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Chlorogenic acidAn antioxidant and phenolic compound which in ways that are not yet fully clear can modulate and/or suppress the immune response is an antioxidant and phenolic compound, which, in ways that are not yet fully clear, can modulate and/or suppress the immune response. The effect of chlorogenic acid and genistein on the immune system is dose-dependent. Consumption of foods containing these substances by Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP) patients is not prohibited, however, MP patients are advised to exercise moderation when consuming foods and drinks high in chlorogenic acid.
The quantity of chlorogenic acid in most plants is miniscule. However, a few types of plants accumulate chlorogenic acid, especially in the skin, in quantities sufficient to have a physiological effect on individuals who consume them. These foods include:
(High content) * coffee * sunflower seeds * tea * blueberries
(Lower content, but still higher than most other foods) * Chinese parsley * potatoes * tomatoes * apples * pears * tobacco * eggplant
MP patients should avoid juicing, which greatly concentrates substances in fruits, to prevent ingesting too much chlorogenic acid and other phytochemicals.
The primary dietary sources of chlorogenic acid are coffee and tea1), both caffeinated and decaffeinated. Green coffee beans typically contain 6-7% of this component (range: 4-10%); roasted coffee beans contain somewhat less, as the roasting transforms chlorogenic acid into other molecules, which may still retain the same functions as chlorogenic acid.
MP patients should limit their daily coffee consumption to no more than two cups per day.
Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine “Additionally, these effects are altered by regular caffeine intake and fitness level, emphasizing that tolerance and immune robustness are important factors in mononuclear phagocyte activation.” 2)
Health benefits of methylxanthines in cacao and chocolate. 3)
Quercetin, not caffeine, is a major neuroprotective component in both caffeinated and decaffeinated coffee. 4)
Caffeine triggers epinephrine/adrenaline release and we know that there are bacterial species whose behavior is affected by epinephrine.
We have identified this signal as the hormone epinephrine and show that β- and α-adrenergic antagonists can block the bacterial response to this hormone. 5)
If consuming any food results in intolerable symptoms, such as migraine headache or gastric upset, chlorogenic acid content or another substance in the food may be the cause.
Following an elimination diet can help a MP patient determine which foods to avoid in order to maintain tolerable symptoms while on the MP. Many symptoms suggestive of food sensitivity may also be due to immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed.. Food sensitivites should resolve as the MP resolves Th1 inflammationThe complex biological response of vascular tissues to harmful stimuli such as pathogens or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue..