Anticoagulant therapy has been proposed by some as a way of resolving the “sticky blood” seen in some patients with chronic diseases. Generally speaking, anticoagulants introduce a certain amount of unpredictability. All of the anticoagulants contribute to hormonal instability, and heparin has some antimicrobial effects.1)

I think the fibrin that has been focused upon is a result of the bacterial infectious process, and not necessarily the cause of the disease, or of its symptoms. In my opinion, getting rid of the bacteria will remove the secondary problems, which include fibrin formation, neuropathy, etc. … It seems to me that although anticoagulation therapy definitely helps some patients to feel better, it does not help them heal. Indeed, the dangers of anticoagulation therapy far outweigh the benefits, in my opinion [particularly for patients who] try to mix the use of anticoagulants with the MP.

Trevor Marshall, PhD

For these reasons, routine use of anticoagulants is contraindicated for Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP) patients. One possible exception is for patients who have a medical condition that requires the use of daily warfarin (Coumadin) to prevent embolism. Patients who have that condition consult their doctor about more frequent monitoring of your prothrombin time (INR) while on the MP to ensure that it remains at a safe level as inflammationThe complex biological response of vascular tissues to harmful stimuli such as pathogens or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. resolves.

N.B. warning against nimesulide avoid_drug_interactions

Ginko biloba may also act as an anti-coagulant

Types of anticoagulants

  • aspirin and other NSAIDs
  • heparin
  • warfarin (Coumadin)

===== Notes and comments =====

local deposition of fibrin that is initiated by the expression of tissue factor on activated macrophages and endothelial cells helps wall off the infected tissue and provides an important impediment to bloodstream invasion.

70 – Sepsis, Severe Sepsis, and Septic Shock ROBERT S. MUNFORD, ANTHONY F. SUFFRED

Mandell: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed. Copyright © 2009 Churchill Livingstone, An Imprint of Elsevier

===== References =====

Zappala C, Chandan S, George N, Faoagali J, Boots RJ. The antimicrobial effect of heparin on common respiratory pathogens. Crit Care Resusc. 2007 Jun;9(2):157-60.
[PMID: 17536984]
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