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home:food:aim_health:aging [02.24.2019] – [Recent studies showed] sallieq | home:food:aim_health:aging [03.13.2019] – [with additional studies] sallieq | ||
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===== with additional studies ===== | ===== with additional studies ===== | ||
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+ | Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. | ||
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+ | Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. | ||
Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pubmed> | Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pubmed> | ||
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* in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pubmed> | * in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pubmed> | ||
* results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pubmed> | * results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pubmed> | ||
- | * renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed> | + | * renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed> |
* olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects | * olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects | ||