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home:diseases:alzheimers_dementia [02.11.2019]
sallieq [Evidence of infectious cause]
home:diseases:alzheimers_dementia [02.21.2019] (current)
sallieq [Role of the Vitamin D Receptor]
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 According to the Marshall Pathogenesis,​ microbes subvert immune activity by suppressing expression of key nuclear receptors involved in innate immune activity such as the Vitamin D Receptor. The fact that over-production of amyloid suppresses the VDR suggests a role of VDR dysfunction in the Alzheimer'​s disease process. Indeed, a 2010 study in //Journal of Alzheimer'​s Disease// showed that the amyloids trigger neurodegeneration not only by inducing LVSCC A1C expression and NGF levels, but also by dramatically suppressing VDR expression.(({{pubmed>​long:​20966550}})) ​ According to the Marshall Pathogenesis,​ microbes subvert immune activity by suppressing expression of key nuclear receptors involved in innate immune activity such as the Vitamin D Receptor. The fact that over-production of amyloid suppresses the VDR suggests a role of VDR dysfunction in the Alzheimer'​s disease process. Indeed, a 2010 study in //Journal of Alzheimer'​s Disease// showed that the amyloids trigger neurodegeneration not only by inducing LVSCC A1C expression and NGF levels, but also by dramatically suppressing VDR expression.(({{pubmed>​long:​20966550}})) ​
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 +Roles of Brain Angiotensin II in Cognitive Function and Dementia. ​ (({{pubmed>​long:​23304450}})) ​
  
 ==== Other immune suppression ==== ==== Other immune suppression ====
home/diseases/alzheimers_dementia.txt · Last modified: 02.21.2019 by sallieq
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