Related articles: Mistaking correlation for causation in vitamin D studies, Incidence and prevalence of chronic disease
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Related articles: Mistaking correlation for causation in vitamin D studies, Incidence and prevalence of chronic disease
According to the Marshall PathogenesisA description for how chronic inflammatory diseases originate and develop., chronic inflammatory disease is caused by a microbiotaThe bacterial community which causes chronic diseases - one which almost certainly includes multiple species and bacterial forms. of pathogens which interfere with proper functioning of the innate immune system. Patients suffering from inflammatory diseases have been shown to have lower than normal levels of 25-hydroxyvitamin D, and there are at least several reasons why bacterial pathogens generate this response.
A full understanding of vitamin D metabolism supports the conclusion that elevated 1,25-D and depressed 25-D are a result rather than a cause of the inflammatory process.
Lower than normal levels of 25-D have been independently associated both with all-cause mortality1) 2) and a number of chronic inflammatory diseases. The following selection of diseases (and patient groups) have been observed to display the hallmarks of this kind of dysregulated vitamin D metabolism.
TECHEDIT
Here's another study that is consistent with the new science of vitamin D: http://www.sciencedaily.com/releases/2010/12/101208083047.htm
A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that lower AND higher vitamin D levels were associated with an increased likelihood of frailty in older women. Women with vitamin D levels between 20.0 and 29.9 ng/ml were at the lowest risk of frailty.
This new study however found a U-SHAPED RELATIOSHIP between vitamin D levels and frailty; older women with vitamin D levels higher than 30 ng/ml and those with levels lower than 20 ng/ml were more likely to be frail.
“Vitamin D supplementation has grown in popularity, yet the association between vitamin D status and risk of adverse health outcomes in older adults is uncertain,“ said Kristine Ensrud, MD, professor of medicine and epidemiology, Minneapolis VA Medical Center and the University of Minnesota and lead author of the study. “Our study did not find that higher vitamin D status was associated with lower subsequent risks of frailty or death. In fact, higher levels of vitamin D were associated with increased likelihood of frailty.”
“Evidence is lacking to support use of vitamin D supplementation for prevention of frailty and other outcomes including cancer or all-cause mortality,” said Ensrud.