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home:food:aim_health:aging [02.24.2019] – [Recent studies showed] sallieqhome:food:aim_health:aging [04.20.2019] – [with additional studies] sallieq
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 ===== with additional studies ===== ===== with additional studies =====
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 +Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering.  (({{pubmed>long:16236804}})) 
  
  Although uncontrolled confounding might still exist, (//this was a short term study//) olmesartan does not seem to increase cardiovascular risk compared with losartan. (({{pubmed>long:24516110}}))   Although uncontrolled confounding might still exist, (//this was a short term study//) olmesartan does not seem to increase cardiovascular risk compared with losartan. (({{pubmed>long:24516110}})) 
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  Benefits of RAS blockade with olmesartan treatment are sustained after study discontinued.  (({{pubmed>long:24772521}}))  Benefits of RAS blockade with olmesartan treatment are sustained after study discontinued.  (({{pubmed>long:24772521}}))
 +
 +Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells.   (in breast cancer)(({{pubmed>long:    26138656}}))
  
 Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pubmed>long:27082551}}))  Data demonstrate potential benefits of reducing the heart rate of type 2 diabetes patients, and indicate that olmesartan could, in particular, reduce the risk of microalbuminuria in patients with low heart rate. (({{pubmed>long:27082551}})) 
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 Administration of olmesartan suppressed the accumulation of macrophages in  brachiocephalic atherosclerotic plaque. (in mice) (({{pubmed>long:    20079903}}))  Administration of olmesartan suppressed the accumulation of macrophages in  brachiocephalic atherosclerotic plaque. (in mice) (({{pubmed>long:    20079903}})) 
  
-Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (**3 mg/kg**) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat) +Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (**3 mg/kg**) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat) (({{pubmed>long:    20074257}}))
  
 Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats.  (({{pubmed>long:24379062}}))  Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats.  (({{pubmed>long:24379062}})) 
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   * in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pubmed>long:23154587}}))    * in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition (({{pubmed>long:23154587}})) 
   * results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pubmed>long:22149003}}))    * results suggest olmesartan can help decrease plasma AGE levels in patients on Hemodialysis (({{pubmed>long:22149003}})) 
-  * renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed>long:3862195}})) +  * renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed>long:24384547}}))     
   * olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects  (({{pubmed>long:24842388}}))    * olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects  (({{pubmed>long:24842388}})) 
  
home/food/aim_health/aging.txt · Last modified: 09.14.2022 by 127.0.0.1
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