Chlorogenic acid

Chlorogenic acid is an antioxidant and phenolic compound, which, in ways that are not yet fully clear, can modulate and/or suppress the immune response. The effect of chlorogenic acid and genistein on the immune system is dose-dependent. Consumption of foods containing these substances by Marshall Protocol (MP) patients is not prohibited, however, MP patients are advised to exercise moderation when consuming foods and drinks high in chlorogenic acid.

Foods with chlorogenic acid

The quantity of chlorogenic acid in most plants is miniscule. However, a few types of plants accumulate chlorogenic acid, especially in the skin, in quantities sufficient to have a physiological effect on individuals who consume them. These foods include:

(High content)
* coffee
* sunflower seeds
* tea
* blueberries
(Lower content, but still higher than most other foods)
* Chinese parsley
* potatoes
* tomatoes
* apples
* pears
* tobacco
* eggplant 


MP patients should avoid juicing, which greatly concentrates substances in fruits, to prevent ingesting too much chlorogenic acid and other phytochemicals.

Coffee and tea

The primary dietary sources of chlorogenic acid are coffee and tea1), both caffeinated and decaffeinated. Green coffee beans typically contain 6-7% of this component (range: 4-10%); roasted coffee beans contain somewhat less, as the roasting transforms chlorogenic acid into other molecules, which may still retain the same functions as chlorogenic acid.

MP patients should limit their daily coffee consumption to no more than two cups per day.

Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine “Additionally, these effects are altered by regular caffeine intake and fitness level, emphasizing that tolerance and immune robustness are important factors in mononuclear phagocyte activation.” 2)

Is There a Relation between Adenosine and Caffeines’ Mechanisms of Action and Toll-Like Receptor-4 (TLR-4)?.



Health benefits of methylxanthines in cacao and chocolate. 3)

Quercetin, not caffeine, is a major neuroprotective component in both caffeinated and decaffeinated coffee. 4)

Caffeine triggers epinephrine/adrenaline release and we know that there are bacterial species whose behavior is affected by epinephrine.

We have identified this signal as the hormone epinephrine and show that β- and α-adrenergic antagonists can block the bacterial response to this hormone. 5)

Food sensitivities

If consuming any food results in intolerable symptoms, such as migraine headache or gastric upset, chlorogenic acid content or another substance in the food may be the cause.

Following an elimination diet can help a MP patient determine which foods to avoid in order to maintain tolerable symptoms while on the MP. Many symptoms suggestive of food sensitivity may also be due to immunopathology. Food sensitivites should resolve as the MP resolves Th1 inflammation.

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===== Notes and comments =====

Sallie Q 01.30.2017 from https://www.marshallprotocol.com/forum35/15030-3.html Joyful posted to Tapsa “coffee, tea and foods high in CGA in some people has possibly created a sensitivity to olmesartan.” AND “CGA (I'll give links later) binds into the VDRs of our cells that the olmesartan is intended to activate. … The main concern, based on your previous experience is that the CGA molecule was thought to be shaped similar to Vitamin D (and olmesartan) and could cause you to become sensitized to olmesartan again.”

quantity of chlorogenic acid removed, because continues to time out ===== References =====

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Olthof MR, Hollman PC, Zock PL, Katan MB. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr. 2001 Mar;73(3):532-8. doi: 10.1093/ajcn/73.3.532.
[PMID: 11237928] [DOI: 10.1093/ajcn/73.3.532]
Steck RP, Hill SL, Weagel EG, Weber KS, Robison RA, O'Neill KL. Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine. Pharmacol Res Perspect. 2015 Oct 25;3(6):e00180. doi: 10.1002/prp2.180. eCollection 2015 Dec.
[PMID: 27022462] [PMCID: 4777255] [DOI: 10.1002/prp2.180]
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Lee M, McGeer EG, McGeer PL. Quercetin, not caffeine, is a major neuroprotective component in coffee. Neurobiol Aging. 2016 Oct;46:113-23. doi: 10.1016/j.neurobiolaging.2016.06.015. Epub 2016 Jul 5.
[PMID: 27479153] [DOI: 10.1016/j.neurobiolaging.2016.06.015]
Sperandio V, Torres AG, Jarvis B, Nataro JP, Kaper JB. Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8951-6. doi: 10.1073/pnas.1537100100. Epub 2003 Jul 7.
[PMID: 12847292] [PMCID: 166419] [DOI: 10.1073/pnas.1537100100]
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