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home:diseases:alzheimers_dementia [10.25.2017] – [Role of the Vitamin D Receptor] added section 'Other immune suppression' sallieqhome:diseases:alzheimers_dementia [02.21.2019] – [Role of the Vitamin D Receptor] sallieq
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 We are excited that someone [the team of Harvard researchers who first identified amyloid beta as an antimicrobial petide] is thinking out of the box in ways that others haven't considered. Most of the evidence about infections and AD has been ignored. The Harvard researchers are going about this in a rational way. It's not such a radical idea. HIV can trigger dementia. Why not other organisms? We are excited that someone [the team of Harvard researchers who first identified amyloid beta as an antimicrobial petide] is thinking out of the box in ways that others haven't considered. Most of the evidence about infections and AD has been ignored. The Harvard researchers are going about this in a rational way. It's not such a radical idea. HIV can trigger dementia. Why not other organisms?
  
-//**Brian Balin, PhD**, [[http://journals.lww.com/neurotodayonline/Fulltext/2010/05060/New_Study_Theorizes_that_Amyloid_Beta_Protein_is.9.aspx|NeurologyToday]] (subscription required)//+//**Brian Balin, PhD**, [[http://journals.lww.com/neurotodayonline/Fulltext/2010/05060/New_Study_Theorizes_that_Amyloid_Beta_Protein_is.9.aspx|NeurologyToday]] //
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 The similarities between Abeta [amyloid beta] and antimicrobials had been staring us in the face for decades. Abeta looks in size, structure, and biochemical properties like an antimicrobial peptide [called LL-37]. In fact, we have shown that it is a bonafide antimicrobial peptide. The similarities between Abeta [amyloid beta] and antimicrobials had been staring us in the face for decades. Abeta looks in size, structure, and biochemical properties like an antimicrobial peptide [called LL-37]. In fact, we have shown that it is a bonafide antimicrobial peptide.
  
-//**Rudolph E. Tanzi, PhD**, [[http://journals.lww.com/neurotodayonline/Fulltext/2010/05060/New_Study_Theorizes_that_Amyloid_Beta_Protein_is.9.aspx|NeurologyToday]] (subscription required)//+//**Rudolph E. Tanzi, PhD**, [[http://journals.lww.com/neurotodayonline/Fulltext/2010/05060/New_Study_Theorizes_that_Amyloid_Beta_Protein_is.9.aspx|NeurologyToday]]//
 </blockquote> </blockquote>
  
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 According to the Marshall Pathogenesis, microbes subvert immune activity by suppressing expression of key nuclear receptors involved in innate immune activity such as the Vitamin D Receptor. The fact that over-production of amyloid suppresses the VDR suggests a role of VDR dysfunction in the Alzheimer's disease process. Indeed, a 2010 study in //Journal of Alzheimer's Disease// showed that the amyloids trigger neurodegeneration not only by inducing LVSCC A1C expression and NGF levels, but also by dramatically suppressing VDR expression.(({{pubmed>long:20966550}}))  According to the Marshall Pathogenesis, microbes subvert immune activity by suppressing expression of key nuclear receptors involved in innate immune activity such as the Vitamin D Receptor. The fact that over-production of amyloid suppresses the VDR suggests a role of VDR dysfunction in the Alzheimer's disease process. Indeed, a 2010 study in //Journal of Alzheimer's Disease// showed that the amyloids trigger neurodegeneration not only by inducing LVSCC A1C expression and NGF levels, but also by dramatically suppressing VDR expression.(({{pubmed>long:20966550}})) 
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 +Roles of Brain Angiotensin II in Cognitive Function and Dementia.  (({{pubmed>long:23304450}})) 
  
 ==== Other immune suppression ==== ==== Other immune suppression ====
home/diseases/alzheimers_dementia.txt · Last modified: 09.14.2022 by 127.0.0.1
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