolic syndrome, and decreased inflammation in patients with chronic kidney disease.(({{pubmed> | + | * decreased insulin resistance, fewer symptoms of the metabolic syndrome, and decreased inflammation in patients with chronic kidney disease.(({{pmid> |
- | * the ability to ameliorate renal injury and fibrosis in rats when taken at ultrahigh doses.(({{pubmed> | + | * the ability to ameliorate renal injury and fibrosis in rats when taken at ultrahigh doses.(({{pmid> |
- | * decreased (intra)renal vascular resistance, increased renal perfusion, and significantly reduced oxidative stress in patients with type 2 diabetes(({{pubmed> | + | * decreased (intra)renal vascular resistance, increased renal perfusion, and significantly reduced oxidative stress in patients with type 2 diabetes(({{pmid> |
- | * protection of the kidneys in diabetic nephropathy(({{pubmed> | + | * protection of the kidneys in diabetic nephropathy(({{pmid> |
- | * offer a survival benefit in hemodialysis patients, may help in preservation of renal function in predialysis patient, and affect the tissue repair process, reducing renal fibrosis(({{pubmed> | + | * offer a survival benefit in hemodialysis patients, may help in preservation of renal function in predialysis patient, and affect the tissue repair process, reducing renal fibrosis(({{pmid> |
===== Recent studies of Olmesartan in patients ===== | ===== Recent studies of Olmesartan in patients ===== | ||
Line 46: | Line 46: | ||
For MP patients with disease involvement in the kidneys, kidney-specific metabolites may increase in a way that is consistent with an active or activated immune response. The following research support this idea: | For MP patients with disease involvement in the kidneys, kidney-specific metabolites may increase in a way that is consistent with an active or activated immune response. The following research support this idea: | ||
- | * **BUN** – One study found that hemodialysis patients who had high serum values of urea nitrogen (BUN) were less likely to have the acute infection, // | + | * **BUN** – One study found that hemodialysis patients who had high serum values of urea nitrogen (BUN) were less likely to have the acute infection, // |
- | * **creatinine** – According to Goldstein, clinicians caring for patients with acute kidney injury (AKI) have been hindered by the reliance on serum creatinine or decreased urine output, both kidney function markers, to make the AKI diagnosis. Even more vexing is the fact that similar serum creatinine changes can occur without kidney damage, for example in the context of dehydration, | + | * **creatinine** – According to Goldstein, clinicians caring for patients with acute kidney injury (AKI) have been hindered by the reliance on serum creatinine or decreased urine output, both kidney function markers, to make the AKI diagnosis. Even more vexing is the fact that similar serum creatinine changes can occur without kidney damage, for example in the context of dehydration, |
- | In a 2011 study appearing in //Kidney International//, | + | In a 2011 study appearing in //Kidney International//, |
Line 55: | Line 55: | ||
In conclusion, VDR activation may alter creatinine metabolism. An increase in creatinine generation may lead to an increase in serum creatinine and, if eGFR is used to measure kidney function, it may give the appearance that kidney function is declining when truly it may not be altered. | In conclusion, VDR activation may alter creatinine metabolism. An increase in creatinine generation may lead to an increase in serum creatinine and, if eGFR is used to measure kidney function, it may give the appearance that kidney function is declining when truly it may not be altered. | ||
- | //**Rajiv Agarwal** et al.//(({{pubmed> | + | //**Rajiv Agarwal** et al.//(({{pmid> |
</ | </ | ||
Line 111: | Line 111: | ||
< | < | ||
- | Creatinine inhibits bacterial replication //Thomas McDonald, Kristen M Drescher, Annika Weber and Steven Tracy// | + | Creatinine inhibits bacterial replication //Thomas McDonald, Kristen M Drescher, Annika Weber and Steven Tracy// |
Line 119: | Line 119: | ||
{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
Line 126: | Line 127: | ||
This article talks about how bacteria can lead to release of nitric oxide: | This article talks about how bacteria can lead to release of nitric oxide: | ||
- | http:// | + | https:// |
- | Blood Urea Nitrogen test is [[http:// | + | Blood Urea Nitrogen test is [[https:// |
Line 161: | Line 162: | ||
- | < | + | < |
- | http:// | + | https:// |
Line 183: | Line 184: | ||
It is not uncommon for creatinine levels to rise while having immunopathology during the MP. All of the usual methods for [[: | It is not uncommon for creatinine levels to rise while having immunopathology during the MP. All of the usual methods for [[: | ||
- | The creatinine test is [[http:// | + | The creatinine test is [[https:// |
- | A good article to review is "[[http:// | + | A good article to review is "[[https:// |
Also, for more information, | Also, for more information, | ||
Line 204: | Line 205: | ||
" | " | ||
- | http:// | + | https:// |
From Gary's progress (garyv). | From Gary's progress (garyv). | ||
- | http:// | + | https:// |
(Gary does not report any ill health. He works an IT job and actively maintains his farm while on the MP.) | (Gary does not report any ill health. He works an IT job and actively maintains his farm while on the MP.) | ||
Lab results (2010): | Lab results (2010): | ||
Line 223: | Line 224: | ||
From CaptBubba' | From CaptBubba' | ||
- | http:// | + | https:// |
(She posts in the medical professional' | (She posts in the medical professional' | ||
Lab results (2010): | Lab results (2010): | ||
Line 238: | Line 239: | ||
From Claire' | From Claire' | ||
- | http:// | + | https:// |
Lab results: | Lab results: | ||
| | ||
Line 248: | Line 249: | ||
From Freddie' | From Freddie' | ||
- | http:// | + | https:// |
Lab results: | Lab results: | ||
BUN | BUN | ||
Line 264: | Line 265: | ||
From: Dr Trevor Marshall | From: Dr Trevor Marshall | ||
Date: 2010-09-06 16:15:30 | Date: 2010-09-06 16:15:30 | ||
- | Reply: | + | Reply: |
- | Verena, even though eGFR values frequently drop into the twenties, and occasionally into the teens, there has been no kidney failure. Nobody has needed dialysis, and it would be ludicrous for anybody to have been biopsied under these circumstances. | + | Varia, even though eGFR values frequently drop into the twenties, and occasionally into the teens, there has been no kidney failure. Nobody has needed dialysis, and it would be ludicrous for anybody to have been biopsied under these circumstances. |
We have seen really high Creatinine, we should dig out these values and put them in the MPKB. I don't recall the values off the top of my head... | We have seen really high Creatinine, we should dig out these values and put them in the MPKB. I don't recall the values off the top of my head... | ||
- | http:// | + | https:// |
Line 288: | Line 289: | ||
- | < | + | < |
</ | </ | ||
Line 357: | Line 358: | ||
</ | </ | ||
- | ===== References ===== | + | ===== References =====</ |