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Antiviral agents

By definition, antiviral agents are drugs used in the prophylaxis or therapy of virus diseases. However, the drugs have been used in a wide range of conditions from acute infections such as influenza to chronic inflammatory diseases such as chronic fatigue syndrome. Antivirals have profound effects on the immune system as well as a number of serious adverse effects. Routine use is generally contraindicated for Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP) patients. The decision to use antivirals is one which patients should make with their physicians in light of known side effects, contraindications and personal risk of effects from the flu.

Effect on the immune system

For many conditions, antiviral drugs alleviate symptoms of disease.1) However, this could be due to its effect on the immune response. Not enough is known about how exactly antivirals interact with the immune system, but certain preliminary indications strongly suggest that the drugs interfere with immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed.. This suggests that use of the drugs may delay recovery from chronic inflammatory disease.

The reported molecular actions of ganciclovir (Cytovene and Cymevene) may be telling.

During ganciclovir treatment of an adolescent ependymoma patient two weeks after intracranial implantation of HSVtk retroviral vector producer cells, increasing numbers of peripheral T- and B-cells were found as well as enhanced T-cell activation and elevated serum levels of interleukin 12 and soluble Fas ligand.

Kramm et al.2)

While antiviral drugs are supposed to treat only a virus, they appear to have profound effects on other immune functions in the human body. For this reason they are contraindicated for MP patients.

Adverse effects

Depending on the drug, antiviral drugs can have a number of side effects. Oseltamivir is somewhat typical. Common adverse drug reactions associated with oseltamivir therapy include: nausea, vomiting, diarrhea, abdominal pain, and headache as well as other neurological and psychiatric conditions.3)

Types of anti-viral treatments

  • acyclovir (Zovirax)
  • famciclovir (Famvir)
  • ganciclovir (Cytovene and Cymevene)
  • osletamivir (Tamiflu) – Drug that interferes with flu viral reproduction. In order for it to be effective, it must be taken within 40 hours of developing the flu.
  • valganciclovir (Valcyte)
  • valcyclovir HCL (Valtrex)
  • zanamivir (Relenza) – The drug is a powder that is inhaled twice a day for five days from a breath-activated plastic device. In order for the treatment to be most effective, patients need to start treatment within two days of the onset of symptoms.

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Notes and comments

A member of ours (SanDiegoJoy) originally “came down” with Sarcoidosis after anti-viral treatment for Hep-C. This is a note to self to look up any words in her posts that explains her experience.

References

1)
Valacyclovir treatment in Epstein-Barr virus subset chronic fatigue syndrome: thirty-six months follow-up.
Lerner AM, Beqaj SH, Deeter RG, Fitzgerald JT
In Vivo21p707-13(2007 Sep-Oct)
2)
Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient.
Kramm CM, Korholz D, Rainov NG, Niehues T, Fischer U, Steffens S, Frank S, Banning U, Horneff G, Schroten H, Burdach S
Neuropediatrics33p6-9(2002 Feb)
3)
Assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive review.
Toovey S, Rayner C, Prinssen E, Chu T, Donner B, Thakrar B, Dutkowski R, Hoffmann G, Breidenbach A, Lindemann L, Carey E, Boak L, Gieschke R, Sacks S, Solsky J, Small I, Reddy D
Drug Saf31p1097-114(2008)
home/othertreatments/antivirals.txt · Last modified: 01.03.2012 (external edit)
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