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Thyroid hormone supplementation

Due to the nature of chronic disease, it is common for patients suffering from chronic diseases to have low levels of the thyroid hormones. This may be due to high levels of the vitamin D metabolite 1,25-DPrimary biologically active vitamin D hormone. Activates the vitamin D nuclear receptor. Produced by hydroxylation of 25-D. Also known as 1,25-dihydroxycholecalciferol, 1,25-hydroxyvitamin D and calcitirol. which interferes with the production of hormones.

For patients who are taking a thyroid supplement, it is fine to continue that supplement while on the Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis.. The need for these supplements may change within a day or two of starting the olmesartan (Benicar)Medication taken regularly by patients on the Marshall Protocol for its ability to activate the Vitamin D Receptor.. Physicians will need to monitor thyroid function closely and adjust the level of thyroid supplementation downward as needed.

If a patient has a choice in thyroid supplements, it is recommended that patients take T3 instead of T4. This is due to the fact that T4 seems to affect the nuclear receptorsIntracellular receptor proteins that bind to hydrophobic signal molecules (such as steroid and thyroid hormones) or intracellular metabolites and are thus activated to bind to specific DNA sequences which affect transcription. in more profound ways than T3.

General advice about hormone supplementation

Due to the nature of chronic disease, it is common for patients suffering from chronic diseases to have low levels of hormones. This is often due to high levels of the vitamin D metabolite 1,25-DPrimary biologically active vitamin D hormone. Activates the vitamin D nuclear receptor. Produced by hydroxylation of 25-D. Also known as 1,25-dihydroxycholecalciferol, 1,25-hydroxyvitamin D and calcitirol. which interferes with the production of hormones such as T3, testosterone, etc. Because the vitamin D system is dysregulated in chronically ill patients, supplementing with other hormones tends to further dysregulate the receptors rather than increase hormonal expression. Thus, hormone supplementation is contraindicated. If the patient is already on hormone “replacement” therapy, judicious use of low-dose hormone therapy (to relieve intolerable symptoms) may be necessary until the patient is able to wean from the hormones.

Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP) patients are advised to work with their doctor to use the lowest dose of medication that is effective.

As patients begin to kill the Th1 pathogensThe community of bacterial pathogens which cause chronic inflammatory disease - one which almost certainly includes multiple species and bacterial forms. causing their disease, vitamin D metabolism restabilizes and 1,25-D's effects on hormonal stabilization becomes less of an issue. Once this happens, there is no longer a need to take extra hormone supplements, and patients can then wean off their steroids.

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Types of thyroid hormones

  • T3 – liothyronine sodium (Cytomel, L-Triiodothyronine, Tertroxin, Triostat)
  • T4 – levothyroxine (Eltroxin, Euthyrox, Levothroid, Levoxyl, L-Thyroxine, Synthroid, Unithroid)
  • Armour Thyroid – whole thyroid preparation consisting of T4 (thyroxine) and T3 (triiodothyronine) in the proportions usually present in pig thyroids (approximately 80% T4 and 20% T3); made in the following strengths: 1/8, 1/4, 1/2, 1, 2, and 3 grain as well as 4 and 5 grain tablets.

T3 vs. T4 supplements

Between T3 and T4 supplements, T4 seems to have a particularly strong effect on the nuclear receptors. According to in silicoExperiment technique performed on computer or via computer emulation. modeling:

T4 has a 10 times higher affinity for the PPAR-alpha receptor [than T3], a 35 times higher for the Glucocorticoid Receptor, and twice as strong into the PPAR-gamma receptor.

Trevor Marshall, PhD

For this reason, it is recommended that patients take T3 instead of T4.

Taking thyroid supplements while on the Marshall Protocol

For patients who are taking a thyroid supplement, it is fine to continue that supplement while on the Marshall Protocol. However, as with other hormonal supplements, there are serious concerns that supplemented thyroid hormones interfere with the proper functioning of the nuclear receptors including PPAR-alpha, PPAR-gamma, and the Glucocorticoid Receptor. Patients should not stop or alter their thyroid supplementation without consulting their doctor.

Need for thyroid supplements changes throughout the MP

Patients who are taking thyroid supplements should be aware that their need for those supplements may change within a day or two of starting olmesartan (Benicar). This is due to olmesartanMedication taken regularly by patients on the Marshall Protocol for its ability to activate the Vitamin D Receptor. Also known by the trade name Benicar. 's ability to rapidly reduce 1,25-D. 1,25-D is often high in patients with Th1 DiseasesThe chronic inflammatory diseases caused by bacterial pathogens. and, at those levels, interferes with the production of thyroid hormones.

Patients have also noticed that their need for thyroid medication drops as they progress along on the Marshall Protocol. For this reason, physicians may need to monitor their patients' thyroid function more closely than they otherwise would. Any of the following signs of hyperthyroidism may imply the need to wean thyroid medication:

  • palpitations
  • heat intolerance
  • nervousness
  • breathlessness
  • increased bowel movements
  • light or absent menstrual periods
  • fatigue
  • fast heart rate
  • trembling hands
  • weight loss
  • muscle weakness
  • warm moist skin
  • hair loss
  • staring gaze

The decision to wean thyroid hormones should always be made in conjunction with a doctor and with an eye towards lab results. Bear in mind that it may take about six weeks before one sees the adjustment of T4 supplementation, for example, in one's blood work.

Immunopathology or thyroid imbalance

Given that immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed. will provoke bouts of severe fatigue, patients should not be tempted to use additional thyroid medication. Increased fatigue is often, if not always, due to increased bacterial die-off. Fatigue will resolve as a patient's bacterial load is eradicated.

Patients experiences

I was hypothyroid and took T3 & T4 before starting the MP lifestyle late September. My thyroid already began to alter with the avoidance of sun and other sources of vitamin D. By the time I started with Benicar in November, I was hyperthyroid and had to stop supplementing. By December, my thyroid was tested in the normal range! The need for thyroid medications can change pretty quickly on the MP, as the hormones begin to shift - which is why you should check it often.

Alayne

I had hypothyroidism pre-MP and took medications, and now I don't need any…. The test results speaks volumes.

Sharon

I got an email from my doctor today. My 25-DThe vitamin D metabolite widely (and erroneously) considered best indicator of vitamin D "deficiency." Inactivates the Vitamin D Nuclear Receptor. Produced by hydroxylation of vitamin D3 in the liver. level is down to 11 and my TSH is way low. He told me to stop my Cytomel immediately. I am having minimal symptoms and my hot flashes have completely vanished within the last week or so.

Ctaegar

When I became jittery, anxious, restless, or teary-eyed, I soon came to realize that my physician needed to adjust my thyroid medication. Thus, please understand that your body is experiencing great hormonal changes as you progress on the protocol, so the new or repeated symptoms are to be expected.

Carole

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References

home/othertreatments/thyroid_hormones.txt · Last modified: 10.25.2018 by sallieq
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