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Welcome to the MPKB

The Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. or MP is a therapy for chronic inflammatory diseases devised by Trevor Marshall, PhD. The MP is based on an explanation for how an infectious cascade of pathogens slow the immune response and allow for subsequent infections to proliferate, thereby causing the symptoms and markers of disease.

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For Patients

Why microbes may cause chronic inflammatory diseases
- Introduction to the Marshall Pathogenesis
- Successive infection and variability in disease
- Transmission of bacteria and onset of disease
- Microbes in the human body
- Diseases – articles about microbes' role in a given chronic disease; note: many are works in progress
- The available evidence
What is the Marshall Protocol? – The cornerstone of the MP is frequent dosing of olmesartanMedication taken regularly by patients on the Marshall Protocol for its ability to activate the Vitamin D Receptor. Also known by the trade name Benicar. (brand name Benicar), which stimulates the innate immune responseThe body's first line of defense against intracellular and other pathogens. According to the Marshall Pathogenesis the innate immune system becomes disabled as patients develop chronic disease..
- Introduction
- Length – may take several years depending on how sick a patient is
- Cost – insurance often pays for certain basic expenses; drugs can be ordered online at a discount
- Palliative vs. curative treatments – many widely used treatments and supplements such as vitamin D compromise the immune response to microbes and are therefore contraindicated
Considering the Marshall Protocol
- Therapeutic probe – best method for determining suitability of the Protocol
- Vitamin D Metabolite Calculator – get automated feedback on vitamin D blood tests
- Patient interviews
Starting the treatment – Overview | Checklist
Physicians – Finding a physician | Working with a physician
The Protocol – In-depth overview of the Protocol | Translations of this and other articles
- Immunopathology – temporary increase in disease symptoms experienced by MP patients that is the result of microbial death; appears to be necessary for recovery
- Managing immunopathology – certain strategies are helpful including lowering antibiotics and adjusting olmesartan
- Light restriction – patients who are photosensitiveAbnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare." on the MP become less symptomatic when they limit skin exposure to light when outdoors, and skin and eye exposure when indoors
- Food & drink – patients limit vitamin D
- Other treatments – patients only take other medications that offer needed relief from intolerable symptoms
Learn more
- Site map contains a list of all articles in the KB
- Glossary of terms

For Physicians

Resources for physicians
The Marshall Pathogenesis
About immunopathology a.k.a. the Jarisch-Herxheimer reaction
Safety of the Protocol – olmesartan (Benicar), antibiotics
Summary of MP, Guidelines
Physicians' concerns
Notice for emergency

News and highlights

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Publications/presentations

Immunostimulation in the era of the human metagenome - paper in Molecular and clinical immunology that reviews a case series of Marshall Protocol patients and discusses how immunostimulatory approaches may require rethinking medicine

Autoimmune disease and the human metagenome - book chapter in Springer's Metagenomics of the human body that discusses how the process of successive infection may be responsible for autoimmune disease

Olmesartan overcomes antibiotic resistance, inducing recovery from advanced autoimmune disease – presentation by Trevor Marshall, PhD at International Congress on Autoimmunity

Olmesartan medoxomil and treatment of autoimmune disease – presentation by Greg Blaney, MD

→ Complete list

About the MPKB Project

The MPKB currently contains about 400 pages and draws from the best possible evidence to support its mission. As of May 2011, about 85% of those articles are complete with the remainder scheduled to be completed.

About Autoimmunity Research Foundation

Autoimmunity Research Foundation is a California-based 501©3 (tax deductible) non-profit formed to educate the public about the nature of, and study a treatment for, chronic inflammatory disease.

History and timeline of the Autoimmunity Research Foundation

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